GABAergic Neuron Progenitor Differentiation

GABAnergic neurons are essential for human neurologic function in human central nervous system (CNS) while primary GABAnergic neurons are hard to obtain. With the emergence of iPSC technology, iPSC-derived GABAergic neurons provide researchers with rich research materials to explore their biological functions. Creative Biolabs offers custom GABAnergic neuron differentiation service to generate high-quality GABAnergic neurons for worldwide scientists to ease their research.

Introduction of GABAnergic Neuron

In mammal CNS, gamma-aminobutyric acid (GABA) is a primary inhibitory neurotransmitter to reduce neuronal excitability via inhibiting transmission of nerve signals. GABAnergic neurons, existing in multiple regions of brain like thalamus, basal ganglia, and brainstem, indicate the neurons with capacity of producing GABA. GABAnergic neurons play significant roles in different pathophysiological functions such as information processing and integration, brain circuitry and activity, and cognitive function, whose dysfunction mediated neurotransmission leads to several neurodevelopmental and neurodegenerative disorder like epilepsy and Alzheimer's disease (AD).

Fig.1 The role of GABAnergic neurons in AD.¹

Custom GABAnergic Neuron Differentiation

The iPSC technology provides an attractive way for modelling human embryonic development in vitro without violation of ethics. Here, strong evidence demonstrates that iPSCs can quickly produce high-purity and functional GABAnergic neurons, which offering a unique platform for researching GABAnergic neuron-related pathophysiology and disease treatment. Creative Biolabs establishes the efficient GABAnergic neuron differentiation platform from human iPSC. The generated GABAnergic neurons show typical neurite outgrowth, marker gene expression profile, and producing GABA. We present a simple and fast method for converting your iPSC line into GABAnergic neurons, available for producing defective GABAnergic neurons when combined with gene editing tool.

Fig.2 Immunofluorescence staining of our iPSC-derived GABAnergic neurons.

Features of Our Service

• High compatibility and success rate with iPSC cell lines.
• Customized production and attractive price.
• High purity and repeatability.
• Fast delivery and best after-sale service.

Creative Biolabs, with years of experience in neural field, establishes iPSC-derived GABAnergic neuron platform producing unlimited resource of GABAnergic neurons to speed up your critical research progress. For all your questions and needs regarding custom GABAnergic neuron, please feel free to contact us for more details.

Reference

1. Xu, Yilan, et al. "GABAergic inhibitory interneuron deficits in Alzheimer's disease: implications for treatment." Frontiers in neuroscience 14 (2020): 660. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only. Not For Clinical Use.