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HTT Gene-Engineered Cell Models Products

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To propel research and drug discovery for Huntington's disease (HD), a debilitating neurodegenerative disorder rooted in a mutated Huntingtin (HTT) gene, we provide a comprehensive portfolio of meticulously engineered HTT Gene-Engineered Cell Models. These advanced cellular tools are designed to faithfully reproduce the diverse genetic variations and intricate cellular pathologies characteristic of HD, offering researchers a robust platform for in-depth investigation.

Elevate your HD research endeavors. Contact us to receive a personalized quotation and explore the transformative potential of our HTT Gene-Engineered Cell Models in driving your next significant scientific breakthrough. Discover how our precisely crafted models can provide the critical insights needed to unravel the complexities of HD and pave the way for effective therapeutic interventions.

See our HTT model categories below, or click to view our Product List right now.

Featured HTT Gene-Engineered Cell Model Categories

HTT Gene-Engineered Cell Model Products offer several categories:

HTT CAG Expansion Models: Precisely engineered cell lines with varying lengths of CAG repeats in the HTT gene, mimicking the genetic heterogeneity observed in HD patients.
HTT Variant Models: Cell lines harboring specific pathogenic mutations within the HTT gene, enabling the study of their individual contributions to disease pathogenesis.
HTT Knock-out Models: Cell lines with complete disruption of the HTT gene, serving as valuable controls and tools for studying HTT protein function.
HTT Tagged Cell Lines: These are genetically modified cell lines. They have fluorescent tags. Or other markers on the endogenous HTT protein. This enables live-cell imaging. It also enables protein interaction studies. And protein localization analysis.

Features of Our HTT Gene-Engineered Cell Models

Creative Biolabs' HTT Gene-Engineered cell models stand out for several reasons:

Feature	Description
Precise Gene Editing	Engineered using advanced technologies like CRISPR-Cas9 for accurate and targeted modification of the HTT gene.
Disease Relevance	Models faithfully recapitulate key aspects of HD pathology, including mutant HTT protein aggregation, transcriptional dysregulation, and cellular dysfunction.
Cellular Diversity	Available in a variety of cell types, including neurons, astrocytes, and fibroblasts, to study the diverse cellular contributions to HD.

Advantages of Our HTT Gene-Engineered Cell Models

To highlight the benefits of our offerings, we provide a range of powerful tools. Our HTT gene-engineered cell models offer unprecedented opportunities. They are for studying Huntington's Disease (HD) and developing therapies. When you choose Creative Biolabs, you benefit from:

Accelerate Research: Our models provide a robust and reliable platform for studying HD pathogenesis, facilitating faster and more efficient research.
Improve Drug Discovery: These models enable the identification and validation of novel therapeutic targets and the screening of potential drug candidates.
Reduce Animal Use: Cell-based models offer a valuable alternative to animal models, promoting ethical and efficient research practices.
Enhance Translational Relevance: By accurately reflecting the human disease, our models increase the translational potential of research findings.
Save Time and Resources: Our ready-to-use models eliminate the need for time-consuming and complex cell line development, saving you valuable resources.

A picture presents the mHTT's pathological processes. (Makeeva, et al., 2023) (OA Literature)

Fig.1 Pathological processes triggered by mHTT.¹

HTT Mechanisms of HD

Huntington's disease (HD) is a brain disorder. It gets worse over time. An expanded CAG repeat in the HTT gene causes it. This gene change makes a bad protein. The bad protein is called mHTT. It has a very long part. This long part is made of glutamine. The normal HTT protein does important things in cells. It moves things inside nerve cells. Also, it controls how genes work. And it helps the cell's power plants. But mHTT is there, and it stops these things from working correctly.

The mutant HTT protein has diverse harmful effects. Its changed structure causes it to misfold. Then, it forms clumps. These clumps appear inside cells. They can block important cellular machinery. Also, mHTT damages mitochondria. This leads to more oxidative stress. And the cells have less energy. Furthermore, mHTT changes the activity of some genes. These genes are important for nerve cell health. One example is the BDNF gene. In addition, mHTT disrupts the transport of vital molecules in nerve cells. This further impairs how they function. Also, the expanded CAG repeat in the HTT gene can get longer in certain brain cells over time. This may contribute to the disease starting later and progressing.

FAQs

What are the applications of Creative Biolabs' HTT Gene-Engineered Cell Model Products?
Our cell models help study Huntington's Disease (HD). They help us learn how the disease works. Also, they help find new medicines. And they help make better treatments. Scientists can use them to study how the disease changes cells. They can also test if new drugs work. This helps make treatments for HD faster.
What is an isogenic cell model, and why is it important?
Isogenic cell models are valuable tools. They have the same genetic makeup as normal cells. However, they have the specific genetic alteration that causes HD. This difference is the expanded CAG repeat in the HTT gene. This similarity is crucial for research. It helps reduce other factors that could affect the results. Therefore, scientists can more clearly study the effects of the HD mutation. They can focus on how it changes cell behavior and how the disease progresses.
What is a patient-derived cell model?
Patient-derived cell models come from people with Huntington's Disease. These cells keep the person's own genes. They also keep the person's cell features. So, these models are helpful. They show how the disease is different in different people. And they can help find treatments that work best for each person.
Can the cell models be customized?
Indeed, we provide options for the customization of our cell models. This includes the introduction of specific genetic backgrounds, the integration of reporter genes for enhanced tracking, and other modifications tailored to your research objectives. We encourage you to contact us to discuss your precise experimental requirements, enabling us to adapt our cell models to optimally suit your investigations.
What related services do you offer, in addition to HTT gene-engineered cell models?
We also offer other services. One service is making custom cell lines. We use our skills in gene editing for this. This lets us create models made just for you. Another service is drug screening. We use our cell models for this. This helps test possible new medicines.

Our HTT Gene-Engineered Cell Models are designed to empower your research and accelerate the development of new therapies for Huntington's disease. With our comprehensive portfolio of high-quality cell models, you can:

Gain deeper insights into the molecular mechanisms of HD
Identify and validate novel therapeutic targets
Screen and evaluate potential drug candidates
Develop more effective treatment strategies

Are you ready to advance your Huntington's disease research? Contact us today to discuss your specific project requirements and request a tailored quotation. Our team of experienced scientists is committed to providing you with high-quality cell models and comprehensive support to facilitate the achievement of your research objectives.