Can your SCI models be customized for my specific research pathway?

Absolutely. We pride ourselves on collaboration. Beyond our standard models, our scientific team can work with you to design a custom model, such as incorporating a specific genetic mutation in the iPSCs or developing a unique co-culture system to investigate your specific pathway of interest. Let's discuss your project needs.

How do these in vitro models compare to traditional animal models for SCI research?

Our human in vitro models offer distinct advantages. They provide a human-specific biological context, eliminating concerns about interspecies differences. They also offer much higher throughput and reproducibility, making them ideal for large-scale screening and dose-response studies. They are best used as a complementary tool to refine hypotheses before moving into more complex, lower-throughput animal studies.

What kind of quality control data do you provide with each model?

Every batch of cells and assembled models comes with a comprehensive Certificate of Analysis. This document includes data on cell identity verification via marker expression, purity assessment by flow cytometry, post-thaw viability counts, and functional validation data, such as neurite outgrowth potential or specific cell-type reactivity.

What is the main benefit of using a co-culture model over a simple neuron monoculture?

While neuron monocultures are excellent for studying direct neuronal effects, SCI pathology is driven by complex cell-cell interactions. Our co-culture models (e.g., with astrocytes and microglia) recapitulate crucial aspects of the in vivo environment, such as glial scarring and neuroinflammation. This allows you to test how your compound performs in a more physiologically realistic context.

Are your models suitable for high-content imaging and analysis?

Yes, they are perfectly suited for it. Our models are provided in optically clear, imaging-compatible microplates. The robust and reproducible nature of the cultures provides an ideal substrate for automated microscopy and high-content analysis of morphological changes, protein expression, cell viability, and other key parameters.

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Spinal Cord Injury Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

The profound neurological deficits resulting from spinal cord injury (SCI) present a formidable therapeutic challenge. This challenge is rooted in a multifaceted secondary injury cascade—a deleterious sequence encompassing neuronal apoptosis, Wallerian degeneration, progressive demyelination, and the establishment of a chronic, non-permissive neuroinflammatory milieu. Consequently, elucidating these mechanisms and assessing therapeutic interventions necessitates in vitro platforms that faithfully recapitulate key aspects of human SCI pathology.

To address this critical need, Creative Biolabs provides a comprehensive portfolio of advanced cellular models derived from human induced pluripotent stem cells (iPSCs) and primary tissues, engineered to dissect the complexities of SCI. These systems furnish a biologically relevant, human-specific context, thereby circumventing the inherent limitations of interspecies translation associated with conventional animal models and enabling the generation of more predictive datasets for therapeutic discovery. Contact our specialists to discuss your project requirements and receive a customized quote to accelerate your SCI research.

For efficient navigation of our offerings, please consult the complete Product List.

Key Types

Types	Description
Neuronal Injury Models	These are pure neuronal cultures subjected to axotomy (mechanical scratch) to study axonal dieback and regeneration.
Glial Scar Formation Models	Astrocyte-neuron co-cultures that replicate the reactive gliosis and inhibitory barrier that forms after injury.
Neuroinflammation Models	These are tri-culture systems including neurons, astrocytes, and microglia to study inflammatory responses and test anti-inflammatory agents.
Demyelination/Remyelination Models	Co-cultures with oligodendrocytes to investigate damage to myelin sheaths and screen for compounds that promote remyelination.

Advantages

Partnering with Creative Biolabs provides a decisive advantage for your research programs by transforming how you approach the complexities of Spinal Cord Injury.

Enhanced Translational Fidelity

Transition from the limitations of animal models to a physiologically pertinent human system. Our iPSC-derived cells offer an unparalleled context for investigating SCI pathology, substantially increasing the clinical relevance and predictive power of your findings.

Superior Data Integrity & Reproducibility

Mitigate the risk of experimental variability that can compromise research outcomes. Each lot is produced under meticulous, stringently controlled conditions to ensure minimal batch-to-batch variation, delivering the consistency required for robust, longitudinal studies.

