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Overexpression Neural Models Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Overexpression neural model cell products are vital tools in neuroscience, enabling researchers to study the specific roles of genes in neuronal function and disease. By increasing the expression of a particular gene, scientists can investigate its impact on cellular pathways, model gain-of-function mutations observed in diseases like Parkinson's (e.g., α-synuclein) or ALS (e.g., SOD1 mutants), or explore the therapeutic potential of protective factors (e.g., Gpx4 against ferroptosis, Prok2 in injury). Studies have shown that such models effectively recapitulate key aspects of neurological disorders and neuroprotective mechanisms, providing valuable insights and platforms for drug discovery. Creative Biolabs' Overexpression Neural Model Cell Products help you gain deeper insights into neurodegenerative mechanisms, validate novel therapeutic targets, and accelerate your neuroscience research through advanced gene-editing and cell culture technologies to deliver highly characterized and functionally validated neural cell models with specific gene overexpression. Contact our expert team to discuss your experimental needs and learn how our cell models, whether stock or custom, can be integrated into your studies to accelerate discovery and help you achieve your research goals with greater efficiency.

You may also directly consult our comprehensive Product List for specific offerings.

Types of Overexpression Neural Models We Offer

Creative Biolabs offers an extensive portfolio of expertly generated and rigorously validated overexpression neural model cell products. Leveraging state-of-the-art gene-editing and viral vector technologies (including lentiviral and AAV systems, ensuring cell-type specificity as highlighted in the α-synuclein microglial model by Bido et al.), we provide researchers with reliable and reproducible tools tailored to their specific research needs.

Our Offerings Include (but are not limited to):

Types	Description
Disease-Specific Pathway Models	Cell lines engineered to overexpress genes implicated in neurological disorders (e.g., mutant SOD1 for ALS, α-synuclein for Parkinson's). These models facilitate an in-depth study of disease-relevant dysfunctions like protein aggregation, oxidative stress, or ferroptosis.
Protective Factor Overexpression Models	Models overexpressing neuroprotective genes (e.g., Gpx4 against ferroptosis, Prok2 for injury recovery). These are key for identifying and validating therapies that enhance endogenous protective mechanisms.
Signaling & Regulatory Molecule Models	Cell lines overexpressing key signaling molecules, transcription factors, or regulatory RNAs (e.g., miR-124). These tools clarify the impact of altered gene expression on neuronal development, plasticity, neuroinflammation, and survival.
Custom-Target Overexpression Models	We specialize in developing models to overexpress any gene of interest in your chosen neural cell background, offering tailored solutions for unique research questions.
HEK293-Based Neural Models	We also offer HEK293 cell lines engineered to overexpress key neuron-specific or neurology-relevant genes. These models provide a highly transfectable and scalable system for studying specific protein functions, pathway interactions, or for initial compound screening before moving to more complex primary or iPSC-derived neural cells.

Advantages for Your Neurological Research

Leveraging Creative Biolabs' Overexpression Neural Models offers distinct advantages:

Accelerate Disease Modeling

Gain deeper insights into neurological disorder mechanisms by studying overexpression effects on cellular phenotypes (e.g., protein aggregation, oxidative stress, ferroptosis, neuroinflammation).

Identify and Validate Novel Targets

Efficiently assess functional consequences of overexpressing potential therapeutic or disease-associated genes.

Streamline Drug Discovery

Use consistent platforms for high-throughput screening of compounds modulating disease pathways.

Enhance Reproducibility

Standardized, quality-controlled models ensure more reliable experimental outcomes.

Save Time and Resources

Bypass lengthy in-house model development with our ready-to-use and custom solutions.

Access Scientific Expertise

Benefit from our neuroscientists' support for model selection and experimental design.

Applications of Overexpression Neural Model Cell Products

Our overexpression neural cell models are versatile tools for diverse neuroscience applications, enabling in-depth research across various areas:

Applications	Description
Neurodegenerative Disease Research	Model diseases like ALS (e.g., SOD1, miR-124 overexpression), Parkinson's disease (e.g., α-synuclein overexpression), and Alzheimer's disease by overexpressing key pathological proteins. Investigate disease mechanisms such as protein aggregation, oxidative stress, and ferroptosis (e.g., involving Gpx4).
Neuroinflammation Studies	Understand the role of specific genes in microglia or astrocytes activation and function.
Traumatic Brain Injury (TBI) Research	Explore the effects of overexpressing specific proteins (e.g., Prok2) in TBI models.
Drug Discovery and Development	Serve as robust platforms for drug screening and identifying novel therapeutic targets.
Signaling Pathway Dissection	Elucidate complex signaling pathways involved in neuronal health and disease.
Neuroprotective Strategy Evaluation	Assess the efficacy of potential neuroprotective strategies or gene therapy approaches.
Neurodevelopmental Disorder Research	Aid in studying neurodevelopmental disorders and the impact of genetic variations on neuronal function.

A picture that presents current iPSC-based approaches for reproducing

Fig.1 A graphical schematic of current iPSC-based approaches for reproducing "aging" in vitro.¹

FAQs

Why use an overexpression model in neuroscience?
To understand gene function, especially if increased activity is disease-linked, aiding in mechanism study, target ID, and therapy testing (e.g., α-synuclein for Parkinson's).
What neural cell types do you offer?
Motor/cortical/dopaminergic neurons, microglia, astrocytes, lines like PC12, NSC-34, and iPSC-derived cells.
Can I request a gene not in your catalog?
Yes, custom model development for your specific gene and cell type is a core service.
Can I use these for drug screening?
Yes, their consistent expression makes them excellent for screening compound libraries.
What species are the models from?
Primarily human (including iPSC-derived) and rodent (mouse, rat); others by custom request

The journey to understanding and treating neurological disorders is complex. Creative Biolabs is dedicated to providing the scientific community with superior research tools that can simplify this journey. Our Overexpression Neural Model Cell Products offer a powerful, targeted approach to investigate disease mechanisms, identify novel therapeutic targets, and screen potential drug candidates.

By mimicking key aspects of human neuropathology, from the detrimental effects of mutant SOD1 or α-synuclein accumulation to the protective roles of Gpx4 and Prok2, and the regulatory intricacies of miR-124, our models provide a critical bridge between basic research and clinical translation.

Partner with Creative Biolabs today to access robust, validated overexpression neural models and accelerate your path to discovery. Contact us to discuss your specific research needs and learn how our expertise can contribute to your success.