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TDP-43 Gene-Engineered Cell Models Products

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TDP-43 is a key RNA metabolism protein that is implicated in ALS and FTLD. Accurate cell models are vital for understanding these diseases and developing therapies. Creative Biolabs offers advanced TDP-43 gene-edited cell models. These models precisely introduce disease-associated mutations or modifications into cell lines, enabling accurate recapitulation of disease phenotypes. Researchers can investigate mechanisms and screen therapeutics, accelerating treatment development. Scientific literature supports these models; for instance, studies indicate that ALS-linked TDP-43 mutations enhance protein stability and promote toxic complex formation, while also causing aberrant RNA splicing and motor neuron disease. Our models provide a valuable platform for further exploring TDP-43 proteinopathies. To accelerate your research on TDP-43-related neurodegeneration, we invite you to request a quote now.

You can explore our TDP-43 model categories below, or view our complete Product List.

Featured TDP-43 Gene-Engineered Cell Model Categories

At Creative Biolabs, we have many TDP-43 cell models. They are grouped by how they work.

TDP-43 Mutation Models: These models have specific TDP-43 gene changes seen in patients with ALS and FTLD. They help study the exact problems these changes cause. You can see how they affect what the TDP-43 protein does, how it processes RNA, and other things in the cell.
TDP-43 Knock-in Models: Our knock-in models let you put the TDP-43 gene in a specific place in the cell's DNA. This helps you study how much TDP-43 is made and what it does in a controlled way. These models are very useful for seeing how disease changes affect how TDP-43 interacts with other proteins, where it goes in the cell, and how it changes RNA.
TDP-43 Knock-out Models: In these models, the TDP-43 gene is turned off. So, the cell does not make any TDP-43 protein. Scientists use these models to learn what TDP-43 normally does. They also study what happens when TDP-43 is missing, like changes in RNA, stress granules, and autophagy. These models can also help find new drug targets to fix the problems caused by losing TDP-43.
TDP-43 Overexpression Models: These cell lines make too much TDP-43 protein. This is like what happens in the disease. These models help study how too much TDP-43 can be harmful. This includes protein clumping, problems with breaking down proteins, and problems with mitochondria.
TDP-43 Tagged Cell Lines: TDP-43 tagged cell lines are very helpful with animal studies. Animal studies show how ALS affects the whole body. But our cell models let you look closely. You can see the small things happening inside cells. This is in a clear and controlled way. When you use both our cell models and animal studies together, you understand the disease better. This can help find better ways to treat it.

Features of Our TDP-43 Gene-Engineered Cell Models

Our TDP-43 gene-engineered cell models are characterized by:

Feature	Description
Precise Gene Modification	Utilizing cutting-edge gene-editing technologies to introduce specific TDP-43 alterations with high accuracy, minimizing off-target effects.
Disease Relevance	Replicating key aspects of TDP-43 proteinopathies, closely mimicking the cellular and molecular changes observed in ALS, FTLD, and other neurodegenerative diseases.
Versatility	Offering a wide range of models, including knockout, knock-in, and overexpression, to accommodate diverse research objectives and experimental designs.

Advantages of Our TDP-43 Gene-Engineered Cell Models

Enhanced Model Relevance: Our cell models are very good at copying the gene changes and cell conditions of TDP-43 diseases. This means they give you a more correct and real way to study how the disease works. You can also use them to test possible treatments.
Increased Experimental Efficiency: Using well-characterized cell lines makes experiments easier and less variable. This improves how consistent and repeatable your research results are. It helps you get good data more easily. Then you can focus more on making new scientific discoveries.
Accelerated Research Progress: Our cell models are strong and dependable for studying TDP-43 problems. Because of this, researchers can get results faster and be more sure of them. This quick progress helps us understand how the disease develops better. It also speeds up the creation of new treatments.
Complementary to In Vivo Studies: Our gene-edited cell models can work with animal studies. Animal studies show how TDP-43 problems affect the whole body. But our cell models let you see the small details inside cells. You can see what happens with molecules in a clear way. When you use both our cell models and animal studies, you get a better idea of the disease. This can help find better ways to treat it.

A picture presents TDP-43's mutations. (OA Literature)

Fig.1 TDP-43's domain organization depicting ALS and FTLD-linked mutations. ¹

TDP-43 Gene: Mechanisms and Principles

Our cell models are based on a deep understanding of the genetic mechanisms underlying TDP-43 proteinopathies. TDP-43 is a DNA-binding protein that regulates gene expression and RNA processing. Mutations in the TDP-43 gene can lead to a variety of pathological changes, including:

Increased TDP-43 stability: ALS-linked mutations can increase the stability of TDP-43 protein, leading to its accumulation in cells.
Abnormal protein interactions: Mutant TDP-43 may interact abnormally with other proteins, such as FUS/TLS, disrupting their normal functions.
Aberrant RNA splicing: TDP-43 mutations can disrupt the normal splicing of RNA molecules, leading to the production of dysfunctional proteins.
Mitochondrial dysfunction: TDP-43 has been found to localize to mitochondria, and mutations may impair mitochondrial function, contributing to neurodegeneration.

FAQs

Are these cell models suitable for drug screening?
Yes, our TDP-43 cell models are good for drug screening. They let you see if drugs work and are safe. You can trust the results. If you want help setting up drug tests, just ask us.
What are the shipping and storage conditions for the cell models?
We freeze our cell models and send them on dry ice. This keeps them stable and alive. When you get them, you should put them in liquid nitrogen. Or, you can use them right away. Just follow the directions we send with them.
Can the TDP-43 cell models be used for in vivo studies?
We mainly made our cell models for lab research. But you can also use them in living things, like to make xenografts. You would just need to check that they work right for that first.
Can you create custom TDP-43 cell models with specific mutations or modifications?
Yes, we can make custom TDP-43 cell models for you. They can have the exact mutations or changes you need. Please get in touch with us. Then we can talk about what you want for your research.
Do you offer cell models for other neurodegenerative diseases?
Yes, we also have cell models for other brain diseases. We offer many gene-edited cell models. These models cover diseases like Alzheimer's, Parkinson's, and Huntington's.

Our TDP-43 cell models are strong tools. They help speed up research on ALS, FTLD, and other brain diseases. They also help make good treatments. We want to give researchers cell models that are trustworthy, correct, and new. These models can help us learn more about these terrible diseases. Contact us today. Tell us what you need for your research. Let's see how our TDP-43 cell models can help you make your next big discovery.