Basic Neuroscience Research Tools

Overview Service Features Applications FAQs Scientific Resources Related Services

Brain is the most complex organ in humans and has been served as the origin of emotions, thoughts, and behaviors. To better understand the connection and function between neurons and glia, Creative Biolabs has developed a series of basic neuroscience research tools for our clients all over the world.

Overview of Basic Neuroscience Tools

Basic neuroscience tools encompass a variety of techniques and technologies that are essential for studying the brain and nervous system. These tools play a crucial role in advancing our understanding of brain function and dysfunction, and are used in a wide range of research areas including neurology, psychiatry, and neurobiology.

Electrophysiology: Electrophysiological techniques are used to study the electrical activity of neurons and neuronal circuits in the brain. These techniques include patch-clamp recording, field potential recording, and multielectrode array recording, which allow researchers to measure and manipulate the electrical signals generated by neurons.
Neuroimaging: Neuroimaging techniques, such as magnetic resonance imaging (MRI), positron emission tomography (PET), and functional MRI (fMRI), provide valuable information about the structure and function of the brain in both healthy and diseased states. These tools are essential for studying brain anatomy, connectivity, and activity in vivo.
Optogenetics: Optogenetics is a powerful technique that combines genetic engineering and light stimulation to control the activity of specific neurons in the brain. By using light-sensitive proteins called opsins, researchers can selectively activate or inhibit neurons with high spatial and temporal precision, allowing for the study of neuronal circuits and behavior.
Genetic engineering tools: Advances in genetic engineering, such as CRISPR-Cas9 technology, have revolutionized the field of neuroscience by enabling researchers to manipulate the genetic makeup of animals and cells with unprecedented precision. These tools are used to create animal models of neurologic and psychiatric disorders, as well as to study the role of specific genes in brain function.

Basic neuroscience tools are essential for advancing our understanding of the brain and nervous system, and are critical for developing new therapies and treatments for neurological and psychiatric disorders. We play a key role in developing and commercializing these tools, driving innovation in neuroscience research.

Service Features

Below is an overview of some of the neuroscience tools we offer.

Viral Vector for Neural Circuitry Research

Viral vectors are genetically modified vectors generated via genetic engineering. To avoid potential safety issues, the pathogenic genes in the virus are completely or mostly eliminated. Its high safety, higher precision, and more specific characteristics make it widely used in neuroscience, metabolism, oncology, and other multidisciplinary research fields.

Neuronal Marker Antibody

Neuronal markers are a class of proteins that can be used to identify specific neuronal subgroups. In this case, the neuron marker antibody we developed has been used as a powerful tool for a variety of studies, such as distinguishing cell types in the nervous system, evaluating cell or protein co-localization, visualization of synaptic connections, and cell health assessment.

Neuroactive Peptide

Neuroactive peptides refer to endogenous protein molecules that are comprised of at least two amino acids. Till now, there are almost 100 different neuroactive peptides have been identified. Exist in nearly all areas of the neuron, neuroactive peptides stimulate a range of diverse biological activities. Now Creative Biolabs provides custom production of neuroactive peptides.

Neuromodulating Compounds

Neuromodulating compounds, also known as neuromodulators, refer to chemical messengers released from neurons in the CNS or PNS. By controlling the number of neurotransmitters synthesized and released by neurons, neuromodulating compounds can change neuronal signal transmission. In summary, neuromodulating compounds modify neuronal dynamics, excitability, and synaptic function.

Reprogramming Factors

Reprogramming is the process that iPSCs are generated from differentiated mature cells. The reprogramming factors spontaneously bind together to form an interconnected autoregulatory circuitry, triggering their core promoter genes and cooperating with other pluripotency-associated genes.

Direct Conversion Factors

The process of direct conversion refers to the direct transformation of nerve cells from one cell lineage to other cell types through the expression of specific conversion factors. There are a series of conversion factors, including Pax6, Ascl1, Ngn2, and Dlx2.

