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LRRK2 Gene-Engineered Cell Models Products

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LRRK2, or leucine-rich repeat kinase 2, is a key protein. Researchers are studying its connection to Parkinson's disease (PD). Creative Biolabs offers a range of cell models with modified LRRK2 genes. We carefully create these models. They aim to help researchers unravel the details of PD. Ultimately, they want to advance the creation of new treatments.

Our cell models are precision-engineered to cover the complex genetic variations that exist for PD. We recognize that all research studies are individualized and that our models are designed to suit the specific needs of our customers, offering a solid platform for probing disease pathways and testing potential therapeutics. Reach out to us for an in-depth consultation to learn how our LRRK2 cell models can assist you and discuss our tailored solutions.

See our LRRK2 model categories below, or click to view our Product List right now.

Featured LRRK2 Gene-Engineered Cell Model Categories

Take a look at our LRRK2 gene-engineered cell model offerings. These are designed to give you the exact tools you need for your research:

LRRK2 Mutation Models: These models enable detailed analysis of how specific LRRK2 mutations (e.g., G2019S, R1441C) disrupt cell functions like protein folding, synaptic vesicle behavior, and mitochondrial health, revealing potential therapeutic targets.
LRRK2 Knock-Out Models: By removing LRRK2 expression, these models help determine its normal physiological function, downstream effects on cellular signaling, synaptic plasticity, and neuronal survival, and identify potential compensatory mechanisms.
LRRK2 Knock-In Models: These models express LRRK2 variants at natural levels, providing a physiologically relevant system to study subtle alterations in LRRK2 function and their long-term consequences on cellular health.
LRRK2 Tagged Cell Lines: Expressing LRRK2 with tags (e.g., GFP, FLAG), these cell lines facilitate protein localization, interaction, and dynamics studies, crucial for understanding LRRK2's role in cellular pathways and how mutations affect its behavior.

Features of Our LRRK2 Gene-Engineered Cell Models

Creative Biolabs' LRRK2 Gene-Engineered cell models stand out for several reasons:

Feature	Description
Precise Genetic Modification	We employ advanced gene-editing technologies, such as CRISPR-Cas9, to introduce specific LRRK2 alterations with high accuracy, minimizing off-target effects.
Disease Relevance	Our models faithfully recapitulate key aspects of LRRK2-linked Parkinson's disease, closely mimicking the cellular and molecular changes associated with the disease.
Versatility	A broad spectrum of models, including knockout, knock-in, and overexpression, is available to suit diverse research objectives and experimental designs.

Advantages of Our LRRK2 Gene-Engineered Cell Models

When you choose Creative Biolabs, you benefit from:

Unparalleled Accuracy: Our models provide a reliable and physiologically relevant system for your studies. Beyond mere mutational introduction, our methodology rigorously ensures genetic modification fidelity, coupled with the veridical recapitulation of the disease phenotype at the cellular level. This exacting commitment to precision underpins the robustness of subsequent investigations, thereby fostering the generation of impactful and translationally relevant outcomes.
Customization Options: We understand that research needs vary. Bespoke cellular model generation, precisely tailored to investigator-defined specifications, constitutes a core capability. Ranging from the introduction of singular, locus-specific mutations within defined cell lineages to the engineering of intricate models incorporating supplementary genetic modifications, our team facilitates the design and derivation of customized cellular systems. This inherent adaptability empowers the targeted interrogation of discrete research inquiries with optimal experimental platforms.
Expert Support: Our team of seasoned scientists is here to provide guidance and support throughout your research journey. Comprehensive support, spanning initial consultation through experimental paradigm design and subsequent data interpretation, is provided to facilitate investigative success. Our cadre of experts possesses substantive experience in gene editing technologies, cellular model system development, and Parkinson's disease research, maintaining a dedicated focus on the attainment of your specific research objectives.

A picture presents Cell biological processes impacted by LRRK2. (Berwick, et al., 2023) (OA Literature)

Fig.1 Cell biological processes impacted by LRRK2.¹

LRRK2 Mechanisms in PD

LRRK2 is a protein with a complex structure. It contains several domains. Among them are kinase and GTPase domains. Scientists think it's involved in various cellular activities. When it doesn't work correctly, it might contribute to Parkinson's disease.

Here's a glimpse into the key mechanisms:

Kinase Activity: LRRK2 possesses kinase activity, and certain PD-linked mutations enhance this activity, potentially leading to toxic downstream effects.
Protein Interactions: LRRK2 interacts with a myriad of other proteins, and these interactions may be disrupted in PD.
Cellular Processes: LRRK2 is thought to be involved in processes such as vesicle trafficking, autophagy, and mitochondrial function, all of which are affected in PD.

FAQs

What are the applications of your LRRK2 gene-engineered cell models?
Our cell models are powerful tools. They help us study Parkinson's disease (PD). Scientists can investigate LRRK2 mutations with them. These models show how mutations contribute to the disease. Researchers can screen potential drug targets. This helps in finding new treatments. They also aid in developing new treatment strategies. These models are valuable for PD research.
How do you ensure the accuracy of your LRRK2 gene-engineered cell models?
We use advanced gene-editing technologies. These technologies ensure precise modification of the LRRK2 gene. Our models undergo rigorous validation. This validation confirms they accurately mimic LRRK2-linked Parkinson's disease.
How do tagged LRRK2 cell lines facilitate protein studies?
Adding fluorescent tags to LRRK2 is possible. We can also use affinity tags. This allows the study of protein localization. It helps us understand protein interactions as well. We can also observe protein dynamics. These tags are very useful tools.
What if you need a specific LRRK2 mutation model not listed?
No problem. We specialize in creating custom cell models. Just contact us with what you need. We will do our best to help you.
How can I order LRRK2 gene-engineered cell models?
To order LRRK2 gene-engineered cell models, you have a couple of options. You can submit an online inquiry. Or, you can reach out to us by email.
Can I use your LRRK2 cell models for long-term culture experiments?
Yes, they are also viable for long-term culture. This allows chronic exposure studies. It also enables modeling of age-related effects. However, following our recommended culture protocols is essential. This maintains cell health. It also preserves the cell phenotype.

Our LRRK2 gene-engineered cell models are powerful tools for elucidating the role of LRRK2 in Parkinson's disease and for the development of effective therapies. We are committed to providing you with the highest quality models and support to accelerate your research. Contact us today to explore how our LRRK2 cell models can be tailored to your specific research goals.