Can these models be used to study the cognitive aspects of CBD?

Yes. Our cholinergic neuron models, derived to mimic the Nucleus Basalis of Meynert, are specifically designed to study the cellular underpinnings of the cholinergic deficit that predicts cognitive decline in CBD.

Are the cells genetically modified?

Our standard lines are not modified, providing a native genetic background. However, we offer custom gene editing services (e.g., CRISPR-Cas9) to introduce or correct specific mutations.

How do your models compare to animal models of CBD?

Our human iPSC-derived models offer a significant advantage by bypassing species-specific differences in tau biology and cellular function, providing a more direct and relevant system for studying human disease.

Why is modeling 4R tau uptake in astrocytes so important?

Groundbreaking research shows astrocytic pathology in CBD arises from the uptake of external 4R tau. Modeling this specific mechanism is crucial for understanding disease progression and developing astrocyte-targeted therapies.

What is the expected viability of the cells upon thawing?

We guarantee high post-thaw viability (typically >80%) when our recommended protocols are followed.

Online Inquiry

Corticobasal Degeneration (CBD) Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Corticobasal Degeneration (CBD) is a formidable neurodegenerative disease, a distinct 4R tauopathy characterized by a complex interplay of neuronal loss and glial pathology. Research into CBD has been hampered by the lack of models that faithfully recapitulate its unique cellular and molecular features. Standard cell lines and animal models often fail to replicate the specific astrocytic tau pathology or the intricate neuronal vulnerabilities seen in the human brain.

To accelerate the discovery of transformative therapies, Creative Biolabs has developed a suite of state-of-the-art Corticobasal Degeneration (CBD) cell models. Derived from human induced pluripotent stem cells (iPSCs), our models provide an unprecedented, physiologically relevant in vitro platform to investigate disease mechanisms and screen for novel therapeutic agents.

Propel your CBD research forward. Contact our specialists for a detailed consultation or to request a quote.

Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.

Types of Cell Models

Types	Description
Induced Pluripotent Stem Cells (iPSCs)	Patient-derived iPSCs serve as a renewable source for generating any neural cell type, carrying the specific genetic background of the CBD donor.
Cortical Neurons	Essential for studying neuronal Tau pathology, synaptic dysfunction, and cell death.
Astrocytes	Crucial for investigating the role of glial cells in neuroinflammation and the propagation of Tau pathology.
3D Organoids	We can generate complex, self-organizing brain organoids that offer a more advanced model of cellular interactions and network development.

Advantages of Our CBD Models

Unmatched Physiological Relevance

Unlike simplistic cell lines, our iPSC-derived models provide a superior human cellular environment. They accurately replicate key pathogenic events, such as the preferential uptake of 4R tau by astrocytes, that are missed in conventional systems.

Elucidate Complex Disease Mechanisms:

Investigate the specific contributions of different cell types to CBD pathogenesis. Ask critical questions: How does neuronal 4R tau spread to astrocytes? What is the role of the cholinergic system in cognitive decline? How does cellular stress impact glial pathology?

Accelerate Drug Discovery & Validation

Our highly-characterized, reproducible models provide the ideal platform for medium- to high-throughput screening of compounds aimed at preventing tau aggregation, protecting neurons, or modulating glial responses.

Focus on Your Research, Not on Model Development

Bypass the time-consuming and resource-intensive process of generating and validating iPSC-derived neural models from scratch. Our validated, ready-to-use products allow you to get to your critical experiments faster.

Expert-Driven & Data-Supported

Developed by leading neuroscientists, our products are supported by comprehensive data sheets and expert technical support to ensure your success.

Choose the gold standard in disease modeling to gain a competitive edge in your research.

Applications

Our CBD cell models are versatile tools for a wide range of research applications:

Applications	Description
Mechanistic Studies	Dissect the molecular pathways of tau aggregation, propagation, and toxicity in specific neuronal and glial populations.
Therapeutic Screening	Identify and validate small molecules, biologics, or ASO therapies that can modify the course of the disease.
Biomarker Discovery	Use model supernatants or cell lysates to identify novel soluble biomarkers associated with specific pathological events, such as NbM neuronal stress or astrocyte reactivity.
Target Identification & Validation	Confirm the role of novel genetic risk factors or potential drug targets in a human-specific context.
Comparative Pathology	Investigate the differential vulnerability of various CNS cell types to the toxic effects of 4R tau.

A picture that presents the Tau pathology across diseases. (Fiock, et al., 2023) (OA Literature)

Fig.1 Tau pathology across diseases.¹

FAQs

Can these models be used to study the cognitive aspects of CBD?
Yes. Our cholinergic neuron models, derived to mimic the Nucleus Basalis of Meynert, are specifically designed to study the cellular underpinnings of the cholinergic deficit that predicts cognitive decline in CBD.
Are the cells genetically modified?
Our standard lines are not modified, providing a native genetic background. However, we offer custom gene editing services (e.g., CRISPR-Cas9) to introduce or correct specific mutations.
How do your models compare to animal models of CBD?
Our human iPSC-derived models offer a significant advantage by bypassing species-specific differences in tau biology and cellular function, providing a more direct and relevant system for studying human disease.
Why is modeling 4R tau uptake in astrocytes so important?
Groundbreaking research shows astrocytic pathology in CBD arises from the uptake of external 4R tau. Modeling this specific mechanism is crucial for understanding disease progression and developing astrocyte-targeted therapies.
What is the expected viability of the cells upon thawing?
We guarantee high post-thaw viability (typically >80%) when our recommended protocols are followed.

Creative Biolabs provides a powerful, multi-faceted platform to accelerate research into Corticobasal Degeneration. By combining patient-derived cell models that offer unmatched physiological relevance with the cutting-edge efficiency of CRISPR-ready technology, we empower researchers to uncover novel disease mechanisms and discover the next generation of therapeutics. Our team of expert scientists is ready to discuss how our CBD cell models can advance your specific research project. Contact Our Team for More Information and to Discuss Your Project.