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Reporter Neural Models Products

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Revolutionizing Neuroscience Research with Advanced Cellular Models

Creative Biolabs is at the forefront of innovation, offering the scientific community cutting-edge tools to unravel nervous system complexities. Understanding neural development, function, and pathology is crucial for developing therapies for neurological disorders. While traditional methods have limitations in mimicking in vivo events, our reporter neural model cell products provide a transformative leap: dynamic, quantifiable, and high-throughput-compatible systems that illuminate these processes with clarity.

Creative Biolabs, your trusted partner, provides a comprehensive portfolio of meticulously engineered reporter neural cell lines. These models empower diverse research, from fundamental neurogenesis studies to high-throughput drug screening for neurological disorders. Contact us to learn how our solutions can advance your research. Inquire for a personalized quote for your specific needs.

You may also directly consult our comprehensive Product List for specific offerings.

Types of Reporter Neural Models

Creative Biolabs offers a diverse range of Reporter Neural Model Cell Products, each designed to meet specific research needs. Understanding their variations can help you select the optimal tool for your project.

Types	Description
Fluorescent Reporter Lines (e.g., GFP, RFP)	Ideal for live-cell imaging, cell tracking, and FACS-based isolation of specific populations like Nestin-EGFP+ neural progenitors or DCX-EGFP+ early neurons.
*Luminescent Reporter Lines (e.g., Firefly Luciferase)*	Offer high sensitivity for quantitative assays and HTS, such as FMR1-Nluc for gene reactivation studies or Tal-promoter lines for general neuronal activity.
Varied Cell Backgrounds	hESC/hiPSC-Derived: Human models for developmental and disease studies. Immortalized Lines (e.g., NTERA-2): Easy-to-culture systems for initial screenings. MSCs: For transdifferentiation and cell therapy research.
Promoter-Specific Lines	Targeting distinct neural stages or types using promoters like Nestin (progenitors), DCX (immature neurons), Tal/Tuj1 (general neurons), or FMR1 (Fragile X studies). Custom promoters for specific subtypes (e.g., dopaminergic) can also be developed.

Key Features and Advantages of Creative Biolabs' Reporter Neural Models

Physiological Relevance

Our models, especially iPSC-derived lines, closely mimic human neural biology and disease states.

High Sensitivity & Specificity

Carefully selected promoters and advanced reporter systems (like NanoLuciferase for enhanced brightness and sensitivity) ensure accurate and robust signal detection.

Genetic Stability & Reproducibility

Stringent quality control, including karyotyping for iPSCs and validation of reporter expression and function, guarantees reliable and reproducible results.

HTS-Compatibility

Our reporter cell lines are optimized for high-throughput screening in various formats, including 96-well, 384-well, and 1536-well plates, enabling rapid identification of lead compounds.

Versatility

Suitable for a wide array of applications, from basic research into molecular mechanisms to translational drug discovery.

Expert Support

Our dedicated team of neuroscientists and cell biologists provides comprehensive technical support and consultation to help you achieve your research goals.

Diverse Applications Driving Neurological Breakthroughs

Creative Biolabs' reporter neural models are empowering research across numerous domains:

Applications	Description
Neurodegenerative Disease Modeling	Study the pathogenesis of Alzheimer's, Parkinson's, Huntington's, ALS, Fragile X Syndrome, and other neurological disorders.
Drug Discovery & High-Throughput Screening	Identify neuroprotective compounds. Discover molecules that promote FMR1 gene reactivation or modulate other disease-relevant genes. Screen for agents that enhance neuronal differentiation or regeneration.
Mechanistic Studies of Neurogenesis & Neuronal Development	Investigate the signaling pathways, transcription factors (like Ngn2), and epigenetic modifications that govern cell fate decisions, neurite outgrowth, and synaptogenesis.
Neurotoxicity Assessment	Evaluate the potential adverse effects of compounds on neuronal health and function.
Development of Cell-Based Therapies	Optimize differentiation protocols and assess the functionality of cells intended for transplantation.

A picture that presents Neural markers and glial markers. (Li, et al., 2009) (OA Literature)

Fig.1 Neural markers and glial markers were expressed in early spheres.¹

FAQs

Which neural cell types can your reporter models represent?
Our portfolio includes models for neural progenitor cells (NPCs), specific neuronal subtypes (e.g., dopaminergic, motor neurons), astrocytes, and oligodendrocytes, derived from hESCs, iPSCs, or MSCs.
Can I request a custom-made reporter neural model?
Yes, Creative Biolabs offers custom cell line development services. We can tailor a reporter model to your specific gene of interest, cell type, and reporter protein.
How do these reporter models compare to traditional methods like qPCR or Western blotting?
Reporter models offer the advantage of live-cell, real-time analysis and are often more sensitive and less labor-intensive for high-throughput applications. They complement traditional methods by providing dynamic information.
Do you offer reporter lines for specific neurological diseases?
Yes, we have iPSC-derived reporter lines from patients with various neurological conditions, or we can engineer reporters into existing patient-derived iPSC lines.
Can these cells be used for in vivo studies?
While primarily designed for in vitro work, some reporter systems (especially those with bright and stable fluorescent proteins or bioluminescent reporters suitable for in vivo imaging) can potentially be adapted for transplantation and in vivo tracking studies. Please discuss your specific needs with our team.

Creative Biolabs' Reporter Neural Model cell products provide an insightful, efficient, and reliable way to study neural biology, model disease, and screen for novel therapeutics. Our commitment to scientific excellence and cutting-edge technology ensures you receive high-quality, well-characterized tools to power your next breakthrough.

Contact us today to discuss your specific research needs, request a custom quote, or explore our extensive catalog of reporter neural cell lines. Let's collaborate to shape the future of neuroscience.