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PSEN2 Gene-Engineered Cell Models Products

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The PSEN2 (Presenilin-2) gene is a key contributor to neurodegenerative conditions like Alzheimer's disease. At Creative Biolabs, we've developed specialized cell models that precisely mimic disease-linked PSEN2 mutations. These tools empower scientists to investigate Alzheimer's biological pathways, evaluate potential drug compounds, and test treatment strategies - essential capabilities for academic labs and biopharmaceutical teams pursuing breakthroughs in dementia-related research. Unlock the potential of PSEN2 research with our cutting-edge cell models. Contact us now for pricing, customization options, or to request a product datasheet. View our PSEN2 model categories below or click to access our product list immediately.

Featured PSEN2 Gene-Engineered Cell Model Categories

PSEN2 Mutation Models: These models enable researchers to investigate the effects of specific PSEN2 mutations on key cellular processes, including amyloid processing, tau pathology, and neuronal function. For example, models incorporating mutations such as PSEN2 N141Y, PSEN2 Pro123Leu, and PSEN2 His169Asn are available to study their distinct effects on disease progression.
PSEN2 Knock-Out Models: By abrogating PSEN2 protein expression, these models help elucidate the normal physiological function of PSEN2 and the downstream consequences of its loss.
PSEN2 Knock-In Models: These models allow for the precise introduction of specific PSEN2 variants, providing a physiologically relevant system for studying subtle alterations in PSEN2 function.
PSEN2 Tagged Cell Lines: Expressing PSEN2 with various tags (e.g., GFP, FLAG) facilitates a multitude of experimental approaches, including protein localization studies, interaction analyses, and biochemical assays.

A picture presents Mutated PSEN2 residues. (OA Literature)

Fig.1 Mutated PSEN2 residues identified in the Asian countries are shown in different colors.¹

Features of Our PSEN2 Gene-Engineered Cell Models

Creative Biolabs' PSEN2 gene-engineered cell models offer a range of key features that make them powerful tools for Alzheimer's disease research:

Features	Descriptions
Precise disease modeling	Our cell models precisely replicate specific PSEN2 mutations and their effects on Alzheimer's disease, enabling accurate study of disease mechanisms.
Tools for targeted drug discovery	Our models facilitate drug screening to assess the efficacy of compounds in modulating PSEN2 processing and reducing toxic amyloid-beta peptide production.
Mechanistic insights	Our PSEN2 gene-engineered cell models enable the dissection of how PSEN2 mutations contribute to Alzheimer's disease by studying their effects on cellular function, signaling pathways, and gene expression.

Advantages of Our PSEN2 Gene-Engineered Cell Models

Creative Biolabs' PSEN2 cell models offer more relevant insights for Alzheimer's disease treatment with enhanced precision, accuracy, and clinical applicability.

Compared to traditional models, our gene-engineered cell models offer superior precision and accuracy.
Researchers can leverage the flexibility of our models to investigate a wide range of PSEN2 variants and their combinations.
Our models possess a high degree of translational relevance, as they are generated in human cell systems and undergo rigorous validation.

Our models are compatible with advanced imaging techniques and enable researchers to visualize dynamic processes and protein interactions with precision.

We develop cell models for efficient high-throughput screening (HTS) and offer custom model generation to design cell models tailored to your specific research objectives.

PSEN2 Mechanisms in AD and Other Related Diseases

It looks like PSEN2 is a real troublemaker when it comes to Alzheimer's disease (AD) and other diseases that mess with your brain. You see, PSEN2 is part of this enzyme team called gamma-secretase. This team's job is to chop up a protein called amyloid precursor protein (APP), and when it does, it creates these little bits called amyloid-beta (Aβ) peptides. One of these, Aβ42, is particularly sticky and loves to clump together.

Now, when there are glitches (mutations) in the PSEN2 gene, it can throw off how well this gamma-secretase team works. Often, this leads to making way too much of that sticky Aβ42. This extra Aβ42 then gathers into these amyloid plaques in the brain – and these plaques are a telltale sign of AD.

But PSEN2's involvement isn't just about making Aβ. It seems to have its fingers in other processes that go wrong in AD, as well as in other diseases. For example:

Making Amyloid: PSEN2 is key in how APP gets cut up and how those Aβ peptides, especially the nasty Aβ42 kind, are made. If PSEN2 has a mutation, it can mess with the balance, leading to more Aβ42 sticking around. This whole process is a big deal in how AD develops.
Brain Cell Communication Breakdown: When Aβ42 builds up, it messes with how brain cells (neurons) talk to each other. This leads to synaptic dysfunction, which is likely why people with AD start having problems with thinking and memory early on. PSEN2 mutations might directly or indirectly affect the stuff brain cells need to communicate, making this breakdown even worse.
Tau Protein Going Haywire: PSEN2 mutations are also linked to problems with another protein in the brain called tau. It can cause tau to get all tangled up (hyperphosphorylation and aggregation), which is another hallmark of AD.
Brain Inflammation: Besides its role in AD, PSEN2 might also contribute to inflammation in the brain. This neuroinflammation is a common problem in lots of other brain diseases too.
Powerhouse Problems in Cells: Mutations in PSEN2 can also hurt the mitochondria – the little powerhouses inside our cells. This means less energy gets made, there's more damaging stuff (oxidative stress), and cells can even die off (apoptosis). You see this kind of mitochondrial trouble not just in AD, but also in other conditions like Parkinson's.

To really figure out how PSEN2 and these mutations cause all this trouble in AD and other related diseases is super important. If we can understand that better, we might be able to come up with some good ways to treat these conditions.

FAQs

What PSEN2 mutations are available in Creative Biolabs' cell models?
Creative Biolabs can generate cell models with a wide range of PSEN2 mutations. Contact us to discuss your specific mutation of interest.
What cell types can be used for Creative Biolabs' PSEN2 cell models?
We offer cell models in various cell types, including neuronal cell lines and iPSC-derived neurons. Reach out to our team to inquire about the availability of specific cell types.
Are Creative Biolabs' PSEN2 cell models isogenic?
We can generate isogenic cell models, where the only difference between the control and mutant cell lines is the PSEN2 mutation. Contact us for more information on isogenic cell model generation.
How are Creative Biolabs' PSEN2 cell models validated?
Our cell models undergo rigorous validation, including Sanger sequencing, Western blotting, and functional assays. Inquire now to request detailed validation data.
Can Creative Biolabs develop custom PSEN2 gene-engineered cell models?
Yes, Creative Biolabs specializes in developing custom gene-engineered cell models tailored to your specific research needs. Contact us to discuss your custom cell model requirements.
Beyond their well-established link to early-onset Alzheimer's disease, what other conditions have been associated with PSEN2 mutations?
While PSEN2 mutations are primarily recognized for their involvement in early-onset Alzheimer's, research has also implicated them in a broader spectrum of neurodegenerative disorders. These include frontotemporal dementia and dementia with Lewy bodies. Furthermore, some studies have suggested potential connections to other diseases, such as Parkinson's disease and specific forms of cancer.

PSEN2 Gene-Engineered Cell Model Products provide a powerful platform for elucidating the role of PSEN2 mutations in Alzheimer's disease. Our expertise in gene editing and cell line engineering ensures the delivery of high-quality, reliable cell models to accelerate your research. Contact Our Team for More Information and to Discuss Your Project.