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iPSC-derived Neural Models Products

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The human nervous system, with its intricate complexity, presents profound challenges for researchers striving to understand neurological diseases and develop effective therapies. Traditional models often fall short of recapitulating human-specific physiology and pathology. At Creative Biolabs, we empower your research by providing cutting-edge, human induced pluripotent stem cell (iPSC)-derived neural models. These highly characterized and physiologically relevant cells offer an unparalleled window into human neurobiology, accelerating your journey from discovery to clinical translation. Our expert team is on hand to discuss your specific project needs and guide you to the optimal neural model solution. Contact us today for a personalized consultation or to request a quote.

You may also directly consult our comprehensive Product List for specific offerings.

Features

Our commitment to quality and scientific rigor ensures you receive cells that are:

Accelerating Your Neuroscience R&D: Key Applications

Creative Biolabs' iPSC-derived neural models provide powerful platforms to address critical questions across the spectrum of neuroscience research and development.

Precision Disease Modeling:

Neurodevelopmental Disorders (e.g., ASD, Rett Syndrome, Schizophrenia): Investigate early synaptic dysfunctions, altered neuronal connectivity, and imbalances in excitatory/inhibitory signaling using patient-derived cortical neurons and organoids. Our models allow for the study of how genetic and environmental factors contribute to these complex conditions.
Neurodegenerative Diseases (e.g., Alzheimer's, Parkinson's, ALS, SMA, Huntington's): Model key pathological hallmarks such as protein aggregation (e.g., Aβ, Tau, α-synuclein), neuronal vulnerability and death, axonal transport defects, and neuroinflammation. Study disease progression in patient-specific motor neurons for ALS and SMA, or dopaminergic neurons for Parkinson's disease.
Uncovering Novel Disease Mechanisms: Utilize patient-specific iPSC models to identify novel cellular phenotypes and molecular pathways that may have been missed by traditional approaches, leading to new therapeutic targets.

Transforming Drug Discovery and Development:

Target Identification and Validation: Use functional genomic screens or pathway analysis in disease-relevant iPSC-derived neural cells to identify and validate novel drug targets.
High-Throughput (HTS) and High-Content Screening (HCS): Our scalable iPSC-derived neural cell production, coupled with advanced High-Content Imaging (HCI) platforms (as highlighted in studies like PMC8225800), enables robust screening of compound libraries to identify potential therapeutic candidates based on phenotypic readouts (e.g., neurite outgrowth, synapse number, cell survival).
Efficacy Testing: Evaluate the therapeutic potential of lead compounds to rescue disease phenotypes in patient-derived neural models, providing critical preclinical evidence.
Neurotoxicity Assessment: Screen compounds for potential adverse effects on human neurons and glia early in the development pipeline, reducing the risk of late-stage failures.
Patient Stratification: Identify biomarkers in patient-derived cells that may predict drug response, enabling the design of more targeted and effective clinical trials.

Our Comprehensive Portfolio of iPSC-Derived Neural Cell Products

Creative Biolabs offers a diverse range of meticulously developed and validated iPSC-derived neural cells to meet the varied demands of modern neuroscience research.

1. Neural Progenitor Cells (NPCs)

Versatile, multipotent cells capable of differentiating into various neural lineages. Ideal for developmental studies, neurogenesis research, and as a foundational tool for generating more specialized cell types. Our NPCs are characterized for key markers like NESTIN, PAX6, and SOX2.

2. Specific Neuron Subtypes

Cortical Neurons (Excitatory & Inhibitory): Including glutamatergic and GABAergic neurons, essential for modeling complex cortical circuitry, neurodevelopmental disorders (e.g., Autism Spectrum Disorder), and neurodegenerative conditions affecting the cortex.
Motor Neurons: Crucial for studying motor neuron diseases such as Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), and for research into neural injury and regeneration.
Dopaminergic Neurons: Key for investigating Parkinson's disease, addiction, and other conditions involving the dopaminergic system.
Sensory Neurons: For pain research, neuropathy studies, and understanding sensory processing.
Other Specialized Neurons: Inquire about our capabilities for other specific neuronal populations.

3. Glial Cells

Astrocytes: The most abundant glial cells in the CNS, playing critical roles in neuronal support, synaptic function, blood-brain barrier maintenance, and neuroinflammation. Essential for creating more complete in vitro neural environments.
Oligodendrocytes & Microglia: Available upon request for studies on myelination, neuroinflammation, and specific disease pathologies.

4. Disease-Specific Neural Models

Patient-Derived Models: We can source iPSCs from patients with specific neurological conditions or utilize existing well-characterized patient-derived iPSC lines to create models that carry the genetic background of the disease. This includes, but is not limited to:
- Alzheimer's Disease
- Parkinson's Disease
- Amyotrophic Lateral Sclerosis (ALS)
- Spinal Muscular Atrophy (SMA)
- Autism Spectrum Disorders (ASD)
- Huntington's Disease
- Schizophrenia
Genetically Engineered Models: Utilizing CRISPR/Cas9 and other gene-editing technologies, we can introduce or correct specific mutations in iPSCs to model genetic disorders or investigate gene function.

A picture that presents Several different types of cells have been used to produce iPSCs. (OA Literature)

Fig.1 Several different types of cells have been used to produce iPSCs, including fibroblasts, neural progenitor cells, keratinocytes, melanocytes, CD34+ cells, cord blood cells and adipose stem cells.¹

Advantages of Partnering with Creative Biolabs

Choosing Creative Biolabs for your iPSC-derived neural cell needs offers significant benefits:

FAQs

What is the source of your iPSCs?
Our iPSCs are derived from ethically sourced human somatic cells (e.g., fibroblasts, blood cells) from healthy donors or patients with specific diseases, reprogrammed using non-integrating methods. We also work with established, well-characterized iPSC lines.
How are your iPSC-derived neural cells differentiated?
We employ validated, state-of-the-art differentiation protocols, often involving dual SMAD inhibition and specific growth factor cocktails, tailored to generate specific neural lineages and subtypes. Details are often based on published and optimized methodologies, similar to those characterizing morphological and functional maturation timelines.
Can I request specific neuronal subtypes not listed?
Yes, we offer custom differentiation services. Please contact us to discuss your requirements for specific neuronal or glial subtypes.
Do you offer iPSC-derived cells from patients with specific diseases?
Absolutely. We can source or generate patient-derived iPSC lines for a wide array of neurological conditions to create highly relevant disease models.
How do I get a quote for your products or services?
You can request a quote through our website or by contacting our sales team directly.

At Creative Biolabs, we understand that your research demands the highest quality tools. Our iPSC-derived neural models are more than just cells; they are meticulously crafted systems designed to bring human neurobiology to your benchtop with greater accuracy and relevance than ever before. We're not just a supplier; we see ourselves as your collaborative partner. Whether you're unraveling the complexities of a devastating neurological disorder, searching for the next breakthrough therapeutic, or pioneering new frontiers in neuroscience, our cells and our scientific team are here to support your journey. Contact us to discuss your specific research needs and discover how Creative Biolabs' iPSC-derived neural modeling services can propel your neuroscience R&D program forward.