What exactly are your Paraneoplastic Neurologic Syndrome (PNS) cell models?

Our PNS models are highly specialized human cells, primarily neurons and glial cells, that are developed from induced Pluripotent Stem Cells (iPSCs). They are engineered to create a biologically relevant in vitro system that mimics the human nervous system, providing a powerful platform for studying the complex mechanisms of PNS.

Why should I use your iPSC-derived models instead of traditional animal models?

While animal models have their uses, they often fail to accurately replicate the human-specific aspects of autoimmune diseases like PNS. Our human iPSC-derived models provide superior physiological relevance, leading to more predictive and translatable data that can better inform clinical outcomes and accelerate your research.

Can I use these cells for high-throughput screening (HTS)?

Yes, absolutely. Our iPSC-derived models are an excellent platform for HTS. Due to their high purity, exceptional lot-to-lot consistency, and scalability, they can be readily automated in 96-well or 384-well formats, making them ideal for large-scale drug discovery and compound screening campaigns.

Can you create a cell model from a specific patient line or with a specific genetic modification?

Yes. A core part of our service is custom model development. Our scientific team can partner with you to generate iPSC lines and differentiated neural models from patient samples or introduce specific genetic modifications. This provides a powerful tool for personalized medicine research and for investigating the role of specific genes in PNS.

What kind of technical support do you offer?

We are committed to your success. Every purchase is backed by our team of PhD-level scientists who are available to provide comprehensive technical support. We can assist with everything from initial experimental design and protocol optimization to data interpretation and troubleshooting, ensuring you get the most value from our models.

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Paraneoplastic Neurologic Syndrome Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Paraneoplastic Neurologic Syndromes (PNS) are devastating disorders where an anti-tumor immune response cross-reacts with the nervous system. Progress is hindered by complex disease mechanisms and a scarcity of biologically relevant human models, creating significant bottlenecks in developing effective diagnostics and therapies.

At Creative Biolabs, we empower you to overcome these hurdles. Leveraging two decades of expertise, we have developed a comprehensive portfolio of human iPSC-derived neural models for PNS research. Our models provide a crucial window into disease pathophysiology, accelerating your path to discovering novel treatments and giving new hope to patients.

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Types

At Creative Biolabs, we offer a diverse range of validated cell models and services. Find the precise tools your research requires from our specialized catalog.

Types	Description
PNS Neuronal Models	These are cell lines expressing antigens such as HuD or Ri. Perfect for investigating neuron-specific pathophysiology, like antibody-induced apoptosis or synaptic changes.
High-Expression Screening Models	Stable HEK293 lines providing high-yield onconeural antigens (e.g., Yo, CRMP5). Engineered for robust, reproducible use in diagnostic development and high-throughput antibody screening.
Human iPSC-Derived Models	Custom-generated neurons or astrocytes from patient or control iPSCs. Provides the ultimate human-relevant system for studying disease mechanisms and testing next-generation therapeutics.
Reporter Gene Cell Lines	Models engineered with fluorescent (e.g., GFP) or luminescent reporters. Enables real-time tracking of protein expression, antibody internalization, or downstream signaling pathway activation.
Custom Model Development Service	Our expert team will create a bespoke model with your specific antigen, mutation, or reporter tag in any desired cellular background to meet your unique needs.

Advantages

Partnering with Creative Biolabs provides a distinct competitive edge. We empower your research with key advantages designed to maximize your return on investment and accelerate your scientific mission.

Accelerate Research Timelines

Move from target validation to lead optimization in a fraction of the time. Our ready-to-use models eliminate setup delays, delivering actionable data significantly faster.

Reduce Costly Late-Stage Failures

Identify non-viable drug candidates or off-target effects early. Make confident go/no-go decisions, saving millions in potential preclinical and clinical costs.

Enhance Decision-Making Confidence

Replace ambiguous results with clear, mechanistic insights. Our highly validated models provide the reproducible data needed to make decisive project commitments with minimal risk.

Strengthen Regulatory Submissions

Build a more compelling data package for IND filings. Our models use authenticated human cell lines, providing the physiologically relevant data that regulatory agencies value.

