Why use a cell model for CIDP research?

Cell models provide a controlled, reproducible system to study the specific molecular and cellular events of the disease, which can be difficult to isolate in complex animal models or human subjects. They are ideal for high-throughput screening and detailed mechanistic studies.

Are the models suitable for high-throughput screening (HTS)?

Many of our models are adaptable to 96- or 384-well plate formats, making them highly suitable for HTS campaigns.

Can I test the effect of my specific therapeutic compound?

Absolutely. Our platforms are designed for screening a wide range of therapeutics, including small molecules, monoclonal antibodies, and other biologics.

Can these models help in understanding diagnostic test results, like VEPs or MRI?

While our models don't perform VEPs, they can help uncover the cellular basis for clinical findings. For instance, you can study the specific axonal or myelin damage that may lead to the abnormal VEPs or MRI T2 hyperintensity seen in patients.

Do you offer custom model development?

Yes. We pride ourselves on our collaborative approach. If you have a specific hypothesis or need a unique model system, our R&D team will work with you to design, develop, and validate a bespoke model.

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Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Cell Model Products

Introduction Features Advantages Portfolio Applications FAQs Related Product Sections Product List

Introduction

Unraveling the complex pathology of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)—from neuroinflammation and demyelination to remyelination failure—requires sophisticated and reliable research models. At Creative Biolabs, we specialize in developing high-fidelity MS cell models that empower researchers to move beyond these limitations. Our robust, well-characterized cellular systems provide the predictive power and reproducibility you need to accelerate your therapeutic pipeline, from target validation to preclinical screening. Contact our MS Model Specialists to discuss how our advanced in vitro models can bring clarity to your research and to receive a quote today.

Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.

Features

Our CIDP cell models are specifically designed to recapitulate the key pathological hallmarks of the disease:

Features	Description
Verified Demyelination	Models robustly recapitulate the core process of myelin sheath destruction by immune cells.
Authentic Immune Infiltration	Our co-culture systems incorporate key immune players, including T-cells and macrophages, to simulate the inflammatory assault on peripheral nerves.
Paranodal Junction Disruption	We offer specialized models to investigate the role of antibodies against nodal and paranodal proteins like Neurofascin-155 (NF155) and Contactin-1 (CNTN1), a critical feature in specific CIDP subtypes.
Subtype Specificity	Models can be tailored to represent various clinical phenotypes, including typical, distal, and multifocal forms of CIDP.
High Reproducibility	Each model is rigorously validated for consistency, ensuring reliable and reproducible data across experiments.
Comprehensive Readouts	Compatible with a wide array of analytical methods, including high-content imaging, electrophysiology, and biomarker assays.

Advantages

Gain Clinically Relevant Insights

Move beyond generic models. Study the specific mechanisms of typical CIDP, DADS, or even rare paranodopathies to generate data that truly reflects the clinical reality.

Achieve High-Fidelity Data

Our validated, biologically relevant models provide a reliable alternative to animal models, which can be costly and may not fully replicate the human disease spectrum.

Accelerate Your Discovery Timeline

Bypass the time-consuming process of model development. Our ready-to-use platforms allow you to proceed directly to compound screening and mechanistic studies, saving you valuable time and resources.

Access Unmatched Expertise

Leverage our 20+ years of experience in cell biology and neuroimmunology. Our expert team is available to help you select the optimal model and design a robust experimental plan.

Creative Biolabs' Innovative CIDP Cell Model Portfolio

Leveraging decades of expertise in neurobiology and immunology, Creative Biolabs has developed a suite of robust and highly characterized CIDP cell models. Our platforms are engineered to simulate key aspects of CIDP pathology, providing you with the tools necessary to ask complex biological questions and obtain actionable data.

Types	Description
Neuron-Schwann Cell Myelination Co-Culture Systems	Our co-culture models form mature, compact myelin sheaths in vitro, creating an ideal system to study both myelination and the demyelinating attacks that define CIDP. Available with primary human or iPSC-derived cells, these models are highly versatile for inducing demyelination. They are ideal for screening compounds that prevent demyelination or promote remyelination and for investigating the mechanisms of myelin sheath degradation.
Immune-Mediated CIDP Models	To precisely recapitulate the autoimmune pathogenesis of CIDP, we provide co-culture platforms that incorporate key immune cell populations. These adaptable systems, integrating neurons, Schwann cells, and immune effectors like T-cells and macrophages, mimic the inflammatory signaling pathways that result in nerve damage. They serve as an optimal platform for assessing immunomodulatory drugs, elucidating mechanisms of immune attack, and discovering novel therapeutic targets.
Patient-Derived iPSC Models for CIDP	Unlock personalized medicine with our custom iPSC services. We generate iPSCs from your CIDP patient cohort and differentiate them into active neurons and Schwann cells. Carrying the donor's unique genetic background, these "disease-in-a-dish" models provide an unparalleled view into individual-specific aspects of the disease. Use them to investigate genetic risk factors, test drug efficacy on a patient-specific basis, and explore mechanisms behind treatment-resistant CIDP.

Applications

Our CIDP cell models are versatile tools designed to support a wide range of research objectives:

Therapeutic Screening: Efficiently screen small molecules, biologics, and immunomodulatory agents for their ability to prevent demyelination or promote remyelination.
Pathogenesis Investigation: Elucidate the complex interplay between immune cells, autoantibodies, and peripheral nerve cells in a controlled in vitro setting.
Biomarker Validation: Investigate how potential diagnostic or prognostic biomarkers, such as specific cytokines or antibodies, correlate with cellular pathology and treatment response.
Patient Stratification Modeling: Develop models representing distinct CIDP subtypes, such as those with anti-NF155 or anti-CNTN1 antibodies, to understand differential treatment responses. This allows for testing why certain patient cohorts respond poorly to standard therapies like IVIg while potentially benefiting from agents like rituximab.
Mechanism of Action (MoA) Studies: Determine the precise molecular pathways through which your therapeutic candidate exerts its effects on Schwann cells, axons, and immune components.

A picture that presents the Common manifestations present in CIDP patients. (Brun, et al., 2022) (OA Literature)

Fig.1 Common manifestations present in patients with CIDP.¹

FAQs

Why use a cell model for CIDP research?
Cell models provide a controlled, reproducible system to study the specific molecular and cellular events of the disease, which can be difficult to isolate in complex animal models or human subjects. They are ideal for high-throughput screening and detailed mechanistic studies.
Are the models suitable for high-throughput screening (HTS)?
Many of our models are adaptable to 96- or 384-well plate formats, making them highly suitable for HTS campaigns.
Can I test the effect of my specific therapeutic compound?
Absolutely. Our platforms are designed for screening a wide range of therapeutics, including small molecules, monoclonal antibodies, and other biologics.
Can these models help in understanding diagnostic test results, like VEPs or MRI?
While our models don't perform VEPs, they can help uncover the cellular basis for clinical findings. For instance, you can study the specific axonal or myelin damage that may lead to the abnormal VEPs or MRI T2 hyperintensity seen in patients.
Do you offer custom model development?
Yes. We pride ourselves on our collaborative approach. If you have a specific hypothesis or need a unique model system, our R&D team will work with you to design, develop, and validate a bespoke model.

Specialized tools and deep expertise are essential for navigating the complexities of CIDP. Creative Biolabs is committed to providing the innovative cell models you need to dissect disease mechanisms, identify novel drug targets, and accelerate the development of next-generation therapies. Don't let the challenges of CIDP research slow your progress. Contact our specialists today to learn more about our CIDP cell model services and to get a customized quote for your project.