Sodium Channel Screening Service

Sodium channels, as members of the cation channel superfamily, are predominantly present in excitable cells like endocrine cells, neurons, and muscle cells for allowing sodium influx along an electrochemical gradient. Creative Biolabs can speed up your project research on sodium channel screening by our outstanding scientific experts in the ion channel screening field.

Introduction of Sodium Channel

Sodium channels transport the sodium ions via membrane-integral protein-formed ion channels, to function at the rising stage of an action potential. Large alpha subunits with/without the accessory proteins like beta subunits consist the sodium channel. Six membrane-spanning segments marked as S1 to S6 consist a repeat domain, and four repeat domains labelled as I to IV form the large alpha subunit, which comprises the core part of the channel, forming a pore for conducting sodium ions in voltage-dependent way, and is functional itself, even without the accessory proteins. The conserved membrane-spanning segment S4 functions as the voltage sensor, whose amino acids containing positive charge at every third position confer to the voltage sensitivity. When involving accessory proteins such as beta subunits, the channel location and voltage dependence may be changed. Impaired or abolished function of sodium channel may lead to cardiovascular diseases or neuronal disease like epilepsy.

Fig.1 The structure of alpha subunit-based voltage-dependent sodium channel.Distributed under CC BY-SA 3.0, from Wiki, without modification.

Sodium Channel Screening Service

As one of the most important ion channel type, sodium channels are critical for many physiological functions in mammals, also as attractive therapeutic targets. Discovering the potential modulators via sodium channel screening paves a path for in vitro disease pharmacology studies resolving the sodium channel-associated disease.

Patch-clamp leading electrophysiological method is a standard for ion channel research because of its strengths like precise voltage control, high temporal resolution, and reliable repetitive stimulation. Sodium channel screening services also benefit from this to unlock many key clues in disease research, though the method is costly and laborious in some degree.

High-throughput based technologies like yeast-two-hybrid strategy and electro-optical method greatly expand the assay scope of sodium channel screening from specific samples to a custom compound library. Such non-electrophysiological strategies are cost-effective and labor-saving, and are gradually noticed by scientists and applied in their projects to find the trustable candidates as inhibitors or activators of voltage-dependent sodium channels.

Fig.2 Simple workflow of high-throughput screening for specific sodium channel mediators.

Some voltage-sensitive sodium channels are shared here. For your sodium channel screening research, you have the option of using both commercially available and bespoke cell models.

Features of Our Service

• Commercially available and bespoke sodium channel cell lines for choice
• Custom assay development and treatment
• Quality-guaranteed and cost-saving screening service
• Time-saving reporting and comprehensive data analysis
• Reliable results and best after-sale service

Creative Biolabs, as a world-famous supplier, enables all kinds of sodium channel screening service to enhance your research projects towards your interested sodium channels. Feel free to contact us for more details.

In addition to Sodium Channel Screening, Creative Biolabs also provides you with

• Potassium Channel Screening
• Calcium Channel Screening
• Ligand-gated Channel Screening

For Research Use Only. Not For Clinical Use.