Autoimmune & Inflammatory Disease related Research Tools
Introduction
The central and peripheral nervous systems were once considered immune-privileged sanctuaries. Today, we know they are the battlegrounds for some of the most devastating autoimmune and inflammatory diseases. To pioneer new therapies for conditions like MS, GBS, and NMOSD, researchers need models that faithfully replicate the complex neuro-immune crosstalk at the heart of these pathologies.
At Creative Biolabs, we provide researchers with robust, physiologically relevant neural cell models essential for dissecting the complex mechanisms of autoimmune and inflammatory neurological disorders. Our products empower you to move your research forward by offering reliable tools to study disease pathogenesis, identify novel therapeutic targets, and conduct preclinical screening of drug candidates. We deliver well-characterized cells and comprehensive data to ensure the reproducibility and accuracy of your findings. Contact our specialists for a detailed discussion and quote on powering your neuroscience research with clinically relevant neural models.
Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.
Types of Neurological Autoimmune Disease Cell Models
We provide specialized, highly characterized cell models essential for dissecting the pathology of a wide range of neuro-autoimmune disorders:
| Types | Description |
|---|---|
| Multiple Sclerosis (MS) Cell Models | Investigate the complex interplay of immune-mediated demyelination, oligodendrocyte injury, and glial cell activation within the central nervous system to test novel neuroprotective and remyelinating therapies. |
| Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Cell Models | Model the chronic inflammatory assault on peripheral nerve myelin, focusing on Schwann cell pathology, macrophage infiltration, and resulting nerve conduction deficits. |
| Neuromyelitis Optica Spectrum Disorder (NMOSD) Cell Models | Dissect the specific astrocytopathy driven by aquaporin-4 (AQP4) antibodies, a key pathological feature that distinguishes NMOSD from MS and allows for targeted therapeutic screening. |
| Autoimmune Encephalitis Cell Models | Explore antibody-mediated neuronal dysfunction by targeting critical synaptic proteins like the NMDA receptor, providing a platform to understand the basis of severe neuropsychiatric symptoms and test immunomodulatory agents. |
| Guillain-Barré Syndrome (GBS) Cell Models | Replicate the acute, rapid-onset attack on the peripheral nervous system, often linked to molecular mimicry, to study the mechanisms of nerve damage and screen for treatments that can halt disease progression. |
| Autoimmune Uveitis Cell Models | Study the sight-threatening inflammation of the uvea by modeling the breakdown of the blood-retinal barrier, immune cell infiltration, and subsequent damage to photoreceptors and retinal ganglion cells. |
Advantages
Leverage a Predictive, Human-Centric Framework
Our donor-derived neural cells provide biologically faithful systems that offer crucial insights often lost in animal models, enabling more accurate target validation and clearer paths for preclinical development.
Generate Consistent, High-Quality Data
Rigorous QC and standardized manufacturing minimize lot-to-lot variability, ensuring the reproducibility needed for long-term studies, screening campaigns, and robust preclinical data packages.
Accelerate Timelines and Optimize Resources
Accelerate your research by eliminating the time-consuming bottlenecks of cell sourcing and validation. Our models arrive fully characterized and experiment-ready, so your team can proceed directly to core discovery.
Gain a True Scientific Partner
Our multidisciplinary team of neuroscientists and immunologists understands the complexities of neuro-autoimmunity modeling and provides expert consultation, from experimental design to data interpretation, to help you achieve your goals.
Key Applications: Powering Every Stage of Discovery
Our neural cell models are versatile tools designed to support your research from initial discovery through preclinical validation.
| Applications | Description |
|---|---|
| Target Identification and Validation | Utilize our human-centric models to identify novel therapeutic targets within specific neural and immune cell types and validate their role in disease pathology. |
| Compound Screening and Drug Discovery | Implement our robust, reproducible cell systems in high-throughput or high-content screening campaigns to efficiently assess the efficacy and potency of candidate compounds. |
| Mechanism of Action (MoA) Studies | Delve deep into the molecular pathways of disease. Our models provide a controlled environment to dissect complex neuro-immune interactions and understand precisely how your therapeutic intervention works. |
| Biomarker Discovery | Analyze cell secretomes and expression profiles from our models to identify potential biomarkers for patient stratification, disease progression, or therapeutic response. |
| Translational Safety and Toxicity Assessment | Evaluate potential neurotoxicity and off-target effects of your compounds in a relevant human system early in the development process, reducing the risk of late-stage failures. |
Fig.1 Autoimmune diseases of the CNS.1
FAQs
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What are the main differences between your primary neural cells and iPSC-derived models?
Primary cells are isolated directly from tissue and closely mimic the in vivo environment, making them excellent for studying authentic cellular responses. However, they have a limited lifespan. iPSC-derived models can be generated from patient-specific cells and provide a virtually unlimited supply of cells, which is ideal for large-scale screening and studying the genetic basis of diseases. We can help you decide which model is best for your specific research question. -
How do I know which cell model is right for my specific autoimmune disease research?
Our expert scientific team can guide you in selecting the most appropriate model based on your research goals, the specific disease you are studying, and your experimental setup. We encourage you to schedule a free consultation to discuss your project in detail. -
Do you offer custom cell line development?
Yes, in addition to our extensive catalog of cell products, we offer custom services, including the development of new iPSC lines from patient samples and the genetic modification of existing cell lines to meet your specific research needs. Please inquire to learn more about our custom service capabilities. -
What kind of technical support do you offer?
You receive comprehensive support from our Ph.D.-level neuroscientists, who can assist with everything from experimental design and protocol optimization to data interpretation. -
My target disease isn't on your list. Can you create a custom model?
Yes. Custom model development is a core part of our service. If you are studying a rare or emerging neuro-autoimmune disease, contact us to discuss how we can build a model for you.
In summary, Creative Biolabs is your dedicated partner for advancing research in autoimmune and inflammatory neurological disorders. Our diverse portfolio of high-quality neural cell products, backed by expert scientific support, provides the critical tools you need to unravel disease mechanisms and accelerate the development of novel therapies. Contact our team of specialists, who are ready to discuss your project and help you select the best products for your research needs.
Related Product Sections
For more categories of Autoimmune & Inflammatory Disease related Research Tools, please visit the following link:
Reference
- Bhagavati, Satyakam. "Autoimmune disorders of the nervous system: pathophysiology, clinical features, and therapy." Frontiers in neurology 12 (2021): 664664. DOI: 10.3389/fneur.2021.664664. Use under Open Access license CC BY 4.0, without modification.