The amino acid G-amino-butyric-acid (GABA) is the major inhibitory neurotransmitter in the mature brain and plays an important role in regulating neuronal activity levels and synaptic plasticity, controlling the formation and propagation of neuronal activity, and generating local and large-scale oscillatory activity. In accordance with these diverse GABAergic functions, different classes of neocortical GABAergic interneurons with specific electrophysiological properties, dendritic morphologies, and axonal projection patterns have been identified and classified. In the mature midbrain, GABAergic neurons are found in several locations and participate in many important brain functions. Knowledge of GABAergic neuron development is highly important for understanding their diversity and function and may provide new approaches to the treatment of neurological and psychiatric disease.
Fig.1 GABAergic and glutamatergic domains and their gene-expression in the developing. (Achim, 2014)
Diverse Mechanisms Regulate GABAergic Neuron Differentiation
No single transcription factor (TF) involved in patterning, neurogenesis or differentiation of GABAergic neurons is shared by all the GABAergic neuron populations. On the other hand, most of the TFs important for GABAergic neuron development also have functions in other neuronal lineages or cell types.
Spatial patterning and progenitor specification HD or bHLH proteins
Proneural genes and their regulators bHLH proteins
Focusing on custom neural differentiation models over years, Creative Biolabs has accumulated extensive experience and gradually established our own technology platform. During these years of exploration, we have trained a lot of experts specialized in these fields. With an excellent professional team, strong foundations, and rich experience, we are confident in offering customer-satisfied custom GABAergic neurons differentiation model service to global clients.
If you are interested in custom GABAergic neurons differentiation model service, or you any other models on our website, please don't hesitate to contact us for more information.
Achim, K., et al. Mechanisms regulating GABAergic neuron development. Cell Mol Life Sci. 2014, 71(8): 1395-415.