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PARK2 Gene-Engineered Cell Models Products

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The PARK2-encoded E3 ubiquitin ligase orchestrates mitochondrial quality control (via FUNDC1-mediated mitophagy), proteostasis (20S proteasome assembly), and cell cycle regulation (p21 degradation). Dysfunctional PARK2 variants drive pathologies spanning early-onset Parkinson's (dopaminergic mitophagy failure) to lung adenocarcinoma (p53/MDM2 dysregulation). Our isogenic models—CRISPR-edited KO, OE, and disease-associated mutants in iPSC-derived neurons/astrocytes—enable mechanistic studies of Lewy body aggregation (phase-separated mimetics), ferroptosis susceptibility, and context-dependent oncogenic signaling. Integrated biosensors (mt-Keima for mitophagy flux) and high-content screening platforms support targeted therapeutic development. To explore tailored PARK2 models for your neurodegeneration or cancer research, contact our neuroscience team for collaborative solutions.

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Featured PARK2 Gene-Engineered Cell Model Categories

Explore our diverse selection of PARK2 gene-engineered cell models, tailored to meet a wide range of research needs. Each category is designed to provide you with specific tools to investigate the multifaceted roles of the PARK2 gene in Parkinson's disease.

PARK2 Mutation Models: Homozygous (C441R) and compound heterozygous (R275W/A227P) variants model autosomal recessive Parkinsonism, recapitulating loss-of-function variants that destabilize parkin's ubiquitin-like (UBL) domain. These systems enable investigations into: (i) conformational destabilization of Parkin's RING0 domain under oxidative stress; (ii) defective substrate recognition (e.g., MFN1 ubiquitination failure); (iii) compensatory ubiquitinome rewiring via UCHL1 overexpression.
PARK2 Knock-Out Models: In these cell lines, the PARK2 gene has been completely inactivated. By silencing PARK2 entirely, researchers can explore the downstream consequences of its absence. This is particularly relevant for understanding disease mechanisms, especially in cases where PARK2 normally acts as a tumor suppressor or provides cellular protection. These models allow us to rigorously investigate how the complete lack of PARK2 impacts various cellular activities, signaling pathways, and responses to different stimuli.
PARK2 Knock-In Models: These cell lines are engineered to carry specific insertions within the PARK2 gene. Instead of just adding genes, scientists precisely insert things like tags to track proteins, reporter genes to monitor PARK2 expression, or specific DNA sequences.
PARK2 Overexpression Cell Models: In these cell lines, the PARK2 gene is engineered to be overexpressed, meaning it produces significantly higher levels of the Parkin protein. These models are valuable for studying the effects of increased Parkin activity, which can provide insights into its normal cellular functions and potential therapeutic applications.
PARK2 Tagged Cell Lines: PARK2-tagged cell lines express Parkin protein with an extra tag. Common tags include GFP, FLAG, or HA. This modification helps scientists see the Parkin protein. It also allows them to isolate and study it. They can also study how Parkin interacts with other proteins in the cell. These cell lines have several uses. Scientists can track where Parkin is located. They can identify proteins that bind to Parkin. They can study how the Parkin protein moves and changes. Finally, they can purify groups of Parkin proteins.

Features of Our PARK2 Gene-Engineered Cell Models

Creative Biolabs' PARK2 Gene-Engineered cell models stand out for several reasons:

Feature	Description
Precise Genetic Modification	We use advanced gene-editing technologies, like CRISPR-Cas9, to introduce specific PARK2 alterations with high accuracy, minimizing off-target effects.
Disease Relevance	Our models faithfully replicate key aspects of PARK2-linked Parkinson's disease, closely mimicking the cellular and molecular changes associated with the disease.
Versatility	We offer a broad spectrum of models, including knockout, knock-in, and overexpression, to suit diverse research objectives and experimental designs.

