Neuroscience, also known as neurobiology, is the scientific study of the structure and function of the nervous system. Combined with multiple disciplines, it focuses on the study of the nervous system with different approaches and different scales. Neural tissue damage in the peripheral nervous system (PNS) and central nervous system (CNS) may result in multiple neurological diseases and even life-long disabilities. Neural tissue engineering is a promising strategy for neural repair and neurological diseases treatment. In this case, proper preclinical models are required to mimic the micro-environment. Here, Creative Biolabs has developed the STEMOD™ neuroscience ex vivo models for our clients all over the world.
Fig.1 Neurosphere in vitro models. (Mobini 2019)
Organotypic Brain Slice Model
Ex vivo models are mainly developed from primary neuronal cultures or induced pluripotent stem cells derived from patients. Organotypic brain slice cultures have been used for the research of neurodegenerative disorders, such as Huntington's disease (HD), Parkinson's disease, brain stroke, and cerebral ischemia. Compared with in vivo and in vitro platforms, they preserve tissue structures, neuronal activities, synapse circuitry, and in vivo environments. The unique advantages also include low cost, maintenance in culture for weeks, as well as rapid and simple use. Recent studies showed that a series of neuroscience organotypic models have been developed using transgenic mice or wild-type rodents. What's more, the lab-on-a-chip device is also an excellent choice.
Fig.2 Ex vivo models for neural regeneration and engineering. (Mobini, 2019)
Functions of Neuroscience Ex vivo Models
Elucidate the pathogenesis
Research for cell death mechanisms
Evaluate therapeutic potential of innovative strategies
High-throughput screening of neuroactive molecules
Advantages of Neuroscience Ex vivo Models
Simple and rapid to perform
The reduction of the high costs of research in vivo
Precision and accessibility
Control of the extracellular environment
Greater mechanical stability
Avoid ethical issues to a greater extent
Services at Creative Biolabs
Based on our advanced neuroscience translation and assays platform, the STEMOD™ neuroscience ex vivo models can be generated from cells, transgenic mice, aged rats, and mice. For your neurological diseases research, we can further provide actionable data and a novel approach to drive your drug development from early discovery through late-stage preclinical. For different research purposes, we can provide services that include but are not limited to:
As a global company with extensive scientific expertise, Creative Biolabs is professional in applying advanced platforms for a broad range of neurosciences research, now we provide the novel STEMOD™ neuroscience ex vivo models for our clients all over the world. If you are interested in our services and products, please do not hesitate to contact us for more detailed information.
André, E.; et al. A novel ex vivo Huntington's disease model for studying GABAergic neurons and cell grafts by laser microdissection. Plos one. 2018, 13(3): e0193409.
Mobini, S.; et al. Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering. Biomaterials. 2019, 198: 146-166.