Online Inquiry

Knock-Out Neural Models Products

Introduction Advantages Comprehensive KO Solutions Applications FAQs Related Product Sections Product List

Revolutionizing Neuroscience Research with Advanced Cellular Models

Creative Biolabs is at the forefront of neurobiological research, empowering scientists with advanced tools such as Knock-Out (KO) Neural Model Cells. These models are essential for gaining invaluable insights into gene function, disease mechanisms, and therapeutic development. We specialize in generating high-quality, validated KO neural cell products to accelerate your research and innovation. While the brain's complexity challenges traditional genetic modification, Creative Biolabs employs cutting-edge CRISPR/Cas9 technology to provide KO neural cell models that overcome these hurdles, offering precise tools for dissecting neuronal pathways. Contact us today to discuss your specific project requirements and learn how our tailored solutions can propel your neuroscience research forward.

You may also directly consult our comprehensive Product List for specific offerings.

Advantages of Knock-Out Neural Models

Knock-out neural models, where specific genes are inactivated, are indispensable for:

Advantages	Description
Deciphering Gene Function in Neurophysiology and Pathology	Elucidating Neuronal Processes: Clarifying gene roles in neuronal development, synaptic activity, and survival (e.g., Grin1 KO's impact on NMDA receptors). Modeling Neurological Disorders: Mimicking human neurological and psychiatric diseases, where cell-specific KOs (e.g., Act1) are effective for modeling conditions like EAE. Uncovering Novel Disease Mechanisms: Revealing new mechanisms, such as Has3 KO linking hyaluronan deficiency and reduced brain ECS to epilepsy.
Understanding Complex Biological Processes	Studying Neurogenesis and Neuronal Survival: For instance, NOS-I KO enhanced new neuron survival, indicating its inhibitory role independent of hippocampal BDNF. Dissecting Cell-Type Specific Roles: Precisely analyzing cellular contributions to brain function and disease using cell-specific KOs (e.g., for NeuN in neurons, GFAP in astrocytes).
Accelerating Therapeutic Development	Validating Therapeutic Targets: Crucially validating potential drug targets. Guiding Preclinical Research: Informing KO animal model development for complex preclinical testing based on cell model insights.

Comprehensive KO Solutions

Creative Biolabs offers a comprehensive suite of services and products related to KO neural cell models, tailored to meet the unique demands of your research.

Precise Gene Editing

We use CRISPR/Cas9 for highly efficient, precise neural gene targeting with minimal off-target effects.

Broad Cell Coverage

KO models for many neural cell types (primary, iPSC-derived, glia, NSCs, lines).

Flexible KO Strategies

Tailored constitutive, conditional, or multiple gene KOs.

Fast Turnaround

Efficient in vitro workflows for rapid project completion.

Thorough Validation

Stringent genomic, expression, and phenotypic validation for all KO models.

Expert Project Support

Our neuroscientists provide dedicated support from design to data interpretation.

Featured Applications

Applications	Description
Analyze Synaptic Mechanisms	Use KO cells for specific genes to define synaptic protein roles and analyze resulting deficits.
Model Brain Disorders	Generate in vitro KO models for genes implicated in neurodegenerative and neuroinflammatory diseases to aid therapeutic screening and study cellular pathology.
Explore Neurodevelopment	Investigate developmental gene roles in differentiation, migration, and circuit formation using KO neural stem/progenitor cells, elucidating disorder mechanisms.
Assess Glial Functions	Study glial roles in brain health and disease using specific KO lines to examine glia-neuron interactions and related pathology, including changes in the extracellular space.
Uncover Survival/Neuroprotection Pathways	Use KO cells for relevant genes to identify pathways for neuronal resilience or death, valuable for testing neuroprotective strategies.

A picture that presents the roles of Dip2b. (OA Literature)

Fig.1 The roles of Dip2b during neural differentiation.¹

FAQs

Can you create conditional knock-outs or knock-ins in neural cells?
Yes, in addition to constitutive knock-outs, we have extensive experience in developing conditional knock-out (cKO) neural cell models and knock-in (KI) models. Please inquire about these services.
Do you offer KO models for specific neurological diseases?
Yes, we can generate KO neural cells targeting genes implicated in a variety of neurological and psychiatric disorders, providing valuable tools for disease modeling.
Can you knock out non-coding genes or specific gene isoforms?
Absolutely. Our expertise extends to targeting non-coding RNAs (e.g., miRNAs, lncRNAs) and designing strategies to knock out specific gene isoforms.
What are the advantages of using your KO neural cells over siRNA/shRNA methods?
KO cells offer complete and permanent gene inactivation at the genomic level, leading to more definitive and reproducible results compared to transient or incomplete knockdown achieved by RNAi methods. This is crucial for long-term studies and understanding true loss-of-function phenotypes.
Can Creative Biolabs assist with the experimental design for using these KO cells?
While we provide the cell models, our scientific team can offer general guidance and discuss potential experimental approaches based on their expertise.

Creative Biolabs is dedicated to empowering your neuroscience research with high-quality, validated Knock-Out Neural Model Cells. Our expertise in gene editing and neural cell biology ensures you receive reliable tools to investigate the intricate workings of the nervous system.

Whether you need a model for a well-characterized neural gene or a complex, custom-designed multi-gene knock-out, our team is ready to assist. Let us help you overcome the challenges of model development so you can focus on making groundbreaking discoveries.

Discuss your project with our specialists and discover how our KO neural models can be tailored to your research objectives.