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Neuronal Marker Antibody Preparation Service
Introduction
Creative Biolabs' Neuronal Marker Antibody Preparation Service provides specialized, high-specificity antibodies for nervous system research, supporting validation of cellular architecture, stromal health, and molecular landscapes required by modern high-impact studies.
The service leverages advanced phage display and hybridoma platforms to deliver high-affinity, validated antibodies, enabling precise identification of neuronal subpopulations, glial cells, and stromal niches, as well as clear visualization of protein co-localization and synaptic connections for impactful research and clinical transition.
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Neuronal Marker Antibody Preparation Service
We offer customized development and production of highly specific antibodies against neuronal biomarkers, supporting precise identification, localization, and quantitative analysis of neurons and related structures in nervous system research.
Key Advantages
- High specificity and low cross-reactivity with validated performance
- Flexible formats, including polyclonal and monoclonal antibodies
- Multiple conjugates available for immunofluorescence, IHC, and Western blot
- Strict quality control to ensure batch-to-batch consistency
- Custom epitope design and species cross-reactivity optimization
Common Markers
| Category | Core Research Applications | Representative Markers |
|---|---|---|
| Neurodegenerative Disease Targets | Studies of Alzheimer's disease, Parkinson's disease, ALS, multiple sclerosis, Huntington's disease, etc. | Aβ, C9orf72, HTT, IL-17A, α-Synuclein, Tau, Parkin, LRRK2, MBP |
| Neuronal Markers | Identification of neurons and subtypes, including dopaminergic, glutamatergic, and motor neurons | ChAT, OTX2, GAD65, NMDAR2B, ISL2, Calretinin |
| Glial Progenitor Cell Markers | Identification and differentiation research of glial progenitor cells | A2B5, CD44 |
| Presynaptic & Postsynaptic Markers | Labeling of synaptic structures and analysis of neurotransmission functions | HOMER1, PSD95, Synapsin, Synaptotagmin, VGLUT1 |
| Oligodendrocyte Precursor & Oligodendrocyte Markers | Myelination, differentiation, and functional research of oligodendrocytes | NG2, OLIG1, OLIG2, PDGFRA, MBP, GalC |
| Neuroectodermal Markers | Early neurogenesis, neural plate, and neural tube development | NCAM, SOX2, OTX2, PAX3, PAX6 |
| Neural Stem Cell Markers | Identification, stemness, and differentiation research of neural stem cells | SOX1, SOX2, PAX3, PAX6, FOXG1, Nestin |
| Astrocyte Markers | Identification and functional research of astrocytes | ALDH1L1, EAAT2, GFAP, Glutamine Synthetase, S100β |
| Microglial Markers | Microglial activation, central immune and phagocytic functions | CD11b, CD68, CX3CR1, HLA-DR, IBA1 |
Applications
- Immunohistochemistry (IHC) and immunofluorescence (IF) imaging
- Western blot, ELISA, and flow cytometry analysis
- Neuronal identification, counting, and morphological analysis
- Identification of neuronal subtypes and synaptic structure labeling
- Validation of neural development, injury, and disease models
Workflow
Our service is designed to be full-scale and detailed, ensuring that potential clients understand every stage of the antibody development lifecycle.
What We Can Offer
As a global leader in high-performance reagent development, Creative Biolabs provides a sophisticated suite of advantages tailored specifically for the Neuronal Marker Antibody Preparation Service. We offer a seamless transition from initial antigen discovery to industrial-scale production, ensuring your neuro-regenerative projects are backed by unmatched technical depth.
Full-scale Development Track
One-stop antibody service from initial epitope mapping and library construction to pilot-scale and large-scale recombinant production.
Advanced Engineering Platforms
Optimized codon usage and protein engineering to maximize expression and stability in various mammalian and microbial systems.
Massive Library Capability
Access to diverse phage display libraries with over 1010 independent clones, ensuring the discovery of rare, high-affinity binders for difficult neural targets.
Rigorous Quality Framework
Well-established quality systems incorporating Quality-by-Design (QbD) and Process Analytical Techniques (PAT) to guarantee batch-to-batch reproducibility.
Precision Validation Tools
Integration of High-Hazard Analysis and Critical Control Point (HACCP) principles alongside GMP-certified production for clinical-grade diagnostic applications.
Customized Solution Architecture
Every project is assigned a dedicated scientific consultant to ensure the resulting markers are specifically optimized for your unique tissue models, species, and detection platforms.
High-Standard Analytics
Utilization of advanced biophysical characterization tools to quantify and evaluate antibody kinetics and thermodynamic stability.
Case Study
This study performed immunohistochemical assays using AT8 antibody against phosphorylated tau to investigate the relationship between pTau accumulation and neuronal vulnerability.
AD samples were divided into early and late Braak stages. The total AT8+ pTau level and the proportion of pTau-positive neurons were measured, and the percentage of pTau+ cells in each neuronal subtype was quantified.
The results showed that pTau increased with AD progression and preferentially accumulated in RORB+GPC5+ neurons. However, the density of these neurons did not decline in AD, indicating that intracellular AT8+ pTau accumulation is not a major determinant of neuronal loss.
Fig.1 Intracellular accumulation of AT8+ pTau and 4G8+ Aβ (intraAβ) in neuronal subtypes.1
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FAQs
Q: How do you ensure the antibody won't cross-react with similar proteins?
A: We use advanced bioinformatic modeling during the antigen design phase to exclude sequences shared by homologous proteins, followed by negative screening against related antigens.
Q: Can these antibodies be used for in vivo tracking?
A: Yes, we offer specialized labeling services (e.g., fluorophores or gold nanoparticles) and can produce low-endotoxin formats suitable for functional in vivo studies.
Q: What happens if my target protein has low immunogenicity?
A: We employ proprietary adjuvant systems and carrier protein conjugation (such as KLH or BSA) to boost the immune response and ensure successful antibody generation.
Q: Do you offer validation on specific tissue types, like human brain sections?
A: Absolutely. We can perform custom immunostaining on a variety of tissue types provided by the client or sourced from our biological bank to ensure the antibody performs in your specific context.
Q: How does this service compare to buying commercial "off-the-shelf" antibodies?
A: Commercial antibodies are often mass-produced for general use. Our custom service ensures the antibody is optimized for your specific epitope, species, and application, which is critical for novel or difficult targets.
Creative Biolabs offers a world-class Neuronal Marker Antibody Preparation Service that bridges the gap between theoretical research and empirical validation. From mapping the aging thymus to verifying the success of ectopic organogenesis in lymph nodes, our antibodies provide the precision required for the next generation of regenerative medicine.
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Reference
- Caramello, Alessia, et al. "Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer's disease." Nature Communications 16.1 (2025): 5189. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.1038/s41467-025-60328-w.
For Research Use Only. Not For Clinical Use.