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Gene-Engineered Cell Model Products

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Introduction

Neuroscience research aims to decipher the intricacies of the nervous system. This field addresses a wide spectrum of neurological disorders. Neurodegenerative conditions like Alzheimer's and Parkinson's are included. So are developmental and psychiatric illnesses. The creation of precise and dependable models is crucial for this research. These models facilitate the investigation of disease mechanisms. They also enable the evaluation of potential therapies. Gene-engineered cell models have become vital tools. They offer the capacity to replicate disease-associated genetic alterations accurately. Scientists employ technologies such as CRISPR-Cas9. This allows the generation of cell lines harboring specific disease mutations. Consequently, more physiologically relevant studies of disease development and drug discovery are possible. These models present notable benefits over conventional cell cultures and animal models. They provide a more controlled and human-relevant system for probing neurological diseases.

Learn how our gene-engineered cell models can specifically aid your neuroscience research. We can also meet your unique project needs. Contact our expert team to explore these opportunities. We are dedicated to providing custom solutions and thorough support. Our aim is to speed up your scientific breakthroughs.

Categories of Gene-Engineered Cell Model Products

Creative Biolabs provides various gene-engineered cell model products. These are organized for different research uses:

Gene Mutated Models: Cell lines with specific gene changes. These changes can be single-point mutations. They can also be deletions or insertions. These models are very important. They help study what happens when genes have disease-causing changes. They also help create therapies. These therapies target the effects of these gene changes.
Gene Knockout Models: Cell lines in which a specific gene has been inactivated, allowing for the study of gene function and loss-of-function phenotypes.
Gene Knock-in Models: Cell lines in which a specific gene has been inserted, often with a particular mutation or reporter gene, to study gene expression, protein function, and disease mechanisms.
Gene Overexpression Models: Cell lines made to produce more of a certain gene than usual. These models are very useful. They help study what happens when there's too much of a protein. They also help to understand gain-of-function effects. Plus, they show how increased protein levels affect cells and diseases.
Tagged Cell Lines: Express proteins with tags like FLAG or HA. These tags allow efficient protein isolation. This enables detailed protein interaction studies. Cellular networks can be mapped effectively. Subcellular localization can be precisely determined. Post-translational modifications can also be characterized. These capabilities offer crucial insights. They help understand protein function and regulation.

Typical Genes in Neuroscience Research and Related Diseases

Gene Symbol	Gene Name	Associated Neurological Conditions/Research Area
APP	Amyloid Precursor Protein	Alzheimer's Disease
PSEN1	Presenilin 1	Alzheimer's Disease
PSEN2	Presenilin 2	Alzheimer's Disease
APOE	Apolipoprotein E	Alzheimer's Disease, Cardiovascular Disease
SNCA	Alpha-Synuclein	Parkinson's Disease, Lewy Body Dementia
LRRK2	Leucine-Rich Repeat Kinase 2	Parkinson's Disease
PARK2	Parkin RBR E3 Ubiquitin Ligase	Parkinson's Disease
HTT	Huntingtin	Huntington's Disease
SOD1	Superoxide Dismutase 1	Amyotrophic Lateral Sclerosis (ALS)
TDP-43	TAR DNA-Binding Protein 43	Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration
C9orf72	C9orf72	Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration
GLUT4	Glucose Transporter Type 4	Insulin Resistance, Neurological Complications of Diabetes
RNU4-2	RNA, U4 small nuclear 2	Spinal Muscular Atrophy (as part of the SMN complex)
Nurr1	Nuclear Receptor Related 1 Protein	Dopaminergic Neuron Development, Parkinson's Disease
ZfP521	Zinc Finger Protein 521	Neural Development, Neurogenesis

Fig.1 Molecular mechanism involved in the β-amyloid cascade hypothesis of Alzheimer's disease.¹

Features of Our Gene-Engineered Cell Models

Creative Biolabs' Gene-Engineered Cell Model Products offer a range of key features that make them powerful tools for biological research:

Features	Descriptions
Precise Genetic Modifications	Utilizing CRISPR-Cas9 technology, we can introduce specific and targeted changes to the cellular genome, including knockouts, knock-ins, and point mutations.
Rigorous Validation	Our cell models undergo extensive validation to ensure the accuracy of the genetic modifications.
Broad Applicability	Our gene-engineered cell models can be used in a wide range of research applications, including drug discovery, target validation, and disease modeling.

Advantages of Our Gene-Engineered Cell Models

By choosing Creative Biolabs' Gene-Engineered Cell Model Products, you can benefit from:

Enhanced Disease Modeling

Our models provide a more accurate and physiologically relevant representation of disease states compared to traditional cell culture methods.

Accelerated Research

Our customized cell models can help you accelerate your research and drug discovery efforts.

Improved Reproducibility

The precise genetic modifications and rigorous validation of our models ensure high reproducibility of experimental results.

Reliable Results

Our gene-engineered cell models provide a more controlled and reliable system for studying gene function and drug response.

FAQs

What contributes to the high reproducibility of your gene-engineered cell models?
Our cell models undergo precise genetic modifications and thorough validation. This ensures high reproducibility in experimental results. Traditional cell culture can lack consistency. Our models employ highly controlled, standardized procedures. Advanced gene editing allows precise targeting of specific genes. Extensive validation confirms accurate modifications. Genetic sequencing and functional assays are part of this. Resulting cell lines are stable and consistent. This high reproducibility is critical for reliable research. It also facilitates comparisons across diverse studies.
How do gene-engineered cell models improve the reliability of research results?
Gene-engineered cell models enhance research reliability through precise modifications and validation, ensuring high reproducibility in experiments. Traditional cell culture can show variability. Our models employ controlled, standardized procedures. Advanced gene editing precisely targets genes. Extensive validation confirms accurate modifications and stable lines. This high reproducibility is crucial for reliable findings. It also enables better comparisons across diverse studies.
Can Creative Biolabs create cell models with multiple genetic modifications?
Creative Biolabs generates cell models with multiple concurrent genetic modifications. This is key for researchers studying intricate diseases. Consider Alzheimer's, Parkinson's, or cancer. Modeling multiple mutations offers precise disease mechanism insights. Our expert team designs and executes these complex projects. We ensure accurate and viable cell models. Contact us to discuss your needs.
Are Creative Biolabs' gene-engineered cell models useful for finding new drugs and checking drug targets?
Yes, our gene-engineered cell models are widely used in drug discovery and target validation. They offer a controlled and reliable system for studying drug responses and the effects of specific genetic alterations, making them ideal tools for these applications.
What cell types can Creative Biolabs engineer?
We can work with many cell types. This includes common cell lines. We can also handle some primary cells. Please ask our experts. They can tell you if we can engineer the specific cell type you need.

Creative Biolabs delivers premier gene-engineered cell models and superior support. We accelerate your research. Achieve your goals with us. Contact our team for details and project discussion.