Why are iPSC models superior to animal models for ALS research?

iPSC models use human cells, allowing them to better recapitulate human-specific genetic backgrounds and disease pathologies, thereby bridging the "translational gap" between animal studies and human clinical trials.

Can you create a model for a specific mutation I'm interested in?

Absolutely. Our custom services can engineer specific mutations into healthy iPSC lines using CRISPR-Cas9 or develop new iPSC lines from your specific patient population.

Are these models suitable for High-Throughput Screening (HTS)?

Yes, our iPSC-derived cell models are produced with high lot-to-lot consistency and scalability, making them perfectly suited for automated HTS platforms.

Can I study neuroinflammation with these models?

Definitely. Our iPSC-derived microglia and astrocytes are ideal tools for investigating neuroinflammatory signaling pathways, cytokine release, and assessing the efficacy of anti-inflammatory compounds.

Can these models be used for biomarker discovery?

They are perfectly suited for it. By analyzing the secretome from our models (especially co-cultures), you can discover and validate novel secreted biomarkers released by specific cell types under pathological conditions.

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Amyotrophic Lateral Sclerosis (ALS) Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease where historical reliance on inadequate preclinical models has hindered progress. The modern scientific consensus confirms ALS is not just a motor neuron disorder but a complex disease driven by a toxic microenvironment of glial cells. To accelerate therapeutic development, researchers need models that recapitulate this non-cell-autonomous pathology. At Creative Biolabs, we harness induced pluripotent stem cell (iPSC) technology to provide advanced, patient-derived cell models, empowering you to de-risk and accelerate your drug discovery pipeline. Contact our scientific team today to learn how our advanced cellular models can drive your research forward.

Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.

Types of ALS Cell Models We Offer

To fully address the multi-faceted nature of ALS, we provide a comprehensive portfolio of iPSC-derived cell models.

Types	Description
iPSC-Derived Motor Neurons	As the primary cells affected in ALS, our motor neuron models are an essential tool for studying cell-autonomous disease mechanisms. We provide a comprehensive library of models derived from both familial ALS (fALS) patients, featuring key mutations like SOD1, C9orf72, TDP-43, and FUS, and sporadic ALS (sALS) patients from a diverse cohort. To ensure definitive and clean results, we also offer genetically-corrected isogenic controls.As the primary cells affected in ALS, our motor neuron models are an essential tool for studying cell-autonomous disease mechanisms. We provide a comprehensive library of models derived from both familial ALS (fALS) patients, featuring key mutations like SOD1, C9orf72, TDP-43, and FUS, and sporadic ALS (sALS) patients from a diverse cohort. To ensure definitive and clean results, we also offer genetically-corrected isogenic controls.
iPSC-Derived Glial Cells	Investigate the toxic microenvironment with our models of the key supporting cells that become dysfunctional in ALS. We offer patient-derived astrocytes to study glutamate excitotoxicity and toxic factor secretion, microglia to model the neuroinflammatory response and evaluate therapeutics, and oligodendrocytes to research the mechanisms of demyelination and metabolic failure.
Complex Co-Culture Systems	Utilize the most physiologically relevant platforms to study the non-cell-autonomous nature of ALS. Our offerings include neuron-astrocyte co-cultures designed to directly assess astrocyte-mediated toxicity on motor neurons, as well as more advanced multi-cellular systems that combine neurons, astrocytes, and microglia to model the complex cellular crosstalk of the neuro-immune axis.
Custom Model Generation	If your specific research needs are not met by our catalog, our team can create custom models for you, including engineering novel mutations or developing lines from specific patient populations.

Advantages

Bridge the Translational Gap

Conduct your research directly in human cells, mitigating risks from inter-species differences and significantly increasing the likelihood of your findings translating to the clinic.

Capture Authentic Disease Pathology

Our models recapitulate key ALS pathological hallmarks like protein aggregation, organelle dysfunction, neuroinflammation, and non-cell-autonomous toxicity, providing a platform to study true disease mechanisms.

Accelerate Your Research Timeline

Skip the months-long process of developing and validating cell models from scratch. We provide ready-to-use, fully characterized cells, allowing you to focus immediately on your core research questions.

De-risk Clinical Trials

Generate robust preclinical data with more predictive human models to make smarter decisions before investing in expensive clinical trials.

Highly Customizable

Beyond our catalog offerings, our expert team can partner with you to develop custom cell models tailored to your specific research needs, such as unique genetic mutations or cellular backgrounds.

Applications

Applications	Description
Mechanistic Pathology Studies	Dissect the specific roles of astrocytes, microglia, and other glial cells in neuroinflammation and neuronal death.
High-Throughput Drug Screening (HTS)	Rapidly screen compound libraries on patient-specific cellular platforms to identify novel drug candidates that rescue ALS-related phenotypes.
Candidate Efficacy and Toxicity Testing	Assess the therapeutic potential and potential toxicity of drug candidates in a human cellular context before advancing to animal models.
Biomarker Discovery and Validation	Identify and validate fluid-based biomarkers (e.g., CHIT1, YKL-40) released by specific cell types under pathological conditions.
Cell Therapy Development	Test the efficacy of mesenchymal stem cell (MSC) or iPSC-derived cell therapies in modulating immune responses and providing neurotrophic support.

A picture that presents the Transplantation of genetically corrected Induced pluripotent stem cells. (María José Castellanos-Montiel, et al., 2020) (OA Literature)

Fig.1 Proteins are encoded by amyotrophic lateral sclerosis (ALS)-related genes affecting cytoskeletal dynamics.¹

FAQs

Why are iPSC models superior to animal models for ALS research?
iPSC models use human cells, allowing them to better recapitulate human-specific genetic backgrounds and disease pathologies, thereby bridging the "translational gap" between animal studies and human clinical trials.
Can you create a model for a specific mutation I'm interested in?
Absolutely. Our custom services can engineer specific mutations into healthy iPSC lines using CRISPR-Cas9 or develop new iPSC lines from your specific patient population.
Are these models suitable for High-Throughput Screening (HTS)?
Yes, our iPSC-derived cell models are produced with high lot-to-lot consistency and scalability, making them perfectly suited for automated HTS platforms.
Can I study neuroinflammation with these models?
Definitely. Our iPSC-derived microglia and astrocytes are ideal tools for investigating neuroinflammatory signaling pathways, cytokine release, and assessing the efficacy of anti-inflammatory compounds.
Can these models be used for biomarker discovery?
They are perfectly suited for it. By analyzing the secretome from our models (especially co-cultures), you can discover and validate novel secreted biomarkers released by specific cell types under pathological conditions.

Stop relying on conventional models that fail to capture the complexity of human disease. It's time to harness the power of patient-specific iPSC technology to generate definitive data in a truly relevant biological context.

At Creative Biolabs, we are committed to providing you with the highest-quality, most physiologically relevant ALS cell models and support services. Whether you need a ready-to-use cell line from our catalog or a fully customized solution for your unique research question, our team of experts is here to help. Contact us today to explore how we can help you unravel the mysteries of ALS and accelerate the development of life-changing therapies.