Online Inquiry

Nurr1 Gene-Engineered Cell Models Products

Categories Features Advantages Mechanisms FAQs Related Product Sections Product List

Neurodegenerative diseases, such as Parkinson's and Alzheimer's, pose a significant challenge to global health. A deeper understanding of the underlying molecular mechanisms is crucial for developing effective therapies. We recognize the pivotal role of Nuclear Receptor Related 1 (Nurr1) in the development, function, and survival of dopaminergic neurons and its implications in neurological disorders. Our Nurr1 Cell Models are strong tools. They are made to help your research in this important area go faster. Please contact us. We can talk about how to make these tools best for your specific research needs in brain diseases.

You can explore our Nurr1 model categories below, or view our Product List.

Featured Nurr1 Gene-Engineered Cell Model Categories

Creative Biolabs has many Nurr1 Gene-Engineered Cell Models. These include:

Nurr1 Mutated Cell Lines: These models incorporate specific Nurr1 mutations found in neurological diseases, allowing for the study of their pathogenic mechanisms. The Ser125Cys mutation may influence phosphorylation and occurs in the N-terminal domain. Furthermore, it could affect transcriptional activity. Mutations can also arise in the ligand-binding domain (LBD). These changes can disrupt protein-protein interactions. Consequently, Nurr1 function may be affected.
Nurr1 Knockout Cell Lines: These models facilitate the investigation of Nurr1 loss-of-function and its contribution to neurodegeneration. We precisely knocked out the Nurr1 gene, leading to a complete absence of Nurr1 protein. These knockout models are essential for validating the specificity of Nurr1 inhibitors. Researchers can study the consequences of Nurr1 deficiency on neuronal development and maintenance. They can also model disease states in which Nurr1 expression is lost. Specifically, these cell models can help explain how losing Nurr1 makes certain brain cells weak. These brain cells make dopamine. This weakness is a key sign of Parkinson's disease.
Nurr1 Knock-in Cell Lines: Nurr1 knock-in cell lines are engineered to express modified Nurr1, like fluorescently tagged versions, enabling detailed studies of its localization and interactions. These models, sometimes created in Nurr1-deficient backgrounds for rescue experiments, restore Nurr1 function to elucidate its roles. Furthermore, Nurr1 can be introduced into non-neuronal cells to explore its broader impact, while reporter gene knock-ins within the Nurr1 locus illuminate its regulatory mechanisms even in initially Nurr1-negative cells.
Nurr1 Reporter Cell Lines: These models are designed to study Nurr1 transcriptional activity and its response to various stimuli. By incorporating a reporter gene, such as luciferase/GFP, under the control of Nurr1-responsive DNA elements, these cell lines provide a quantitative and highly sensitive measure of Nurr1 activation. Researchers can employ these models to screen for compounds. These compounds can modulate Nurr1 activity. They can also utilize them to investigate the signaling pathways. These pathways regulate Nurr1. Furthermore, these models enable the elucidation of factors. These factors influence Nurr1 expression and function. Additionally, these reporter cell lines can be engineered. This allows them to express other proteins. They can also express signaling pathway components. Consequently, scientists can study how these factors interact with Nurr1. This helps understand their influence on Nurr1 transcriptional activity.
Nurr1 Overexpression Cell Lines: These models enable the study of Nurr1 gain-of-function and its downstream effects on neuronal pathways. By introducing additional copies of the Nurr1 gene or strong promoters, we create cell lines with markedly elevated Nurr1 levels. Scientists can use them to understand the signals Nurr1 starts. They can also find the genes Nurr1 controls. And they can study if more Nurr1 helps neurons live or work better. Also, these models can help find drugs. These drugs might increase Nurr1 levels. This could help when Nurr1 is low in diseases. Nurr1 also controls other proteins. These proteins affect how mitochondria work. Examples include Pituitary homeobox 3 and Wnt/beta-catenin. These also control how certain brain cells are made. So, these models can help study how Nurr1 and these other proteins work together.

Features of Our Nurr1 Gene-Engineered Cell Models

Feature	Description
High Specificity	Engineered with advanced gene-editing for precise Nurr1 targeting. This specificity ensures observed changes are directly attributable to Nurr1 modification, minimizing off-target effects and enhancing result reliability.
Disease Relevance	Models mimic key aspects of neurological diseases, incorporating relevant mutations, pathway alterations, and pathological hallmarks. They offer physiologically relevant platforms for studying disease mechanisms and identifying therapeutic targets.
Quality Assurance	Each cell line undergoes rigorous quality control, including karyotyping, viability assays, and functional validation, to ensure the highest quality and reliability.

Advantages of Our Nurr1 Gene-Engineered Cell Models

Reduce Variability: Ensure consistency and reproducibility in your experiments by using well-characterized and validated cell lines, minimizing the impact of cell line-specific variations on your results, and obtaining more reliable data, leading to greater confidence in your conclusions.
Cost-Effective: Save time and resources with our efficient cell line generation services, reduce the need for expensive reagents and labor associated with in-house cell line development, and optimize your budget allocation and maximize research output.
Expert Support: Benefit from our scientific expertise and technical assistance throughout your research process, receive guidance on experimental design, data interpretation, and troubleshooting, and maximize the success of your research with our dedicated support team.

A picture presents NURR1-regulated Neuroinflammation. (Al-Nusaif, et al., 2022) (OA Literature)

Fig.1 NURR1-regulated Neuroinflammation associated with PD.¹

Nurr1 Gene: Mechanisms and Principles

The Nurr1 gene provides instructions for creating a transcription factor, a protein that controls the activity of other genes. This protein is essential for the proper development, differentiation, and ongoing function of midbrain dopamine (DA) neurons, which are crucial for movement control.

Nurr1 works a bit differently than other similar proteins. Usually, these proteins need to attach to another molecule. But Nurr1 mostly works on its own. It directly attaches to specific parts of DNA. This controls how certain genes are read. These genes are involved in making dopamine. They also help with sending signals between neurons. And they help neurons stay alive.

In Parkinson's disease, the amount of Nurr1 often goes down. Or Nurr1 might not work as well. This suggests that Nurr1 is important for why the disease starts and gets worse.

FAQs

What is the significance of Nurr1 in Parkinson's Disease (PD)?
Impaired Nurr1 function contributes to DA neuron dysfunction and degeneration, key features of PD.
What cell types are available for the Nurr1 Gene-Engineered cell models?
We mainly use neuronal progenitor cells and iPSCs for our Nurr1 cell models. These cell types are very important for studying brain development problems. These are the cells we usually offer. However, we might have other cell types available too. Also, we can create specific cell types if your research needs them.
What are the applications of Nurr1 gene-engineered cell models?
You can use these models to study what Nurr1 does in several areas. One area is how dopaminergic neurons develop and work. Another is how Parkinson's disease starts. Also, they can help find and create new drugs for Parkinson's. Finally, they can help understand how to protect neurons.
How do Creative Biolabs' Nurr1 cell models reflect the in vivo situation of Parkinson's Disease?
While cell models cannot fully replicate the complexity of the brain, they provide a controlled environment to study specific molecular mechanisms of Nurr1 in PD, complementing in vivo studies.
How can I order Nurr1 gene-engineered cell models from Creative Biolabs?
You can order our cell models by contacting us through our online inquiry, email, or phone. Our team will help you order the products.

Creative Biolabs has advanced ways to edit genes. These methods create cell models that are exact and dependable. You can use them to study Parkinson's disease. You can also study other brain disorders. And you can investigate how cells use energy. You can do this with very high accuracy. Contact our team to learn more and talk to us about your project.