Advantages of Our PARK2 Gene-Engineered Cell Models

When you choose Creative Biolabs, you benefit from:

Accurate Disease Modeling: When it comes to really getting disease modeling right, our PARK2 gene-edited cell models are made with incredible care to closely mimic the genetic tweaks that cause specific illnesses. This accuracy is a big deal for researchers trying to understand complicated diseases like Parkinson's, where even tiny genetic changes can have a huge impact on how cells behave. So, when you work with our models, you can be sure that your studies are built on a really relevant and biologically spot-on picture of the disease.
Consistent Results: We totally get how annoying it is when cell lines act all wonky and give you different results all the time. That's why we go all out with quality control at Creative Biolabs to make sure our PARK2 gene-edited cell lines give you really consistent results every time you run your experiments. This reliability comes from the fact that our cell lines are clonal, meaning every single cell has the exact same, confirmed genetic change. This gets rid of a lot of the unpredictable stuff and makes your data way more trustworthy.
Expert Support: It's not just about the good stuff we make. At Creative Biolabs, we've also got your back with really helpful expert support for your research. Our team is packed with Ph.D. scientists who really know their stuff when it comes to PARK2 gene editing and how it's used. Seriously, we're here to answer any questions you've got, help you figure out your experiments, and even make sense of your results. We're all about making sure you get the best possible results in your research – we're in this with you!

A picture presents the function of parkin and PARK2-related mutations. (OA Literature)

Fig.1 The function of parkin and PARK2-related mutations.¹

PARK2 Mechanisms of PD and Other Related Diseases

Problems in the PARK2 gene are a main cause of autosomal recessive Parkinson's disease (PD). Parkin must work correctly for mitophagy. Mitophagy is a key process in cells. It removes damaged mitochondria selectively. When PARK2 does not work, this quality control fails. This leads to a buildup of bad mitochondria. Neurons then become damaged. This contributes to how PD develops. While PARK2 is mainly linked to PD, new research suggests more. It may play a role in other brain diseases. It seems to affect mitochondrial health. It also influences protein breakdown pathways. Elucidating the precise mechanistic underpinnings of its contribution to these related disorders remains an active and evolving domain of scientific inquiry.

FAQs

What customization services do you offer?
Our services offer many custom modifications. These modifications meet specific research needs. We can precisely introduce defined genetic alterations. We can also integrate reporter gene cassettes. Furthermore, we can derive cellular models in specific genetic contexts. These are just some of our capabilities. We aim to support your unique research goals.
What if I need a specific PARK2 mutation model that isn't listed?
No problem. We specialize in creating custom cell models. Please contact us with your requirements, and we will do our best to assist you.
What support is available for experimental design?
Our neurobiology team provides free consultation on model selection, compound dosing strategies, and endpoint assay optimization.
Can your cell models be used for drug screening?
Absolutely! Our PARK2 gene-edited cell models are ideal for drug screening, target validation, and preclinical studies. They provide a reliable platform to study the effects of potential therapeutic compounds. Please inquire about our specific cell lines and how they can be tailored for your drug discovery projects.
How can I order PARK2 Gene-Engineered cell models?
You can order PARK2 gene-engineered cell models by submitting an online inquiry or contacting us via email.
What are the potential biosafety concerns when using gene-edited cell lines?
Working with gene-edited cell lines requires careful attention to biosafety. It is crucial to protect yourself and your colleagues. We advise you to consult your institution's biosafety regulations. You should also follow their best practices. Generally, this involves working in a specific lab area. You must use personal protective equipment. Proper waste disposal procedures are also necessary. Creative Biolabs provides detailed safety information with all our cell lines. Our team is available to answer your biosafety questions. We want to ensure your safety and the integrity of your research.

At Creative Biolabs, we are dedicated to providing you with the highest quality PARK2 gene-engineered cell models and services to accelerate your research. Reach out to us today via email at info@creative-biolabs.com or submit an online inquiry to learn more about how our PARK2 gene-engineered cell model products can advance your studies.