Online Inquiry

For Research Use Only. Not For Clinical Use.

Contact Us
  • Email:

Optogenetics in the Treatment of Neurological Diseases

The intersection of neuroscience and technology has led to groundbreaking innovations, one of which is optogenetics. This cutting-edge technology has shown tremendous potential for the study and treatment of neurological disorders.

As a leading force in neuroscience research, Creative Biolabs explores the promise of optogenetics in transforming the treatment of neurological disorders and provides optogenetic tools as basic neuroscience research tools.

Services What We Do Advantages
Calcium Assay Service We offer novel calcium assays to clients around the world, including customized simple and quantitative methods for measuring calcium in different biological fluids.
  • Simple operation process
  • Rapid detection
  • High sensitivity
  • Wide range of applications
  • Multiple sample types
Neuronal Activity Monitor Services Neuronal activity monitoring service is one of the proven services provided by our platform. We are able to provide novel tools for imaging and recording neuronal activity in animals to capture neural activity.
  • Novel tool development
  • The most realistic readings
  • Real-time imaging
Optogenetic Actuators We offer the search for novel Optogenetic Actuators and genetic alterations to existing actuators, which enable precise optical control of single-cell activity with high temporal resolution.
  • Highly specialized staff
  • Advanced platforms
  • Comprehensive support and tools
Optogenetic Indicators We provide optogenetic tools, including a variety of optogenetic indicators that can be easily delivered to target neuronal populations, using a variety of genetic approaches to achieve cell type-specific manipulation.
  • Does not affect other cells
  • Compatibility with genetics
  • Wide range of applications
STEMOD™ Advanced Drug Discovery Service We develop integrated technology platforms to provide one-stop CNS drug discovery services, including studies on BBB transport and distribution in the brain.
  • Advanced technology
  • Quality facilities
  • Professional experts

Introduction to Optogenetic Tools

Optogenetics is a multidisciplinary field that is a method of manipulating neural activity. This technique was made possible with the discovery of light-sensitive proteins, such as microbial optic proteins, which can be genetically engineered into neurons to respond to light stimuli. Channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR) are two typical players that have enabled researchers with precise temporal and spatial control to excite or inhibit neurons.

Common opsins used in optogenetics.Fig. 1 Common opsins used in optogenetics.1

Optogenetics decodes neural circuits, allowing us to gain a deeper understanding of the neural underpinnings of diseases such as Parkinson's disease, epilepsy and depression. In addition, it also regulates the release of neurotransmitters, allowing researchers to gain insight into the molecular basis of various neurological disorders.

Optogenetics in the Treatment of Neurological Diseases

  • Dawn of Parkinson's disease

Parkinson's disease, characterized by the degeneration of dopaminergic neurons in the substantia nigra, has long been a target for optogenetic intervention. By expressing light-sensitive proteins in specific regions of the brain, researchers have successfully alleviated motor symptoms in animal models of Parkinson's disease.

    • Use optogenetics to modulate the activity of the basal ganglia, a key brain region implicated in Parkinson's disease
    • Target the subthalamic nucleus with light-sensitive proteins to alleviate motor symptoms in animal models
  • Seizing Control in Epilepsy

Optogenetics offers a new avenue of intervention by controlling the excitability of neurons associated with seizures in real time. By precisely modulating neural activity, researchers aim to develop optogenetic therapies that can effectively suppress seizures while minimizing side effects.

    • Use optogenetics to selectively activate or inhibit specific neuronal populations involved in seizure generation
    • Target the hippocampus or other seizure-prone regions
  • Lighting the Shadow of Depression and Anxiety

Optogenetics allows researchers to explore the complexity of the brain's reward circuitry and identify potential targets for therapeutic intervention. Light-induced modulation of specific neurons promises the development of targeted therapies that may revolutionize the treatment of depression.

    • Employ optogenetics to modulate the activity of the prefrontal cortex, amygdala, and other brain regions involved in the regulation of mood and emotion
    • Target specific neural pathways implicated in mood disorder
  • More effective therapeutic strategies for Alzheimer’s Disease

Alzheimer's disease (AD), a progressive neurodegenerative disorder, involves complex pathogenic processes, including synaptic loss and neuronal cell death. Several preclinical optogenetic studies on AD emphasize the immense potential in mapping, dissecting, and modifying neuronal circuits disrupted by neurotoxic beta-amyloid plaques.

Pioneering Optogenetic Solutions

Creative Biolabs is a key player in advancing optogenetic solutions for neurological disorders. We integrate cutting-edge technologies to facilitate the design and development of customized optogenetic tools for specific research and therapeutic needs.

  • Customized Optogenetic Tools
    From engineered microbial visual proteins to custom viral vectors, our solutions enable scientists to design and implement precision-targeted experiments using state-of-the-art optogenetic technologies.
  • Cutting-edge Delivery Systems
    We use nanoparticle technology, non-viral vectors, and implantable devices, among others, to ensure precise and controlled modulation of neural circuits for targeted stimulation of specific brain regions.
  • Safety Assurance
    We conduct rigorous preclinical evaluations and adhere to strict safety protocols.

Challenges and Future Directions

Despite the remarkable potential of optogenetics, the approach does come with certain limitations and challenges.

Limitations and Challenges Future Directions
It requires the genetic modification of specific neurons to express light-sensitive proteins, which raises ethical and safety concerns. Furthermore, the intricacy of human brain circuits may also limit its implementation.
  • Further advancements and regulatory guidelines in optogenetics
The invasive nature of optogenetic treatment, requiring the implantation of light-emitting devices into the brain, is another limiting factor.
  • Development in minimally invasive surgical techniques
  • Advances in biocompatible materials for device manufacture
The specificity and control of optogenetics can also be a double-edged sword. While it allows the accurate manipulation of targeted neurons, an in-depth understanding of the altered neural circuits in various diseases is vital to ensure safe and effective treatment.
  • Capacity to modify or correct abnormal neuronal activity patterns

Optogenetics, through its ability to selectively control neuronal activity, offers a promising avenue to treat neurological diseases. It lights the way for neuroscientists towards a deeper understanding of complex brain function, bringing unparalleled opportunities to ameliorate the burdens of neurological disorders and contribute to a healthier world.

Creative Biolabs integrates a multidisciplinary approach of molecular biology, genetics and optics to design and develop customized optogenetic tools to advance the optogenetic solution side of neurological disorders.


  1. Pourbadie Hamid Gholami and Mohammad Sayyah. "Optogenetics: control of brain using light." Iranian Biomedical Journal 22.1 (2018): 4.

For Research Use Only. Not For Clinical Use.