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Neuroactive Peptide
By providing customized solutions and high-quality services, Creative Biolabs is your reliable partner. Our specialized scientist team offers tailored neuroactive peptide development and production services for your neuroscience research.
Overview of Neuroactive Peptide
What are Neuroactive Peptides?
Neuroactive peptides are endogenous protein molecules comprised of at least two amino acids and are a diverse class of neuronal signaling molecules. They are found in large vesicles on nearly all areas of the neuron, commonly the axon terminal at the synapse. Central and peripheral neurons produce a vast number of neuroactive peptides alongside enteroendocrine cells in the gastrointestinal tract and other endocrinologically active cells. These neuroactive peptides regulate physiological processes and behavior in animals. Many of these neuroactive peptides evoke excitatory or inhibitory responses in postsynaptic ion channels, yet it is still uncertain that they act as true neurotransmitters or as neuromodulators.
Until now, approximately 100 different neuroactive peptides have been identified. Among those peptides known to affect synaptic transmission are neuropeptide Y, substance P, neurotensin, galanin, cholecystokinin, somatostatin, vasoactive intestinal peptide, and opioid peptides. The recognition of biologically active peptides as neuroactive peptides produced by neurons and/or having effects on both neurons and nonneuronal cells is still relatively new and has evolved only in the past 60 years.
Roles of Neuroactive Peptides
Neuroactive peptides are released from a wide range of nerves. They exhibit characteristic patterns of localization within the peripheral nervous system (PNS) and central nervous system (CNS) and possess the ability to stimulate a range of diverse biological activities, such as the effects on neuronal excitability and activity.
- Mechanisms of peptide action include classical fast-acting neurotransmitter action on ion channels in neurons, directly resulting in changes in cell membrane potential. In addition, they can affect neuronal activity indirectly by up-or down-regulation of synaptic function, affecting cell metabolism and even, via effects on protein synthesis, regulating the growth and development of neuronal connections.
- Brain neuroactive peptides not only participate in stress physiology but may also have clinical relevance. The study of neuroactive peptides and their receptors in animal models has additionally revealed physiological and pathophysiological roles that in turn have led to the ongoing development of new drugs, through utilization predominantly of antagonist activities, becoming important and effective tools in the management of stress-related mood disorders.
Fig.1 Neuroactive peptides in gut microbiota-host interaction in the periphery.1
Services at Creative Biolabs
Many neuroactive peptides play an important role in the CNS of the brain. As a leading company in the neuroscience market, experts in Creative Biolabs possess enriched experience in the production of neuroscience research tools. We are dedicated to offering worldwide support for our customers. We have purposely built our custom production of neuroactive peptides to improve turnaround times so you can make prompt, confident decisions for neuroscience research. In addition, we also offer other neuroscience research tools for your research, including but not limited to viral vectors for neural circuitry research, antibody, neuromodulating compounds, reprogramming factors, and direct conversion factors.
Creative Biolabs is specialized in the custom development of basic neuroscience research tools. We can offer many different technical platforms for our customers and focus on ideal neuroscience tools design and development that meet all your requirements. Please contact us for more information and a detailed quote. We look forward to finding the best-fit solution for your needs.
Our team of expert scientists and researchers have extensive experience in the design, synthesis, and characterization of neuroactive peptides, and we are committed to delivering high-quality products and services to our clients. Some of the key custom services we offer include:
- Custom peptide design
- Peptide synthesis
- Peptide modification
- Peptide labeling
- Peptide characterization
- Functional assays
Overall, our neuroactive peptide custom services are designed to support and accelerate the groundbreaking research efforts of our clients in the field of neuroscience. We also offer flexibility in our services, including but not limited to:
| Services | Descriptions |
|---|---|
| Custom CNS Disease Modeling | Our platform can offer reliable custom CNS disease modeling services including but not limited to Alzheimer's disease models, Huntington's disease models, and Parkinson's disease models. |
| Neuronal Activity Monitor | Creative Biolabs has a reputation as an industry-leading provider of basic neuroscience assays. We specialize in neuroscience and have built a comprehensive technology platform. Neuronal activity monitoring service is one of the proven services offered by our platform. |
| STEMOD™ Advanced Drug Discovery | Our platform has advanced neuroscience ex vivo models, neuroscience assay techniques, and neuroscience research tools. These technologies will cover every important stage of CNS drug discovery, resulting in a one-stop shop for our customers. |
Published Data
Carlos Alberto-Silva et al. have been exploring the bioactive components of the venom of the solitary wasp. They investigated the composition of the venom of the solitary scoliid wasp Scolia decorata ventralis by a comprehensive analysis using LC-MS, synthesized two peptides and evaluated their neuroprotective properties.
