How is the pricing for these models determined, especially for custom projects?

Pricing varies based on the model type, scale of the order, and the complexity of any custom work. We are committed to providing value and offering competitive pricing for both academic and commercial labs. The most effective way to get an accurate cost estimate is to request a formal quote, and our team will provide a detailed proposal with no obligation.

For a custom model project, what kind of data and milestones can we expect during the process?

Custom projects are managed with full transparency. You can expect a dedicated project manager, regular progress updates, and defined milestone reports, which may include data confirming gene editing, pluripotency analysis, and characterization of the final differentiated model. A comprehensive final report is always included. To see a sample project plan, please schedule a consultation with our team.

How do I place an order?

You can request a quote directly from this page or contact our sales department. We will guide you through the process.

Can you develop a cell model from a specific patient's cells?

Yes, through our custom services, we can generate iPSC lines from patient samples (fibroblasts or PBMCs) and differentiate them into the spinal cord cell type you require.

Can these cells be refrozen after thawing?

We generally do not recommend refreezing differentiated cells like neurons and astrocytes, as it can significantly impact their viability and performance.

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Syringomyelia Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

The formation of a fluid-filled cavity, or syrinx, within the spinal cord defines syringomyelia. This pathological cavitation instigates a cascade of progressive neuronal degradation, manifesting as severe and debilitating clinical sequelae. Elucidation of the intricate pathophysiology underlying this disorder is an imperative for developing effective therapeutics; a pursuit, however, historically constrained by the profound scarcity of in vitro systems capable of faithfully recapitulating the nuanced cellular dynamics of the human spinal cord under pathological stress.

To address this critical gap, Creative Biolabs offers a comprehensive portfolio of rigorously characterized cellular models for syringomyelia investigation. These platforms provide robust, physiologically relevant tools designed to dissect pathogenic mechanisms, enable high-throughput therapeutic screening, and ultimately accelerate the translation of fundamental discoveries into clinical applications. Accelerate your research program. Contact us to receive a detailed quote or to begin a custom model consultation with our specialists.

For a fast way to find what you're looking for, view our entire Product List.

Types

Creative Biolabs provides a selection of standard and custom models to fit your precise research needs.

Types	Description
Human iPSC-Derived Spinal Cord Motor Neurons	Ideal for studying neuronal vulnerability and testing neuroprotective strategies.
Human iPSC-Derived Astrocytes (Spinal Cord Lineage)	The premier choice for investigating reactive astrogliosis, inflammation, and neuron-glia interactions.
Human iPSC-Derived Ependymal Cells	Crucial for research into cerebrospinal fluid (CSF) dynamics and the integrity of the central canal lining.
Primary Rodent Spinal Cord Cells	Mixed glial and neuronal cultures from neonatal rat or mouse spinal cords for comparative studies.
Custom Co-Culture Systems	We can develop biologically relevant co-cultures (e.g., Neuron-Astrocyte) to model complex cell-cell interactions in the spinal cord.
Custom Model Development	Have a specific need? We can partner with you to develop custom models, including those from patient-derived iPSCs, to study specific mutations or disease backgrounds.

Advantages

Choosing Creative Biolabs provides your research with a distinct competitive edge. Our models are engineered to overcome the traditional hurdles of neurological disease research.

Unparalleled Clinical Relevance

Move beyond the limitations of animal models. Our primary human cells provide a direct window into human-specific biology, reducing the translational gap and increasing the likelihood that your findings will be relevant to patient pathology.

Mechanistic Clarity and Precision

Isolate variables with confidence. By studying cell types individually or in defined co-culture combinations, you can precisely dissect the contribution of each population to the overall disease process.

Accelerated Research Timelines

Drastically reduce the time from hypothesis to data. In vitro models enable rapid experiment setup and high-throughput screening, saving months or even years compared to animal studies.

Exceptional Reproducibility and Reliability

Build your research on a foundation of trust. Our rigorous quality control, lot-to-lot consistency, and detailed protocols minimize experimental variability, leading to more robust and publishable data.

Ethical and Cost-Effective Research

Align your work with the 3Rs principles (Replacement, Reduction, Refinement) by reducing reliance on animal testing. This ethical approach is also highly cost-effective, lowering expenses associated with animal procurement and husbandry.

Applications

Applications	Description
Dissecting Disease Pathogenesis	Investigate the core biological events driving syringomyelia. Use our models to map signaling pathways for neuronal apoptosis, elucidate the mechanisms of reactive astrogliosis, and study ependymal cell dysfunction in syrinx initiation.
Therapeutic Screening & Drug Discovery	Accelerate your search for novel treatments. Execute high-throughput screening to identify neuroprotective agents, perform high-content analysis on drugs modulating astrogliosis, and test the efficacy of biologics against inflammatory responses.
Modeling Biomechanical & Environmental Stress	Recreate the specific stressors of the syringomyelia microenvironment. Investigate cellular responses to fluid shear stress, analyze the impact of osmotic and hydrostatic pressure, and assess the breakdown of cellular junctions under physical strain.
Predictive Toxicology & Safety Assessment	De-risk your drug development pipeline. Assess candidate neurotoxicity on motor neurons, evaluate off-target effects on essential glial cells, and generate human-relevant safety data to support your Investigational New Drug (IND) applications.
Biomarker Discovery & Validation	Identify and validate molecular indicators of disease. Analyze the secretome of stressed cultures to discover novel biomarkers. You can also correlate their expression with specific cellular states found in patient samples.

A picture that presents the spinal cord illustrating the anatomical impact of syringomyelia. (Fadila, et al., 2025) (OA Literature)

Fig.1 Cross-sectional schematic of the spinal cord illustrating the anatomical impact of syringomyelia.¹

FAQs

How is the pricing for these models determined, especially for custom projects?
Pricing varies based on the model type, scale of the order, and the complexity of any custom work. We are committed to providing value and offering competitive pricing for both academic and commercial labs. The most effective way to get an accurate cost estimate is to request a formal quote, and our team will provide a detailed proposal with no obligation.
For a custom model project, what kind of data and milestones can we expect during the process?
Custom projects are managed with full transparency. You can expect a dedicated project manager, regular progress updates, and defined milestone reports, which may include data confirming gene editing, pluripotency analysis, and characterization of the final differentiated model. A comprehensive final report is always included. To see a sample project plan, please schedule a consultation with our team.
How do I place an order?
You can request a quote directly from this page or contact our sales department. We will guide you through the process.
Can you develop a cell model from a specific patient's cells?
Yes, through our custom services, we can generate iPSC lines from patient samples (fibroblasts or PBMCs) and differentiate them into the spinal cord cell type you require.
Can these cells be refrozen after thawing?
We generally do not recommend refreezing differentiated cells like neurons and astrocytes, as it can significantly impact their viability and performance.

Accelerate your neurological research with Creative Biolabs as your dedicated partner. Our portfolio of Syringomyelia Cell Model Products, backed by profound scientific expertise, delivers the critical tools you need to dissect disease mechanisms, pinpoint new therapeutic targets, and shorten your project timeline. Contact our scientific team today to discuss your specific needs, get expert advice on the best model for your application, or request a quote for your project.