Online Inquiry

Cell-based Neural Model Products

Features Roles Portfolio Advantages FAQs Related Product Sections Product List

Introduction

Indispensable in vitro paradigms, cellular neuro-models elucidate nervous system complexities and propel drug discovery, overcoming traditional model limitations with human relevance, scalability, and genetic manipulability. Validated iPSC-derived or engineered neural cells recapitulate neurophysiology/pathology with superior translatability—fundamental for mechanistic studies, target identification, drug assessment, and accelerating neurological treatment development.

Creative Biolabs advances neuroscience by providing meticulously characterized, adaptable cell-based neural models. Our state-of-the-art, physiologically congruent systems aid investigation of intricate neurobiological phenomena, therapeutic screening, and expediting interventions for diverse neurological conditions. Contact our expert team for a personalized consultation and quote!

You may also directly consult our comprehensive Product List for specific offerings.

Advantages of Choosing Creative Biolabs

Choosing the right cell-based models is paramount to the success of your neuroscience research. Creative Biolabs is not just a supplier; we are your dedicated research partner, committed to providing solutions that accelerate your journey from discovery to clinical application.

The Power of Cell-based Neural Models in Modern Neuroscience

Creative Biolabs is dedicated to providing the scientific community with advanced neural models that push the boundaries of what's possible in understanding and treating brain disorders.

Applications	Description
Disease Modeling	Recreating the cellular and molecular hallmarks of neurological and psychiatric disorders (e.g., Alzheimer's disease, Parkinson's disease, Autism Spectrum Disorder, Schizophrenia) to investigate pathogenic mechanisms and identify novel therapeutic targets.
Drug Discovery and Development	High-throughput screening of compound libraries to identify potential drug candidates, assess their efficacy, and evaluate mechanisms of action.
Neurotoxicity Testing	Evaluating the potential adverse effects of novel chemical entities, environmental toxins, or existing drugs on neuronal health and function, providing critical data for safety assessments.
Developmental Neurobiology	Studying the fundamental processes of neural development, differentiation, migration, and synaptogenesis.

Categories of Our Cell-based Neural Model Products

We offer an extensive selection of cell-based neural models to cater to diverse research applications:

Wild Type Neural Models:
- Representing the normal, non-modified state, ideal as controls and for studying fundamental neural biology. Includes primary neurons, astrocytes, microglia, and oligodendrocytes from various species.
iPSC-derived Neural Models:
- Human induced Pluripotent Stem Cell (iPSC)-derived neurons, astrocytes, microglia, oligodendrocytes, and neural stem cells. These models offer a powerful platform for studying human-specific neurological diseases and patient-specific responses.
Immortalized Neural Models:
- Cell lines that have been modified to proliferate indefinitely while retaining key characteristics of their neural cell type. Ideal for high-throughput screening and large-scale studies.
Cas9 Neural Models:
- Neural cell lines stably expressing Cas9 nuclease, ready for guide RNA (gRNA) delivery to facilitate targeted gene editing. Streamlines the creation of custom knock-out or knock-in models.
Reporter Neural Models:
- Engineered to express reporter genes (e.g., GFP, RFP, Luciferase) under the control of specific neural promoters or linked to genes of interest. Enable real-time monitoring of gene expression, cell signaling, and other cellular events.
Knock-Out (KO) Neural Models:
- Specific genes are permanently inactivated using gene editing technologies like CRISPR/Cas9. Essential for studying gene function and validating drug targets in a neurological context.
Knock-In (KI) Neural Models:
- Specific genetic sequences (e.g., disease-associated mutations, reporter tags) are inserted into a precise locus in the genome of neural cells. Crucial for modeling genetic disorders and tracking protein dynamics.
Overexpression Neural Models:
- Genetically engineered to overproduce specific proteins of interest. Useful for investigating the effects of increased gene dosage or protein activity in neural function and disease.

A picture that presents novel and classical adult neurogenic zones, as well as their main cellular stages. (OA Literature)

Fig.1 Schematic representation of "novel" and classical adult neurogenic zones, as well as their main cellular stages.¹

FAQs

What types of research can benefit from your neural models?
Our models are crucial for disease modeling (e.g., Alzheimer's, Parkinson's), drug discovery and development, neurotoxicity testing, developmental neurobiology studies, and advancing personalized medicine.
Do you offer custom neural model development?
Yes, Creative Biolabs specializes in custom neural model development. We can create models with unique genetic modifications, specific cell backgrounds, or novel features tailored to your research objectives.
What is the advantage of using iPSC-derived Neural Models?
The principal advantage of employing neural models derived from induced pluripotent stem cells (iPSCs) resides in their unique capacity for autologous or patient-specific disease recapitulation. Such systems facilitate rigorous elucidation of genetic etiologies underlying neurological disorders. Furthermore, they provide an unparalleled platform for advancing personalized therapeutic strategies.
When would I need an Immortalized Neural Model?
Immortalized neural model systems present an optimal solution under specific experimental exigencies; their application is particularly indicated for high-throughput screening paradigms and for longitudinal investigations demanding homogenous cellular cohorts over protracted durations. Moreover, when the procurement of primary neural tissues is substantially constrained, these models become invaluable. The foundational advantages underpinning their utility are an indefinite, or significantly extended, proliferative potential coupled with the faithful retention and expression of essential, lineage-specific neurophysiological characteristics critical for relevant study.
How can I get started or discuss a custom project?
The initiation of collaborative projects or the exploration of bespoke neural model development with Creative Biolabs may proceed via distinct, clearly defined avenues. A comprehensive examination of the organization's extensive product and service portfolio is readily accessible through their designated institutional website. Alternatively, direct scientific consultation—essential to delineate specific research objectives or to conceptualize and refine tailored project designs—can be effectively arranged by establishing contact with their specialist scientific liaison team.

The complexity of the nervous system demands innovative tools and expert partners. Creative Biolabs is committed to empowering your research with the highest quality cell-based neural models and unparalleled scientific support. Whether you are exploring fundamental neurobiology, unraveling disease mechanisms, or pioneering new therapies, our models provide the reliable, physiologically relevant systems you need to succeed.

Discover the Creative Biolabs difference. Contact us to discuss your custom project needs. Let us help you accelerate your next breakthrough in neuroscience.