Do you offer models with specific genetic mutations?

Yes, we have a collection of models with common fAD mutations (e.g., APP London, Swedish; PSEN1 ΔE9) and can develop custom lines with specific mutations using gene-editing technologies like CRISPR/Cas9.

What is the advantage of using 3D models over 2D cultures for AD research?

3D models (organoids/spheroids) better mimic the in vivo brain microenvironment, facilitating more complex cell-cell interactions, nutrient/waste gradients, and often more robust recapitulation of AD pathologies like Aβ aggregation and tauopathy development.

Do you provide differentiated cells or progenitor cells?

We can provide both, depending on your needs – from pluripotent stem cells and neural progenitor cells to fully differentiated mature neural cell types.

Do you offer models for other neurodegenerative diseases?

Yes, Creative Biolabs has a growing portfolio of cell models for various neurodegenerative conditions, including Parkinson's disease, ALS, and Huntington's disease.

How can I get a quote for a specific AD cell model or a custom project?

Please visit our website or contact our technical sales team directly through the inquiry form. We'll be happy to discuss your requirements and provide a detailed quotation.

Online Inquiry

Alzheimer's Disease (AD) Cell Model Products

Introduction Features Advantages Applications FAQs Related Product Sections Product List

Introduction

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Its complex pathology, involving amyloid-β (Aβ) plaques and neurofibrillary tangles of tau protein, necessitates robust and physiologically relevant research models. Traditional immortalized cell lines like PC12, while useful for initial studies, are often of rodent origin and may not fully recapitulate human AD. Recent advancements, particularly with human induced pluripotent stem cells (iPSCs) and 3D culture systems, have revolutionized AD modeling by allowing the generation of patient-specific human neurons that can develop key disease hallmarks in vitro, offering invaluable tools for mechanistic studies and drug discovery. Contact our expert team to discuss how we can support your specific research objectives and accelerate your path to discovery; we also invite you to explore our innovative solutions.

Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.

Features of Our Alzheimer's Disease Cell Models

Creative Biolabs offers a diverse portfolio of AD cell models, engineered and characterized to meet the rigorous demands of neurodegenerative disease research:

Features	Description
Human-Derived Systems	Primarily utilizing induced pluripotent stem cells (iPSCs) from both healthy donors and AD patients (familial and sporadic forms), ensuring high biological relevance.
Patient-Specific Lines	Access models carrying specific familial AD mutations (e.g., in APP, PSEN1, PSEN2) or risk factor variants (e.g., APOE4), as well as lines from sporadic AD patients.
Diverse Neural Cell Types	Including cortical neurons (glutamatergic and GABAergic), astrocytes, microglia, and oligodendrocytes, available as monocultures or complex co-culture systems.
Advanced 2D & 3D Cultures	2D Monolayers: For high-throughput screening, biochemical assays, and electrophysiological studies. 3D Brain Organoids & Spheroids: Offering enhanced physiological relevance, complex cell-cell interactions, and a microenvironment more conducive to recapitulating AD pathologies like amyloid-beta (Aβ) aggregation and tau hyperphosphorylation.
Pathology-Relevant Characterization	Custom generation of cell lines using CRISPR/Cas9 technology to introduce or correct specific mutations, or to insert reporter genes.
Ready-to-Use & Custom Development	Choose from our catalog of established AD cell models or collaborate with our scientists to develop a custom model tailored to your specific research questions.
Comprehensive Data Package	Models are supplied with detailed characterization data, including genetic verification, marker expression, and pathological readouts where applicable.

Advantages of Partnering with Creative Biolabs for AD Cell Models

Leveraging our AD cell models can significantly enhance your research capabilities:

Unravel Human-Specific Disease Mechanisms

Study AD in a human genetic context, moving beyond the limitations of animal models that often fail to fully mirror human pathology.

Accelerate Drug Discovery & Development

Utilize robust, reproducible human cell-based assays for target identification, validation, and preclinical efficacy and toxicity screening of novel therapeutic candidates.

