How are the cells shipped?

Cells are shipped cryopreserved on dry ice to ensure maximum viability upon arrival at your facility.

Can I order cells derived from a specific patient population?

We offer several iPSC-derived neural cell lines from donors with diagnosed diseases like Alzheimer's and Parkinson's. We also offer custom iPSC reprogramming services to generate patient-specific lines for your unique research needs.

Do you offer technical support if I have trouble with the cells?

Yes, our team of experienced neuroscientists is available to provide comprehensive technical support, from protocol optimization to data interpretation.

What is the main advantage of using iPSC-derived neural cells over immortalized cell lines?

Our iPSC-derived cells provide a much more physiologically relevant model. They are human-derived, can carry disease-specific mutations, and differentiate into functional, post-mitotic neurons that form synaptic networks. This more closely mimics the in vivo environment compared to cancerous, proliferative cell lines, leading to more translatable data.

Do you offer cells with specific genetic mutations related to my disease of interest?

Yes, we have a growing library of cell lines with common mutations for diseases like Parkinson's (e.g., LRRK2, SNCA) and Alzheimer's (e.g., APOE4, PSEN1). If you don't see what you need, we also offer custom engineering services. This allows you to study the direct impact of a specific mutation in a controlled human genetic background.

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Neural Disease Model Products

Introduction Advantages Portfolio Features FAQs Related Product Sections Product List

Introduction

Elucidating the mechanisms of the human nervous system, biomedicine's final frontier, represents a paramount scientific challenge, particularly concerning neurological disorders like neurodegeneration and stroke. Progress is critically dependent on advanced, biologically congruous research models.

To address this, we have engineered a comprehensive portfolio of validated neural disease cell products. These sophisticated biological systems empower researchers to transcend the limitations of conventional models, accelerating the translational pipeline from discovery to clinical intervention. For over a decade, Creative Biolabs has supplied the global scientific community with these essential tools, which are founded on scientific rigor and technological innovation. Our cell products are not mere reagents; they are meticulously validated platforms providing a clear window into the intricate pathophysiology of the human brain, designed to propel research forward.

Contact our neuroscience specialists today to find the precise cellular model for your research needs, inquire about a custom model, and let's begin our collaboration to unravel the complexities of the nervous system.

You may also directly consult our comprehensive Product List for specific offerings.

Advantages: Your Partner in Discovery

Incorporating Creative Biolabs' neural cell products into your research offers a significant strategic advantage, helping to shorten your project timelines and amplify the impact of your scientific discoveries.

A Comprehensive Portfolio: Cellular Models for Diverse Neurological Indications

Our product catalog is strategically designed to facilitate research into the entire spectrum of neurological and psychiatric conditions.

Diseases	Description
Neurodegenerative Diseases	Elucidate the fundamental pathogenic mechanisms of diseases such as Alzheimer's, Parkinson's, and ALS. We supply iPSC-derived cortical, dopaminergic, and motor neurons, in addition to primary cells and cell lines, to model key pathological events including Aβ toxicity, tauopathy, and the aggregation of alpha-synuclein.
Neuromuscular & Genetic Diseases	Probe the cellular underpinnings of conditions like Huntington's disease and muscular dystrophy using our specialized iPSC-derived motor neurons and other pertinent cell types, which are engineered for research on synaptic transmission and muscle innervation.
Autoimmune & Inflammatory Diseases	Recreate the intricate crosstalk between the nervous and immune systems characteristic of conditions such as Multiple Sclerosis and neurosarcoidosis. We provide neuron-glia co-cultures, microglia, astrocytes, and complete blood-brain barrier (BBB) models to facilitate studies on neuroinflammation, demyelination, and the infiltration of immune cells.
Pain & Functional Diseases	Accelerate the discovery of new analgesics with our human iPSC-derived sensory neurons. These cells are perfectly suited for investigating nociception, neuropathic pain, and channelopathies, offering a robust platform for the high-throughput screening of compounds aimed at modulating pain pathways.
Structural & Developmental Diseases	Deconstruct the mechanisms underlying conditions like Epilepsy, Autism Spectrum Disorder, and Rett syndrome. Our portfolio, including neural progenitor cells (NPCs), iPSC-derived neurons, and bespoke differentiation services, permits detailed analysis of neuronal migration, synapse development, and network excitability.
Rare & Metabolic Diseases	For rare genetic and metabolic disorders affecting the nervous system, our custom iPSC reprogramming and differentiation services are invaluable. We can generate patient-specific cell models that carry the precise genetic mutations of interest, enabling targeted therapeutic development.