They determined the sequences of the two main peptide components, α-scoliidine and β-scoliidine, by MALDI-TOF/TOF MS analysis, which were then confirmed by solid-phase synthesis. Both peptides were subjected to cell integrity testing and neuroprotection analysis using H2O2 as an inducer of oxidative stress. The results indicated that the two main peptide components were bradykinin-related peptides and that β-scoliidine exhibited effective cytoprotective effects.
Fig. 2 Neuroprotective property of α-scoliidine or β-scoliidine on mitochondrial metabolism of the PC12 cell line against H2O2-induced oxidative stress.2
Applications
We work closely with researchers to understand their specific objectives and design peptides that target specific receptors or pathways within the nervous system. Our team of experts has extensive experience in peptide chemistry and neuroscience research, allowing us to deliver high-quality peptides that are optimized for maximum activity and stability. We utilize state-of-the-art techniques and equipment to ensure the purity and quality of our peptides, guaranteeing reliable and reproducible results in research experiments.
Some of the applications of our neuroactive peptides include:
- Our peptides can be used as tools for screening and identifying novel drug candidates that target specific neuroactive pathways.
- Our peptides can be used to study the role of neuroactive peptides in various physiological and pathological processes within the nervous system.
Contact us today to learn more about how we can support your neuroscience research goals with our customized peptide services.
FAQs
Q: What types of neuroactive peptides do you provide in your services?
A: We offer a comprehensive range of neuroactive peptides, including endogenous peptides like neuropeptides, neurotransmitters, and other small signaling molecules. Our services also extend to the synthesis and customization of peptide analogs for specific research needs. Each peptide can be tailored in terms of purity, labeling, and modifications to align with your experimental objectives, ensuring precise results in neuroscience studies.
Q: How do you handle peptide labeling and conjugation for neuroimaging or tracking experiments?
A: We offer specialized labeling and conjugation options, including fluorescent dyes, biotin, or radiolabels, depending on your imaging or tracking needs. Our team ensures optimal peptide labeling efficiency while maintaining biological activity. We provide tailored solutions for different platforms like confocal microscopy, flow cytometry, or in vivo imaging, allowing you to seamlessly integrate labeled peptides into your research workflow.
Q: What kind of data or documentation will I receive with the neuroactive peptides?
A: With every peptide order, you will receive a comprehensive data package that includes a Certificate of Analysis (COA), purity reports from HPLC analysis, and mass spectrometry profiles. Additionally, we provide technical details such as peptide sequences, molecular weight, solubility guidelines, and storage conditions. This ensures you have all the necessary information for accurate experimental design and reproducibility.
Q: How do you handle batch-to-batch consistency in peptide production for long-term studies?
A: We take batch-to-batch consistency very seriously, implementing rigorous manufacturing protocols to ensure reproducibility across different production lots. Peptides are synthesized under strict quality controls, and each batch is characterized to match the original specifications. We also offer batch reservation services for long-term studies, allowing you to secure a consistent peptide supply throughout your research project.
Scientific Resources
References
- Holzer, P. Neuropeptides, microbiota, and behavior. International review of neurobiology. 2016, 131, 67-89.
- Alberto-Silva, Carlos, et al. "Novel neuroprotective peptides in the venom of the solitary scoliid wasp Scolia decorata ventralis." Journal of Venomous Animals and Toxins Including Tropical Diseases 27 (2021): e20200171.
For Research Use Only. Not For Clinical Use.