STEMOD™ Neuroscience Ex Vivo Models Services

• Custom Neural Differentiation Service
• Custom Brain Spheroid
• Custom Brain Organoid Services
• Custom CNS Disease Modeling Services
• Blood-Brain Barrier Model

Introduction of Neuroscience

Neuroscience, also known as neurobiology, is the scientific study of the structure and function of the nervous system. Combined with multiple disciplines, it focuses on the study of the nervous system with different approaches and different scales. Neural tissue damage in the peripheral nervous system (PNS) and central nervous system (CNS) may result in multiple neurological diseases and even life-long disabilities. Neural tissue engineering is a promising strategy for neural repair and neurological diseases treatment. In this case, proper preclinical models are required to mimic the micro-environment. Here, Creative Biolabs has developed the STEMOD™ neuroscience ex vivo models for our clients all over the world.

Fig.1 Neurosphere in vitro models. (Mobini 2019)

Organotypic Brain Slice Model

Ex vivo models are mainly developed from primary neuronal cultures or induced pluripotent stem cells derived from patients. Organotypic brain slice cultures have been used for the research of neurodegenerative disorders, such as Huntington's disease (HD), Parkinson's disease, brain stroke, and cerebral ischemia. Compared with in vivo and in vitro platforms, they preserve tissue structures, neuronal activities, synapse circuitry, and in vivo environments. The unique advantages also include low cost, maintenance in culture for weeks, as well as rapid and simple use. Recent studies showed that a series of neuroscience organotypic models have been developed using transgenic mice or wild-type rodents. What's more, the lab-on-a-chip device is also an excellent choice.

Fig.2 Ex vivo models for neural regeneration and engineering. (Mobini, 2019)

Functions of Neuroscience Ex vivo Models

• Elucidate the pathogenesis
• Research for cell death mechanisms
• Evaluate therapeutic potential of innovative strategies
• High-throughput screening of neuroactive molecules

Advantages of Neuroscience Ex vivo Models

• Simple and rapid to perform
• The reduction of the high costs of research in vivo
• Precision and accessibility
• Control of the extracellular environment
• Greater mechanical stability
• Avoid ethical issues to a greater extent

Services at Creative Biolabs

Based on our advanced neuroscience translation and assays platform, the STEMOD™ neuroscience ex vivo models can be generated from cells, transgenic mice, aged rats, and mice. For your neurological diseases research, we can further provide actionable data and a novel approach to drive your drug development from early discovery through late-stage preclinical. For different research purposes, we can provide services that include but are not limited to:

• Custom Neural Differentiation Service
• Custom Brain Spheroid
• Custom Brain Organoid Services
• Custom CNS Disease Modeling Services
• Blood-Brain Barrier Model

As a global company with extensive scientific expertise, Creative Biolabs is professional in applying advanced platforms for a broad range of neurosciences research, now we provide the novel STEMOD™ neuroscience ex vivo models for our clients all over the world. If you are interested in our services and products, please do not hesitate to contact us for more detailed information.

Service Features

We offer highly tailored solutions to meet our clients' needs. We work closely with our clients to develop and deliver specific models that are suited to their research purposes.

Our services are comprehensive. From project design and planning to execution and data interpretation, we support our customers every step of the way. Creative Biolabs provides researchers with advanced tools and support to advance our understanding of the brain and develop novel therapeutics for neurological disorders.

Applications

Our STEMOD™ neuroscience ex vivo models services offer a versatile platform for advancing neuroscience research, drug discovery, and therapeutic development, with the potential to address critical unmet needs in understanding and treating neurological disorders.

• Novel Therapeutics Research
  The use of ex vivo models to screen potential drug candidates for the treatment of neurological disorders such as Alzheimer's disease, Parkinson's disease or epilepsy. These models help decipher the cellular and molecular mechanisms of neurological diseases and develop and test potential new drugs or therapies.
• Disease Modelling
  Generate ex vivo models that mimic specific neurological diseases or conditions to study disease mechanisms, identify biomarkers, and test potential therapeutic interventions. These models can be customized to replicate aspects of neurodegeneration, neuroinflammation or neurodevelopmental disorders.
• Neurotoxicity Testing
  Businesses designing new medications can utilize these models for neurotoxicity testing, ensuring the safety-profile of the new compounds.

These applications highlight the versatility of services in advancing research, drug discovery, and our understanding of the complexities of the nervous system. The specific offerings and capabilities would depend on the technologies and models we develop.

FAQs

• Q: What types of experiments can be conducted using your ex vivo models?
  A: Our ex vivo models are versatile and can be used for a wide range of experiments, including studying synaptic function, neurotoxicity assays, drug screening, electrophysiological recordings, and investigating disease mechanisms in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
• Q: How do you ensure the quality and integrity of these ex vivo models?
  A: Quality is our utmost priority. We ensure the integrity of our models through strict protocols, regular testing, and quality control. Each model undergoes a thorough validation process to ensure it accurately represents the cellular and molecular characteristics of the neuron it's designed to model.
• Q: How long can the ex vivo models be maintained in culture?
  A: The longevity of our ex vivo models depends on various factors such as the specific model type, culture conditions, and experimental requirements. Generally, brain slice cultures and organotypic slice cultures can be maintained for several weeks to months while primary neuron cultures can be sustained for up to several weeks with proper maintenance.
• Q: Can you provide references or case studies demonstrating the efficacy of your ex vivo models?
  A: Yes, we can provide references and case studies showcasing the efficacy of our ex vivo models in various research applications. Simply contact our team to get detailed resources. These resources demonstrate the utility and reliability of our models for advancing scientific understanding in the field of neuroscience.
• Q: What is the cost of service?
  A: The cost largely depends on the specifications and complexity of the model needed. We encourage you to reach out to us with your project details and we'd be more than happy to provide you with a customized quote.

Scientific Resources

How to Build Brain Models?

How to Make Neuron Models?

References

1. André, E.; et al. A novel ex vivo Huntington's disease model for studying GABAergic neurons and cell grafts by laser microdissection. Plos one. 2018, 13(3): e0193409.
2. Mobini, S.; et al. Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering. Biomaterials. 2019, 198: 146-166.

For Research Use Only. Not For Clinical Use.