Neuronal markers are crucial for identifying, isolating, and studying various types of neurons both in vitro and in vivo. Creative Biolabs is a leading provider of products and services related to neuronal markers. At our company, we pride ourselves on being able to provide a wide range of products and services that cater to neuronal markers.
What is a Neuronal Marker?
The panoply of neuronal markers consists of an assortment of proteins, molecules, and genes that are exclusively synthesized by neurons or selected subsets thereof. These markers are exploited by researchers to discriminate, extract, and scrutinize certain types of neurons. They furnish molecular or cellular traits that allow researchers to differentiate between distinct neuron types grounded on variables such as function, structure, location, or connections, and to delve into their functions within the intricate neural networks of the brain.
Types of Neuronal Markers
Neuronal markers can be classified into different categories based on their cellular location, function, and specificity. Some of the most commonly used neuronal markers include:
Neuron-specific proteins. Such as neuronal nuclei (NeuN), microtubule-associated protein 2 (MAP2), and βIII-tubulin, they are widely used to identify and quantify neurons in histological sections or cultures.
Neuronal subtype markers. Different types of neurons express unique combinations of proteins, receptors, or neurotransmitters that define their identity and function.
Activity-dependent markers. Neurons that are activated by specific stimuli or tasks can express immediate early genes (IEGs), which can be used as markers of neuronal activity to identify and map the neural circuits.
Genetic markers. The genetic markers allow researchers to visualize and manipulate specific types of neurons in live animals and to study their functions in real-time.
Applications of Neuronal Marker
Neuronal markers have a broad range of uses in neuroscience research.
Identifying and categorizing neurons. By analyzing these markers, scientists can gain a better understanding of the different functions and roles that specific neurons play within the complex circuitry of the brain.
Mapping neuronal connections. Neuronal markers can be used to trace the axonal projections and synaptic connectivity of specific neuron types.
Manipulating and modulating neurons. Researchers can selectively manipulate or modulate the activity of specific neurons using optogenetics, chemogenetics, or other techniques, with the aid of neuronal markers.
Diagnosing neurological disorders and discovering biomarkers. Neuronal markers can serve as diagnostic tools and biomarkers for neurological disorders.
Common Detection Techniques
There exist a myriad of techniques available for detecting neuronal markers with neuronal marker antibody, each with its own unique advantages and limitations, such as various immunostaining:
In situ hybridization (ISH)
At Creative Biolabs, our team of experts is committed to leveraging the power of neuronal markers to assist researchers in comprehending the intricate circuitry of the brain. We pride ourselves on delivering high-quality services and would be thrilled to provide you with further information. If you require additional details or assistance, please do not hesitate to contact us, and we'll be happy to help.
Tam W Y, et al. In search of molecular markers for cerebellar neurons. International Journal of Molecular Sciences, 2021, 22(4): 1850.
Gusel'Nikova V V and Korzhevskiy D E. NeuN as a neuronal nuclear antigen and neuron differentiation marker. Acta Naturae, 2015, 7(2(25)): 42-47.