Ensure Unmatched Reproducibility

Eliminate the variability of other systems. Our stringently quality-controlled models ensure exceptional batch-to-batch consistency, providing reliable data for long-term research programs.

Gain an Expert Scientific Partner

Access our PhD-level support team. We help you select the right models, design effective experiments, and interpret complex data, ensuring your project's success.

Applications

From foundational discovery to preclinical validation, Creative Biolabs models are engineered to provide actionable data across a wide spectrum of research applications.

Applications	Description
Autoantibody Screening & Detection	Reliably screen patient serum and CSF for known or novel onconeural autoantibodies. Our models provide the sensitivity needed for accurate patient stratification and cohort discovery.
Diagnostic Kit & Assay Development	Utilize our models as a renewable, validated antigen source to build next-generation diagnostic kits, including cell-based assays (CBAs), ELISAs, and immunofluorescence assays (IFAs).
Unraveling Disease Mechanisms	Dissect the molecular pathways of neuronal injury following antibody binding. Analyze downstream events like calcium dysregulation, mitochondrial stress, and apoptotic signaling for mechanistic clarity.
Antibody Internalization & Trafficking	Visualize the real-time binding and internalization of pathogenic antibodies using our neuronal models, providing direct visual evidence of a primary pathogenic mechanism in living cells.
Modeling Immune Cell Cytotoxicity	Establish co-culture systems with our models to investigate T-cell-mediated cytotoxicity or microglial activation, recreating the neuroinflammatory microenvironment of PNS in a dish.
High-Throughput Therapeutic Screening	Screen compound or biologic libraries to identify agents that block antibody binding, inhibit downstream toxicity, or promote neuronal survival in a robust and scalable format.
Neuroprotective Agent Validation	Assess the efficacy of neuroprotective compounds in preventing neuronal damage. Use patient antibodies to induce injury and precisely quantify your candidate drug's rescue effect.

A picture that presents the proposed pathophysiologic mechanism. (Chiu, et al., 2023) (OA Literature)

Fig.1 Proposed pathophysiologic mechanism of paraneoplastic neurologic disorders.¹

FAQs

What exactly are your Paraneoplastic Neurologic Syndrome (PNS) cell models?
Our PNS models are highly specialized human cells, primarily neurons and glial cells, that are developed from induced Pluripotent Stem Cells (iPSCs). They are engineered to create a biologically relevant in vitro system that mimics the human nervous system, providing a powerful platform for studying the complex mechanisms of PNS.
Why should I use your iPSC-derived models instead of traditional animal models?
While animal models have their uses, they often fail to accurately replicate the human-specific aspects of autoimmune diseases like PNS. Our human iPSC-derived models provide superior physiological relevance, leading to more predictive and translatable data that can better inform clinical outcomes and accelerate your research.
Can I use these cells for high-throughput screening (HTS)?
Yes, absolutely. Our iPSC-derived models are an excellent platform for HTS. Due to their high purity, exceptional lot-to-lot consistency, and scalability, they can be readily automated in 96-well or 384-well formats, making them ideal for large-scale drug discovery and compound screening campaigns.
Can you create a cell model from a specific patient line or with a specific genetic modification?
Yes. A core part of our service is custom model development. Our scientific team can partner with you to generate iPSC lines and differentiated neural models from patient samples or introduce specific genetic modifications. This provides a powerful tool for personalized medicine research and for investigating the role of specific genes in PNS.
What kind of technical support do you offer?
We are committed to your success. Every purchase is backed by our team of PhD-level scientists who are available to provide comprehensive technical support. We can assist with everything from initial experimental design and protocol optimization to data interpretation and troubleshooting, ensuring you get the most value from our models.

Don't let model limitations impede your next discovery. By integrating Creative Biolabs' high-fidelity PNS cell models into your research, you gain a reliable, relevant, and scalable platform to investigate disease mechanisms and screen for next-generation therapeutics. Our team of expert scientists is ready to understand your unique challenges and recommend the best solution for your project. Contact us today to request a detailed quote, discuss a custom model development project, or schedule a technical consultation with our R&D specialists.