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Ion Channel Screening Services

Ion channels are important pharmacological targets for drug intervention and treatment of disorders in the central nervous system (CNS). Equipped with cutting-edge technology and experts using the most up-to-date methodologies, Creative Biolabs is your ion channel screening program partner to meet all your specific requirements.

Introduction to Ion Channels as Therapeutic Targets

Ion channels regulate crucial electrical functions throughout the body, including the heartbeat, sensory transduction, and CNS function. Given the central role in many physiological processes, they represent an attractive target class for drug discovery. They are enormous potential for the intervention of disease states in various disorders, particularly in the CNS and cardiovascular systems. The recognized importance of ion channel proteins in health and disease has led to an active search for ion channel targets and novel therapeutics in the worldwide drug discovery market.

Ion Channel Screening

Ion channels underlie numerous physiological processes and present unique challenges in drug discovery screening, owing to complex multisubunit architectures and practical considerations when measuring their activity with any degree of throughput. Therefore, high-throughput ion channel screening technologies are commonly utilized for ion channel drug discovery. Recently, two major and highly complementary strategies have formed the basis for cell-based ion channel screening: the highest throughput optical assays representing indirect measures of ion channel function and the introduction of higher-throughput electrophysiological methodologies. These approaches permit an efficient and integrated process for ion channel drug discovery.

  • First, non-electrophysiological approaches such as ion flux measurements directly and optical approaches to ion flux and membrane potential measurements are established and validated. Ion-flux methods have been used successfully to identify many ion channel modulators.
  • Second, ion channel function can be monitored using membrane potential-sensitive fluorescent dyes in fluorescence-based assays.
  • In addition, ion channel screening would be greatly facilitated by developing novel, HTS-compatible assays with improved voltage control and kinetic resolution based on electrophysiological screening technologies. The ability to study ion channels by voltage clamp and their drug interactions with enhanced throughput plays a key role in the development of novel ion channel-targeted drugs.

Schematic of the evolution of the electrophysiological patch-clamp technology for ion channel screening.

Services at Creative Biolabs

With increased recognition of the importance of ion channels in disease processes, the last ten years have witnessed tremendous progress in functional ion channel-screening technologies and their implementation for ion channel drug discovery. The current functional screening technologies have been advanced to a point where understanding of the biology and pathophysiological relevance of ion channels in a disease context and the design of enhanced ion channel-targeted chemical libraries become the rate-limiting factors for meaningful drug discovery. For this fast-paced area of research, Creative Biolabs provides state-of-the-art ion channel screening solutions to researchers all over the world. Our system provides a platform for fully automated high-throughput screening and pharmacological characterization of ion channel modulators. We look forward to discussing the projects and finding the best solution for your needs.

Ion channels are attractive targets for drug discovery in CNS. With our advanced platform and extensive experience, Creative Biolabs is confident in offering the best ion channel screening services. We guarantee the results for our customers all over the world. Please do not hesitate to contact us or reach us by e-mail or phone with your particular needs.

For Research Use Only. Not For Clinical Use.