Glial Progenitors

Overview Our Service Applications FAQs Scientific Resources Related Services

Over the years, Creative Biolabs has been accumulated further experience in STEMOD™ neuroscience ex vivo models. We are fully dedicated to providing a full range of research services, such as the astrocyte differentiation service for our global customers.

Glial Progenitors

Glial cells are derived from stem cells that mature through many stages of development to generate differentiated astrocytes and oligodendrocytes. Glial cells can be formed from the induced neuroectoderm, and the initially formed glial precursors generated in the ventricular or subventricular zone migrate to their final destinations using cues similar to those used by neurons. Glial progenitor cells (GPCs) are present throughout the parenchyma of the central nervous system (CNS) in the brain and arise from neural stem cells of the ventricular subependymal. GPCs numerically represent an extremely large cell pool. GPCs likely divide at a slow rate in-situ to provide cellular replacement of glial populations throughout life, including astrocytes, microglial phenotypes, and oligodendrocytes.

Localization of neural stem cells and the widespread localization of glial progenitors.

Role in the Nervous System

Glial cells and their progenitors play multiple roles helping to alleviate neurological defects after brain injury, not the least by promoting axonal and neuronal function and fostering neuronal survival. GPCs, as the source of oligodendrocytes, are responsible for remyelination in the demyelinated adult CNS. Proliferating glial cells within the injury site provide a local source of cells for repair, including replacing neurons. This precursor cell can be surviving in the damaged environment and migrate into the lesioned site to participate in the remyelination of damaged tissue.

GPC-based Treatment for CNS Diseases

In recent years, it has become more and more clear that a number of neurodegenerative and psychiatric disorders are causally linked to glial dysfunction, besides the glial disorders of oligodendrocyte loss and myelin failures. For glial cell-related diseases, modulating the glial reparative response by either transplantation or mobilization of allogeneic GPCs may be a logical intervention for obtaining therapeutic improvement. For example, progressive MS might comprise an especially attractive target for a glial replacement since oligodendrocyte engagement with otherwise denuded axons might serve to preserve neuronal viability even in the absence of remyelination. The delivery of GPCs into the demyelinated brain may thus offer tangible benefits by oligodendroglial replacement and axonal engagement perse, as well as by myelin repair.

Fig.2 Glial progenitor cell sources, phenotypes, and clinical targets. (Goldman, 2017)

Services at Creative Biolabs

GPCs derived from pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are considered as an attractive in vitro model for studying the pathology of CNS disorders for the identification of novel drug targets and development of therapeutic drugs. As an experienced expert in STEMOD™ models, Creative Biolabs provides comprehensive custom services for neural differentiation from the glial progenitors to effectively support your neuroscience research. Our diverse STEMOD™ ex vivo model offers an advanced platform for a series of custom differentiation services, including but not limited to:

Our highly skilled team of scientists will custom design a differentiation protocol according to the specific needs of the client. Depending on the exact requirements of your project, we can utilize different differentiation methods or adjust the time course of differentiation to yield a higher percentage of your cell type of interest.

Our service is reliable, efficient and highly customizable, which allows researchers to receive cells that specifically match their experimental need. This ensures that the cells are suitable for a variety of molecular and cellular studies.
We can provide these GPCs in various formats including cells in culture dishes, cryopreserved vials of cells, or RNA/DNA/protein extracted from these cells. This allows researchers to deploy these cells directly for their research purpose, which can range from drug discovery to disease modeling.
Every order of custom glial progenitors is accompanied by a comprehensive documentation package, including cell line authentication, quality control testing results, and documentation of the cell's pluripotent status.

Our aim is to ensure your research is as seamless as possible, offering not just high-quality cell products, but a comprehensive solution for your needs.

Services	Descriptions
High-efficient Astrocyte Differentiation Technology	Creative Biolabs, with well-established differentiation platforms, can rapidly and efficiently generate human astrocytes of high quality, regarding morphology, molecule profile, and function. We provide custom astrocyte differentiation services to our clients worldwide to facilitate your research.
Custom CNS Disease Modeling Services	We have optimized our neuroscience in vitro model platform with advanced technologies, high-quality facilities, and professional experts. Our platform can offer reliable custom CNS disease modeling services including but not limited to Alzheimer's disease models, Huntington's disease models, and Parkinson's disease models.
Primary Cell Lines	Primary cell lines have great significance in neuroscience research and are among the most important neuroscience research tools. As a professional in neuro-based research, Creative Biolabs has invested a lot of manpower, material resources, and financial resources in neuroscience-based primary cell lines and the development of relevant custom productions.

Applications

This innovative service is geared towards researchers and institutions that necessitate high-quality, well-characterized glial progenitors for various scientific applications. These differentiated cells' applications are broad, spanning disease modeling, drug testing, cell therapy, and studying developmental biology.

Disease Modeling: these cells can be used to study neurodegenerative disorders like Alzheimer's disease, multiple sclerosis, or psychiatric disorders like schizophrenia.
Cell Therapies: glial progenitors have potential roles in remyelination strategies for demyelinating diseases such as MS and certain types of spinal cord injuries.
CNS Drug Discovery: These cells could also be used to identify and test novel drug targets, especially in neurodegenerative disorders.

FAQs

Q: How long does it generally take to complete the service?

A: The timescale can vary depending upon the specifics of each project such as the scale and complexity of the differentiation required. However, on average, the entire process of differentiation and validation usually takes approximately 3 to 4 weeks.

Q: Is the service compatible with large scale projects?

A: Absolutely, our custom glial progenitors differentiation service can accommodate both small and large scale projects. We have the capacity and expertise to handle large volume orders while maintaining the strict adherence to quality and ethical guidelines.

Q: Can the differentiation process be customized to induce a specific disease model?

A: Absolutely, we have the capability and expertise to modify the differentiation process to create specific disease models in glial progenitors. This allows for enhanced understanding of disease mechanisms, drug testing and therapeutic development.

Q: Can you provide the cells in a specific media upon my requirement?

A: Yes, we can provide the differentiated glial progenitors in a variety of media depending upon your needs. We work closely with our clients to determine the best culture conditions for the cells to ensure optimal results for further applications.

Scientific Resources

Molecular and Cellular Neuroscience

Regulation and Drive of Neuronal Differentiation

Thanks to a longstanding presence in the field of neuroscience ex vivo models, Creative Biolabs is the right partner to navigate the astrocyte differentiation challenges. We are pleased to provide support for any of your questions. What you need to do is feel free to send us your specific demands. Our professional scientist will reply to you as soon as possible.

Reference

Goldman, S. A. Progenitor cell-based treatment of glial disease. Progress in brain research. 2017, 231, 165-189.

For Research Use Only. Not For Clinical Use.