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Immortalized Neural Models Products

Critical Need Applications Portfolio Advantages FAQs Related Product Sections Product List

Neuroscience research encounters challenges including the finite lifespan and heterogeneity of primary neural cells, complexities in sourcing specific neuronal subtypes, and the economic and ethical issues associated with animal models. Creative Biolabs provides meticulously developed and thoroughly characterized immortalized neural models, offering stable, reproducible, and scalable solutions. These cell lines accelerate neurobiological investigations, facilitate in-depth exploration of intricate neural pathways and disease mechanisms, and support confident screening of potential therapeutic compounds.

Contact our specialists to discuss your specific research needs and explore our comprehensive immortalized neural model portfolio. Discover how these advanced tools can significantly support your research breakthroughs.

You may also directly consult our comprehensive Product List for specific offerings.

The Critical Need for Advanced Neural Models

The profound complexity of the human nervous system presents formidable challenges to scientific inquiry. Its dysfunction underpins a diverse spectrum of neurological disorders, including neurodegenerative conditions such as Alzheimer's and Parkinson's diseases, neurodevelopmental anomalies, psychiatric illnesses, and debilitating chronic pain syndromes, which collectively impose a staggering global health burden. Elucidating the fundamental pathomechanisms of these conditions and advancing effective therapeutic interventions are critically contingent upon developing and applying in vitro models that faithfully recapitulate salient features of human neurophysiology and pathophysiology.

While primary neuronal cultures have been instrumental, their practical application is often hampered by:

Immortalized neural cell lines offer a compelling solution to these challenges, providing a continuous and consistent supply of cells that retain key characteristics of their primary counterparts.

Applications: Driving Innovation Across Neuroscience Domains

Creative Biolabs' immortalized neural models are versatile tools that can be applied to a multitude of research areas:

Neurodegenerative Disease Modeling:

Study the molecular and cellular mechanisms of Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis (ALS), and other neurodegenerative conditions. Investigate protein aggregation, oxidative stress, mitochondrial dysfunction, and neuroinflammation in disease-relevant cell types.

Neurodevelopmental Research:

Explore the processes of neurogenesis, neuronal migration, differentiation, synaptogenesis, and myelination using our NSC/NPC lines and specific neuronal/glial subtypes.

Drug Discovery and Development:
- High-Throughput Screening (HTS): Identify novel therapeutic compounds for neurological and psychiatric disorders.
- Efficacy Testing: Evaluate the neuroprotective, neuroregenerative, or modulatory effects of drug candidates.
- Neurotoxicity Assessment: Screen compounds for potential adverse effects on the nervous system, crucial for drug safety profiling.
- Pharmacology Studies: Characterize drug-receptor interactions and downstream signaling pathways.

Pain Research and Analgesic Development:

Utilize our immortalized DRG neuron models, which express a repertoire of ion channels (e.g., TRPV1, Nav1.7, Nav1.8) and receptors involved in nociception, to screen for novel analgesics and investigate mechanisms of acute and chronic pain.

Neuroinflammation and Neuroimmunology:

Employ our immortalized microglia and astrocyte lines to study inflammatory responses, cytokine release, and the role of glial cells in CNS health and disease.

Channelopathy Research:

Investigate the function and modulation of specific ion channels (e.g., sodium, potassium, calcium, TRP channels) implicated in neurological disorders, using cell lines with defined channel expression profiles.

Mechanistic Studies of Neuronal Function:

Delve into fundamental aspects of neurobiology, including synaptic transmission, neuronal excitability, intracellular signaling, and gene regulation.

Diverse and Expanding Portfolio

We offer a wide range of immortalized neural cell models, catering to various research needs, including but not limited to:

Immortalized Neural Stem/Progenitor Cells (NSCs/NPCs): Capable of self-renewal and differentiation into neurons, astrocytes, and oligodendrocytes. Ideal for developmental neurobiology, neurogenesis studies, and regenerative medicine research. These lines often express key progenitor markers like Sox2 and Nestin, and can be induced to express mature neuronal markers like βIII-tubulin and MAP2, or glial markers like GFAP and O4.
Immortalized Neurons:
- Central Nervous System (CNS) Neurons: Including cortical, hippocampal, dopaminergic, GABAergic, and hypothalamic neurons, each characterized for relevant neurotransmitter profiles and receptors. Our hypothalamic lines, for instance, mirror the approach of generating panels with differential expression of neuropeptides and hormone receptors, crucial for neuroendocrine studies.
- Peripheral Nervous System (PNS) Neurons: Featuring sensory neurons like Dorsal Root Ganglion (DRG)-derived lines (e.g., nociceptors, mechanoreceptors) which express critical pain-related targets such as TRPV1, TRPA1, Nav1.7, Nav1.8, CGRP, and Substance P. These are invaluable for pain research and analgesic drug development.
Immortalized Glial Cells:
- Astrocytes: Essential for neuronal support, blood-brain barrier modeling, and neuroinflammation studies.
- Microglia: The resident immune cells of the CNS, critical for research into neuroinflammation, neurodegenerative diseases, and immune responses in the brain.
- Oligodendrocytes & Schwann Cells: Myelinating cells of the CNS and PNS, respectively, vital for studies on myelination, demyelinating diseases (e.g., Multiple Sclerosis), and nerve repair.

A picture that presents two strategies of cellular product acquisition and application for practical purposes. (OA Literature)

Fig.1 Schematic representation of two strategies of cellular product acquisition and application for practical purposes: use of primary cells and use of immortalized cells.¹

Key Advantages of Utilizing Immortalized Neural Cell Models

Transitioning to immortalized neural cell models offers a multitude of strategic benefits for neuroscience research, directly addressing the limitations inherent in primary cultures:

FAQs

How are your neural cell lines immortalized?
We employ various established and cutting-edge techniques, including the introduction of viral oncogenes (e.g., SV40 Large T antigen), human telomerase reverse transcriptase (hTERT), or other specific genetic modifications, depending on the cell type and desired characteristics.
Are these cell lines a good substitute for primary neural cells?
While primary cells have their place, immortalized lines offer significant advantages in terms of reproducibility, scalability, and ease of use. They serve as excellent, consistent models for many research applications, particularly for initial screenings, mechanistic studies, and when large cell numbers are required.
Can these immortalized cells still differentiate?
Many of our immortalized neural stem cell lines and some progenitor lines retain the capacity to differentiate into more mature neural cell types under appropriate culture conditions. Specific differentiation protocols are often available or can be developed.
Do you offer cell lines from different species?
Yes, our catalog includes immortalized neural cell lines derived from various species, including human, mouse, and rat, to suit diverse research models.
Can I genetically modify these cell lines further?
Yes, many of our immortalized cell lines can be further genetically modified (e.g., using CRISPR/Cas9, viral vectors) for specific research purposes.

Creative Biolabs is dedicated to providing the neuroscience community with high-quality, reliable immortalized neural cell models. Our products are designed to streamline your research, enhance reproducibility, and help you achieve your scientific goals faster.

Discover the ideal neural model for your project. Browse our catalog or contact us today to discuss your specific needs with our scientific team and request a quote.