Can you develop a cell model expressing a novel or mutated antigen?

Yes. Our custom services are a core part of our offering. We can develop a stable cell line for virtually any neuronal antigen, including newly discovered targets or specific variants associated with disease. We encourage you to contact our team to discuss the specifics of your project.

What do I need to know before using your models for a cell-based assay?

Our models are optimized for robust and reproducible performance. We provide detailed protocols covering recommended growth conditions, media, and passage numbers. For cell-based assays, it's important to consider the specific endpoint, as this may guide the selection of the host cell line and assay format. Our technical support team is available to help you with assay design.

How do I know which model is right for my research?

The best model depends on your specific research question. If you are studying NMDAR antibodies, an NMDAR-expressing line is ideal. If you are investigating the T-cell/B-cell interaction, a co-culture system may be more appropriate. We welcome you to schedule a consultation with our scientific experts to discuss your project and ensure you select the perfect model for your needs.

How do you ensure the purity of the cell populations?

We use advanced techniques, including fluorescence-activated cell sorting (FACS) with a panel of validated antibodies to achieve high purity, which is confirmed by post-sort flow cytometry analysis.

Do you offer cells from different lymphoid organs?

Yes. We can provide cells isolated from various tissues, including the spleen, brain, and the critical brain-draining cervical lymph nodes (cLN), where the autoimmune response is known to mature.

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Autoimmune Encephalitis Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Autoimmune Encephalitis (AE) represents a group of severe, immune-mediated inflammatory disorders of the brain's parenchyma. While our understanding of the neuronal autoantibodies involved has grown, a significant gap persists between laboratory discoveries and clinical reality. Researchers like you understand the core challenges: the diagnostic journey is complex, animal models can be unpredictable, and the presence of autoantibodies alone is often a poor biomarker for disease onset or severity. It's clear that to develop next-generation diagnostics and therapeutics, we must look deeper at the cellular level.

At Creative Biolabs, we empower you to bypass the hurdles of model development and focus directly on your research goals. Our portfolio of highly characterized, ready-to-use Autoimmune Encephalitis Cell Models provides the critical tools you need to dissect the complex cellular interplay at the heart of AE. Contact our team of Ph.D.-level specialists for expert guidance in selecting the optimal model that meets your project's unique requirements.

Alternatively, specific offerings can be found by directly consulting our Product List.

Types

We offer a focused selection of cell models critical for studying AE and related neuroinflammatory conditions.

Types	Description
Antigen-Specific B Cells	Isolate the key players. We provide B cells specific for crucial autoantigens like MOG, NMDAR, LGI1, and CASPR2, enabling you to study the cells driving the humoral response directly.
T Cell Populations	Including CD4+ T cells from relevant disease models, essential for studying the T-cell/B-cell cooperation that triggers and sustains autoimmunity.
Plasmablasts & Plasma Cells	Study the antibody-secreting effector cells, characterized by markers like CD138, to investigate terminal differentiation and antibody production.
Co-culture Systems	Advance your research with ready-to-use systems that model the interaction between different immune cell subsets (e.g., B cells and T cells).
Validated Control Cells	We provide corresponding control cells from healthy, non-transgenic littermates (NTL) to ensure you have the proper experimental baselines.

Advantages

Choosing our cell models isn't just a purchase; it's an investment in efficiency, reliability, and scientific depth.

Accelerate Your Research Timelines:

Eliminate the time, cost, and unpredictability associated with developing and validating cell lines or maintaining complex animal colonies from scratch.

Achieve Unmatched Reproducibility:

Start your experiments with a consistent, well-defined cell population, reducing variability and strengthening the validity of your conclusions.

Elucidate Complex Cellular Pathways

Our models provide a powerful in vitro system to interrogate specific interactions, such as the critical role of B cells in presenting antigens to T cells or the maturation of the autoimmune response in brain-draining cervical lymph nodes.

Reduce & Refine Animal Use

Perform initial screening and mechanistic studies in a controlled in vitro setting, aligning with the 3Rs principles (Replacement, Reduction, Refinement) and focusing in vivo studies on the most promising candidates.

Primary Applications

Our AE cell models are versatile tools designed to support a wide range of cutting-edge research applications:

Applications	Description
Therapeutic Agent Screening	Efficiently screen small molecules, biologics, or cell-based therapies for their ability to modulate pathogenic immune responses.
Mechanism of Action (MoA) Studies	Investigate the specific cellular and molecular pathways driving AE, from B-cell activation and clonal expansion to cytokine production.
Biomarker Discovery	Address the challenge that MOG-antibodies are poor biomarkers of disease onset by using our models to identify novel, more reliable cellular or soluble markers of pathogenic activity.
Pathophysiology Research	Model the specific cell-cell interactions that lead to neuroinflammation, such as the cross-talk between follicular helper T cells and antigen-specific B cells in germinal center-like reactions.

A picture that presents the autoimmune encephalitis mechanisms. (Patel, et al., 2021) (OA Literature)

Fig.1 Mechanisms of autoimmune encephalitis.¹

FAQs

Can you develop a cell model expressing a novel or mutated antigen?
Yes. Our custom services are a core part of our offering. We can develop a stable cell line for virtually any neuronal antigen, including newly discovered targets or specific variants associated with disease. We encourage you to contact our team to discuss the specifics of your project.
What do I need to know before using your models for a cell-based assay?
Our models are optimized for robust and reproducible performance. We provide detailed protocols covering recommended growth conditions, media, and passage numbers. For cell-based assays, it's important to consider the specific endpoint, as this may guide the selection of the host cell line and assay format. Our technical support team is available to help you with assay design.
How do I know which model is right for my research?
The best model depends on your specific research question. If you are studying NMDAR antibodies, an NMDAR-expressing line is ideal. If you are investigating the T-cell/B-cell interaction, a co-culture system may be more appropriate. We welcome you to schedule a consultation with our scientific experts to discuss your project and ensure you select the perfect model for your needs.
How do you ensure the purity of the cell populations?
We use advanced techniques, including fluorescence-activated cell sorting (FACS) with a panel of validated antibodies to achieve high purity, which is confirmed by post-sort flow cytometry analysis.
Do you offer cells from different lymphoid organs?
Yes. We can provide cells isolated from various tissues, including the spleen, brain, and the critical brain-draining cervical lymph nodes (cLN), where the autoimmune response is known to mature.

The complexity of Autoimmune Encephalitis demands more sophisticated tools. Move beyond the limitations of traditional methods and gain a deeper understanding of the cellular drivers of disease. The team at Creative Biolabs is ready to provide the robust, highly validated cell models you need to power your next discovery. Connect with our experts to discuss your project needs and receive a personalized quote.