Optogenetic Actuators

Optogenetics commonly refers to genetically encoded light-activated channels that enable analysis and modification of neural activity. Optogenetic actuators are light-driven proteins to perturb electrochemical signals, as well as induce many action potentials, or modify signaling pathways.

Optogenetic Indicators

Optogenetics is a new genetic tool used to control the activity of specific neurons in complete neuronal circuits. Compared with conventional neuromodulatory approaches, the advantage of optogenetics is its compatibility with genetics. Optogenetics has been used for the treatment of neurological disorders, such as PD, AD, and epilepsy.

Fluorescent Sensor

The fluorescence sensor has become one of the most widely used sensor types due to its high sensitivity. In neuroscience, the most used fluorescent sensors are genetically encoded calcium indicators (GECI), genetically encoded voltage indicators (GEVI), and pH sensors.

Immortalized Cell Lines

Immortality is established when a cell loses its cell cycle checkpoint pathway, and telomerase activity is a key factor in establishing immortality. Immortalized neural cell lines provide novel and important insights into the basic principles of developmental neurobiology.

Primary Cell Lines

Culturing nerve cells in vitro has played an important role in understanding the basic physiological processes of nervous system cells. Examples of primary cell lines application in neuroscience include cerebellar granule cells, cholinergic neurons, and striatal neurons.

Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms for a broad range of neurosciences research, now we provide a series of custom neuroscience research tools for our clients all over the world. We are pleased to use our extensive experience to offer the best service and the most qualified products to satisfy each demand from our customers.

Applications of Basic Neuroscience Tools

Some of the key applications of our basic neuroscience tools include:

To study the electrical activity of neurons and other cells in the brain
To manipulate the activity of specific neurons
To study genetic and molecular mechanisms underlying neurological diseases and disorders
To visualize and study the structure and function of neural circuits, synapses, and other cellular components in the brain
To investigate the pathophysiology of neurological conditions and test potential treatments

FAQs

Q: What kind of basic neuroscience research tools do you offer for neuroscience research?

A: We offer a wide range of neuroscience research tools including antibodies, cell lines, viral vectors, small molecules, and biosensors. These tools are specifically designed for use in areas like neural tracing, neuroimaging, electrophysiology, and neurobehavioral studies. Whether you are investigating neural circuits, neurotransmitter dynamics, or specific neuronal populations, our products can cater to diverse experimental requirements. We also provide custom solutions tailored to your unique research goals.

Q: Can I receive technical support or protocol guidance for using your neuroscience research tools?

A: Absolutely! We offer comprehensive technical support to help you get the best results from our neuroscience research tools. Our experienced scientists are available to provide protocol guidance, troubleshoot experiments, and suggest best practices. We also have extensive online resources, including application notes, user manuals, and troubleshooting guides. If you encounter any challenges, our team is here to assist you from experiment planning through data analysis.

Q: Are your neuroscience research tools compatible with common laboratory systems and platforms?

A: Yes, our neuroscience research tools are designed to be compatible with widely used laboratory systems and platforms. Whether you're using imaging systems like confocal microscopes, electrophysiology rigs, or molecular biology workflows, our products integrate smoothly into your existing setup. We also ensure that our reagents and assays align with standard neuroscience methodologies, reducing the need for optimization and streamlining your experimental processes.

Q: What is the average delivery time for your neuroscience research tools, especially custom orders?

A: For standard products, the average delivery time is typically between 3 to 7 business days, depending on your location and the availability of the item. Custom orders usually take longer, with lead times varying based on the complexity of the customization. For example, custom viral vector production or antibody modifications may take 2 to 4 weeks. We always provide an estimated delivery timeline when you place an order and keep you informed of any updates.

Scientific Resources

Neuroimaging as a Tool for Modeling CNS Diseases

Emerging Tools for the Study of Neurological Diseases - Brain Organoids

For Research Use Only. Not For Clinical Use.