A powerful technique used in neuroscience research is the enzyme-linked immunosorbent assay (ELISA). ELISA plays a key role in detecting and quantifying these targets of neurotransmitter-related enzymes and receptors, neurotrophic factors and receptors, and synaptic proteins and receptors, providing valuable insights into the underlying mechanisms and potential therapeutic strategies for neurological disorders.
Here, Creative Biolabs will focus on these common ELISA targets involved in the field of neuroscience to help you advance your scientific research.
Neurotransmitters are chemicals released through synapses that allow signals to be transmitted from presynaptic neurons to postsynaptic target cells. Neurotransmitters are critical to the function of complex nervous systems, and synaptic failure and neurotransmitter dysfunction underlie many neurodegenerative diseases. Therefore, the study of neurotransmitter-related targets is crucial for the functional study of the nervous system.
Neurotransmitter receptors, transporters and ion channels
Allograft Inflammatory Factor 1 (AIF1)
Annexin A1 (ANXA1)
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
S100 Calcium Binding Protein A8 (S100A8)
S100 Calcium Binding Protein A9 (S100A9)
S100 Calcium Binding Protein A12 (S100A12)
S100 Calcium Binding Protein B (S100B)
Neurotrophic Factors and Receptors-Related Targets
Neurotrophic factors (NTFs) are a family of biomolecules. The vast majority of NTFs are peptides or small molecule protein structures that are closely associated with the survival, growth and differentiation of developing and maturing neurons.
Neurotrophic factors enter nerve endings as receptor-mediated entry cells and play a role in supporting neuronal growth, development and functional integrity. They also play a putative role in the regeneration of the nervous system after injury and have the potential to treat neurodegenerative diseases.
Synaptic proteins (SPs) are a family of neuron-specific phosphorylated proteins associated with synaptic vesicles. They are present on the surface of almost all synaptic particles and are bound to the cytoskeleton and can be phosphorylated by calmodulin and cAMP-dependent protein kinases.
Synaptic dysfunction is a prominent feature of many neuropathological diseases, including Alzheimer's disease, Parkinson's disease, and other dementias. Therefore, relevant target studies are also crucial for some neurological disease research.
Synaptic proteins and receptor-related targets
Chromogranin A (CHGA)
Microtubule Associated Protein Tau/Tau Protein (MAPτ)
Neural Cell Adhesion Molecule (NCAM/CD56)
phosphorylated microtubule-associated protein tau (pMAPT/pTAU)
Synuclein Alpha (SNCα)
By using ELISA, scientists can identify potential therapeutic targets, validate drug candidates and develop novel diagnostics for neurological disorders. As ELISA technology continues to advance, the future of neuroscience research holds great promise for further unlocking the mysteries of the brain and improving human health.
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