Ligand-gated Channel Screening Services

Ligand-gated channels, also known as ligand-gated ion channels and ionotropic receptors, are a kind of ion channel for ion transmembrane transduction when a ligand is bound. Ligand-gated channel screening helps to find the ligand with high specificity and responsiveness towards your interested ion channels. With a comprehensive cell modeling platform and rich readily available cell models, Creative Biolabs provides trustworthy ligand-gated channel screening services to help scientists across the world with their study.

Introduction of Ligand-gated Channel

Ligand-gated channels typically have at least 2 domains to support the function. One is the transmembrane domain, forming the pore for ion transduction, while the other one is the extracellular domain, including the ligand binding site. Usually, the ligand will bind to the receptor of the extracellular domain, induce the ion channel part to the open state for successful ion transduction. Besides ligand, membrane potential change and channel blockers can also influence the performance of ligand-gated channels. Ligand-gated channels own 3 superfamilies called ATP-gated channels, cys-loop receptors, and ionotropic glutamate receptors with well-known examples like P2X receptors, GAB_AA receptor, and NMDA receptor, respectively.

Fig.1 Working principle of ligand-gated calcium channel.Distributed under Public Domain, from Wiki.

Ligand-gated Channel Screening Service

Numerous studies indicate that ligand-gated channels are linked to diseases and disorders such as GABA_A receptors in epilepsy and NMDA receptors in Alzheimer's disease. Research on ligand-gated channels provides another aspect to discover the disease occurrence, development, and treatment. Ligand-gated channel screening is a useful method for in vitro pharmacological research since it allows scientists to identify promising activators or inhibitors of certain ligand-gated channels.

Both electrophysiological technologies, for instance patch clamp and automated patch clamp, and non-electrophysiological high-throughput strategies such as flux-based assay and fluorescence-based assay are popular methods with remarkable discovery in the history of ligand-gated channel screening.

A proper and function-confirmed cell line is the key to the success of channel screening services. Combined with our well-established cell model construction platform, Creative Biolabs is equipped to offer a range of different ligand-gated channel screening services, including but not limited to:

• CNG Channel Screening
• NMDA Receptor Screening
• nAChR Screening
• GABA_AR Screening
• AMPAR Screening
• P2X Receptor Screening
• TRP Channel Screening
• Calcium-activated Channel Screening
• Sodium-activated Channel Screening

Features of Our Service

• Tailored assay development
• Custom cell model acceptable
• Quality-guaranteed service but efficient cost
• Repeatable results and comprehensive analysis
• Fast turnaround time and best after-sale service

Creative Biolabs provides one-stop service for your ligand-gated channel screening project. Do not hesitate to contact us for more details.

In addition to Ligand-gated Channel Screening, Creative Biolabs also provides you with

• Potassium Channel Screening
• Sodium Channel Screening
• Calcium Channel Screening

For Research Use Only. Not For Clinical Use.