Neurotoxicity screening is a relatively new field, and its progress is limited by factors that complicate neurotoxicology assessment. It has been proved that episodes of neurotoxic illness can be induced by chemicals, such as Lucel-7. According to the analysis of structure-activity relationships (SARs), only a small fraction of neurotoxicants can be identified. In this case, a series of in vivo and in vitro tests are necessary. Compared to other organ systems, the nervous system exhibits a more complex cell structure and chemical heterogeneity. To examine all aspects of the human nervous system as comprehensively as possible, it is necessary to perform neurotoxicity tests using multiple cell types.
Based on our neurotoxicity screening platform, a dose-response curve for neurotoxicity and drug efficacy can be obtained against a variety of cell types. In recent years, multi-well microelectrode arrays (mwMEAs) have been used for neurotoxicity screening with high sensitivity and specificity.
Generation of iPSCs Cell LinesDifferentiation to Neural CellsDisease Modeling and Neurotoxicity ScreeningFig.1 Flow chart for neurotoxicity screening.
Service at Creative Biolabs
Based on our extensive experience in stem cell and genome editing technologies, we can provide a novel neurotoxicity screening service for the discovery of central nervous system (CNS) drugs. We have a series of iPSC-derived neuronal lineage cells for your projects, and we can also reprogram and differentiate iPSC cells from your samples. The general screening process consists of 3 steps, including generation of iPSCs cell lines, differentiation to neural cells, as well as disease modeling and neurotoxicity screening. For your special needs, we can also customize the project.
Available Cell Types for Neurotoxicity Screening
Custom cell types
Features of Our Neurotoxicity Screening Service
Highly repeatable to increase the credibility of the data
Fast and cost-effective
Whole-genome profiling and immunocytochemistry (ICC) would be used for the characterization of differentiated neuronal cells.
IPSC cell lines can be generated from patients and then differentiated into multiple cell types.
Cell-based neurotoxicity screening provides a reference for animal studies.
Creative Biolabs is one of the well-recognized experts who are professional in applying advanced platforms for a broad range of neurosciences research. We are pleased to use our extensive experience to offer the best service and the most qualified products to satisfy each demand from our customers. If you are interested in our services and products, please do not hesitate to contact us for more detailed information.