Key Features: The Creative Biolabs Standard

When you choose Creative Biolabs, you are investing in more than just cells; you are accessing a platform built on stringent quality control, cutting-edge cell engineering, and an unwavering commitment to scientific advancement.

Features	Description
Unrivaled Purity & Viability	Our cell products, including primary neurons and iPSC-derived lines, consistently exceed 90% purity. Each batch is rigorously tested and confirmed negative for common contaminants like mycoplasma, bacteria, and fungi, ensuring your experiments start with a clean slate.
Diverse & Comprehensive Portfolio	We offer a vast selection of cell types, including primary neurons from various species (rat, mouse), human primary cells, immortalized cell lines, and a state-of-the-art collection of human induced pluripotent stem cell (iPSC)-derived neurons. This diversity allows you to select the model that best fits your specific research question.
Advanced Cellular Engineering	Leveraging sophisticated techniques like CRISPR/Cas9 and lentiviral transfection, we develop stable cell lines with specific gene knockouts, knock-ins, or overexpression capabilities. This allows for precise investigation of gene function in disease pathology.
Rich Phenotypic Characterization	Our cells are not just validated for identity and purity. Many of our models, particularly our iPSC-derived lines, undergo functional characterization, including electrophysiological analysis with multi-electrode arrays (MEA), to ensure they exhibit the expected physiological activity.
Disease-Specific Relevance	We have developed a unique collection of iPSC-derived neural progenitors and mature neurons from donors with diagnosed neurological conditions, including Alzheimer's, Parkinson's, and Epilepsy. These models provide a powerful window into human disease pathology.

A picture that presents Common targets of various neurological disorders. (Puri, et al., 2022) (OA Literature)

Fig.1 Common targets of various neurological disorders.¹

FAQs

How are the cells shipped?
Cells are shipped cryopreserved on dry ice to ensure maximum viability upon arrival at your facility.
Can I order cells derived from a specific patient population?
We offer several iPSC-derived neural cell lines from donors with diagnosed diseases like Alzheimer's and Parkinson's. We also offer custom iPSC reprogramming services to generate patient-specific lines for your unique research needs.
Do you offer technical support if I have trouble with the cells?
Yes, our team of experienced neuroscientists is available to provide comprehensive technical support, from protocol optimization to data interpretation.
What is the main advantage of using iPSC-derived neural cells over immortalized cell lines?
Our iPSC-derived cells provide a much more physiologically relevant model. They are human-derived, can carry disease-specific mutations, and differentiate into functional, post-mitotic neurons that form synaptic networks. This more closely mimics the in vivo environment compared to cancerous, proliferative cell lines, leading to more translatable data.
Do you offer cells with specific genetic mutations related to my disease of interest?
Yes, we have a growing library of cell lines with common mutations for diseases like Parkinson's (e.g., LRRK2, SNCA) and Alzheimer's (e.g., APOE4, PSEN1). If you don't see what you need, we also offer custom engineering services. This allows you to study the direct impact of a specific mutation in a controlled human genetic background.

Progress in neuroscience is contingent upon pioneering tools that yield definitive and unambiguous data. At Creative Biolabs, our mission is to supply you with neural cell products of the highest caliber and physiological fidelity, ensuring your work remains at the forefront of the discipline.

Whether your project demands a thoroughly characterized cell line for a high-throughput screening initiative or a bespoke, patient-specific model to test a novel hypothesis, our team possesses the technical capability and deep expertise to meet your requirements. Contact us today to discuss your project and let us provide the cells that will drive your next discovery.