Investigate Early & Late Pathological Events

Our models, including those derived from early-onset familial AD and Down syndrome iPSCs, can recapitulate different stages of disease progression.

Model Complex Cellular Interactions

Employ 3D organoids and co-culture systems to study the interplay between different neural cell types (neurons, astrocytes, microglia) in AD pathogenesis and neuroinflammation.

Reduce Reliance on Animal Testing

Contribute to the 3Rs (Replacement, Reduction, Refinement) by using advanced in vitro human models.

Access Specialized Expertise

Benefit from our team's deep knowledge in stem cell biology, neuronal differentiation, 3D culture technology, and neurodegenerative disease modeling.

Flexible & Customizable Solutions

We work closely with you to provide models that precisely fit your experimental needs, from off-the-shelf lines to fully bespoke development projects.

Applications of Overexpression Neural Model Cell Products

Our overexpression neural cell models are versatile tools for diverse neuroscience applications, enabling in-depth research across various areas:

Applications	Description
Disease Mechanism Studies	Investigate AD's fundamental molecular pathways, including APP processing, Aβ and tau pathologies, synaptic dysfunction, and neuronal death. Explore the roles of specific genes, risk factors, and cellular interactions in disease initiation and progression, including early pathogenic events.
Drug Discovery and Development	Enable high-throughput screening for novel compounds, target identification/validation, and preclinical assessment of drug efficacy (modulating Aβ, tau, neuroinflammation, or neuronal survival) and toxicity in human-relevant neural cells.
Biomarker Discovery	Identify and validate novel soluble or cell-associated biomarkers for AD pathology or therapeutic response within a human cellular context.
Neuroinflammation Research	Utilize iPSC-derived microglia, astrocytes, or co-culture models to study neuroinflammatory responses in AD and screen for anti-inflammatory agents.
Modeling Neurodevelopmental Aspects	Study how conditions like Down syndrome contribute to early AD pathology.
Basic Neuroscience Research:	Explore fundamental human neuronal development, function, and degeneration using our characterized neural cell types.

A picture that presents the three primary pathophysiological manifestations of Alzheimer's disease. (Madnani, et al., 2023) (OA Literature)

Fig.1 Graphical representation of the three primary pathophysiological manifestations of Alzheimer's disease.¹

FAQs

Do you offer models with specific genetic mutations?
Yes, we have a collection of models with common fAD mutations (e.g., APP London, Swedish; PSEN1 ΔE9) and can develop custom lines with specific mutations using gene-editing technologies like CRISPR/Cas9.
What is the advantage of using 3D models over 2D cultures for AD research?
3D models (organoids/spheroids) better mimic the in vivo brain microenvironment, facilitating more complex cell-cell interactions, nutrient/waste gradients, and often more robust recapitulation of AD pathologies like Aβ aggregation and tauopathy development.
Do you provide differentiated cells or progenitor cells?
We can provide both, depending on your needs – from pluripotent stem cells and neural progenitor cells to fully differentiated mature neural cell types.
Do you offer models for other neurodegenerative diseases?
Yes, Creative Biolabs has a growing portfolio of cell models for various neurodegenerative conditions, including Parkinson's disease, ALS, and Huntington's disease.
How can I get a quote for a specific AD cell model or a custom project?
Please visit our website or contact our technical sales team directly through the inquiry form. We'll be happy to discuss your requirements and provide a detailed quotation.

Creative Biolabs provides specialized Alzheimer's Disease (AD) cellular models. Our repertoire, spanning patient-derived iPSCs and complex 3D brain organoids to meticulously engineered cell lines, offers physiologically relevant platforms crucial for research. These systems are instrumental for dissecting AD pathomechanisms, identifying novel therapeutic targets, and thereby accelerating the development of innovative treatment paradigms. We integrate cutting-edge science with exhaustive characterization, ensuring our models generate robust, actionable data. Contact us to discuss how these AD cell models can propel their specific research objectives.