Expedited Research & Discovery

Circumvent the resource-intensive, time-consuming process of in-house cell line development and differentiation. Our cryopreserved, ready-to-plate models can eliminate months from your project timeline, enabling your team to proceed directly to critical experiments and hypothesis testing.

Advanced Pathophysiological Modeling

Deconstruct the complexity of the SCI niche in vitro. Our portfolio provides the essential cellular components—neurons, astrocytes, and microglia—to build sophisticated monoculture or co-culture systems, allowing for the precise interrogation of key pathological events like neuroinflammation and glial scar formation.

De-Risked Experimental Outcomes

Proceed with unwavering confidence in your cellular models. Every vial is supported by a comprehensive Certificate of Analysis detailing robust characterization and quality control data. This assurance of performance, backed by our expert scientific support, minimizes experimental uncertainty and protects your research investment.

Applications

Our SCI cell models are validated for a wide array of cutting-edge research applications:

Applications	Description
Drug Discovery & High-Throughput Screening (HTS)	Screen compound libraries to identify novel therapeutics that promote neuronal survival or axonal regeneration.
Neuroinflammation Studies	Investigate the roles of astrocytes and microglia in the inflammatory cascade following injury.
Axonal Growth & Inhibition Assays	Model the inhibitory environment of the glial scar and test strategies to overcome it.
Neurotoxicity & Safety Pharmacology	Assess the potential neurotoxic effects of new chemical entities on human spinal cord neurons.
Mechanistic Pathway Analysis	Dissect the molecular and cellular pathways underlying neuronal death, demyelination, and astrogliosis.
3D Bioprinting & Organoid Development	Use our high-quality cells as the foundational building blocks for next-generation 3D models of the spinal cord.

A picture that presents Spinal cord injury. (Anjum, et al., 2020) (OA Literature)

Fig.1 Spinal cord injury (SCI) (a) phases of SCI, (b) sub-classification of secondary injury depending on duration of injury and (c) pathophysiological events according to SCI phases.¹

FAQs

Can your SCI models be customized for my specific research pathway?
Absolutely. We pride ourselves on collaboration. Beyond our standard models, our scientific team can work with you to design a custom model, such as incorporating a specific genetic mutation in the iPSCs or developing a unique co-culture system to investigate your specific pathway of interest. Let's discuss your project needs.
How do these in vitro models compare to traditional animal models for SCI research?
Our human in vitro models offer distinct advantages. They provide a human-specific biological context, eliminating concerns about interspecies differences. They also offer much higher throughput and reproducibility, making them ideal for large-scale screening and dose-response studies. They are best used as a complementary tool to refine hypotheses before moving into more complex, lower-throughput animal studies.
What kind of quality control data do you provide with each model?
Every batch of cells and assembled models comes with a comprehensive Certificate of Analysis. This document includes data on cell identity verification via marker expression, purity assessment by flow cytometry, post-thaw viability counts, and functional validation data, such as neurite outgrowth potential or specific cell-type reactivity.
What is the main benefit of using a co-culture model over a simple neuron monoculture?
While neuron monocultures are excellent for studying direct neuronal effects, SCI pathology is driven by complex cell-cell interactions. Our co-culture models (e.g., with astrocytes and microglia) recapitulate crucial aspects of the in vivo environment, such as glial scarring and neuroinflammation. This allows you to test how your compound performs in a more physiologically realistic context.
Are your models suitable for high-content imaging and analysis?
Yes, they are perfectly suited for it. Our models are provided in optically clear, imaging-compatible microplates. The robust and reproducible nature of the cultures provides an ideal substrate for automated microscopy and high-content analysis of morphological changes, protein expression, cell viability, and other key parameters.

The mission of Creative Biolabs is to empower the scientific community in its efforts to develop therapies for spinal cord injury. We achieve this by supplying innovative, reliable, and clinically relevant cell models suitable for a range of applications, including high-throughput screening and detailed mechanistic investigations, all backed by our expert support to facilitate your project's success. Our team of expert scientists is ready to discuss your project and help you choose the right solution. Reach out to us for technical information, quotes, or to schedule a consultation.