Neurodegenerative Disease related Research Tools
Introduction
The path to a successful neurodegenerative disease therapeutic is challenging. For decades, researchers have been hindered by preclinical models that fail to capture the complex, human-specific pathology of diseases like Alzheimer's, Parkinson's, and ALS. This "translational gap" is a primary reason why over 99% of drug candidates fail in clinical trials, resulting in enormous costs and lost time.
At Creative Biolabs, we bridge that gap. We have moved beyond the limitations of traditional models by developing a comprehensive portfolio of high-fidelity, iPSC-derived neural cell products. Our models provide an unprecedented window into human neurobiology, enabling you to test your therapeutic strategies in a system that truly reflects the patient's condition. Partner with our specialists to accelerate your next breakthrough. Inquire Now & Get a Quote.
Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.
Types of Our Cell Models for Neurodegenerative Diseases
| Types | Description |
|---|---|
| Alzheimer's Disease (AD) Models | Move beyond the limitations of animal models with our 3D cerebral organoid systems that spontaneously develop both amyloid-β plaques and hyperphosphorylated, aggregated tau—the two core pathologies of AD. These models are ideal for testing the efficacy of anti-amyloid or anti-tau therapeutics. |
| Parkinson's Disease (PD) Models | Investigate the progressive loss of dopaminergic neurons using our precisely differentiated midbrain neuron cultures. We offer models derived from patients with sporadic PD or specific genetic mutations (e.g., LRRK2, SNCA) to test neuroprotective compounds and understand cell-type-specific vulnerability. |
| ALS & Motor Neuron Disease Models | Dissect the mechanisms of motor neuron death with our iPSC-derived spinal motor neuron cultures. We can establish co-cultures with astrocytes and microglia to model non-cell-autonomous toxicity and investigate the role of neuroinflammation in disease progression. |
| Models for Huntington's, FTD, and More | Our flexible iPSC platform allows us to develop bespoke models for a wide range of other neurodegenerative conditions, including those associated with polyglutamine repeat expansions (Huntington's) or specific proteinopathies (FTD). |
Advantages: Gain a Decisive Preclinical Edge
Choosing Creative Biolabs' neural models gives your research program a powerful competitive advantage, translating directly into more confident decision-making.
Unprecedented Physiological Relevance
Our 3D models bridge the gap between animal and human studies by preserving authentic cellular interactions and recreating the multicellular involvement that characterizes neurodegenerative diseases.
Modeling of Human-Specific Pathology
Our systems successfully recapitulate complex disease hallmarks not seen in other models, such as the aggregation of α-synuclein in PD models and the simultaneous formation of amyloid-β plaques and neurofibrillary tangles (NFTs) in AD models.
Patient-Specific & Sporadic Disease Modeling
Using iPSCs derived from any individual, we create models with a patient's specific genetic variants. This is invaluable for studying both familial and sporadic (idiopathic) forms of diseases like PD.
Dissecting Complex Cellular Mechanisms
Our models enable investigating disease mechanisms by dissecting each cell's contribution to pathology. Study how astrocytes become toxic to motor neurons, how microglia spread pathological molecules, and identify vulnerable versus resilient dopaminergic neuron subtypes in PD.
A Robust Platform for Target Validation and Screening:
Our human-relevant systems are suitable for target validation and, because they are derived from scalable hPSC sources, they are ideal for high-throughput drug screening.
Enhanced Complexity with Vascular and Immune Components
We can incorporate iPSC-derived vascular cells and microglia into our neural organoids , enabling the creation of more complex in vitro constructs to study neurovascular and neuroimmune interactions.
Applications: Powering Every Stage of Drug Discovery
Our human neural models are versatile platforms that can be seamlessly integrated into your research and development workflow to address key preclinical questions.
| Applications | Description |
|---|---|
| Drug Discovery & High-Throughput Screening (HTS) | Our robust and reproducible 2D cell cultures are optimized for HTS and high-content imaging, allowing you to efficiently screen large compound libraries for disease-modifying effects. |
| Target Identification and Validation | Use our patient-derived models featuring specific genetic backgrounds to confirm the role of a particular gene or pathway in the disease process, validating your therapeutic target in a relevant human system. |
| Neurotoxicity and Safety Assessment | Evaluate the potential neurotoxic effects of your lead compounds early in development. By testing on human neurons and glia, you can identify safety liabilities before committing to costly in vivo studies. |
| Personalized Medicine Approaches | Assess differential drug responses across cell lines derived from various patients. This can help stratify patient populations and identify biomarkers that predict therapeutic response, paving the way for more personalized treatment strategies. |
Fig.1 An illustration depicting a range of pathological tau lesions in different cell types in tauopathies.1
FAQs
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What are iPSC-derived neural models?
They are specialized human brain cells (like neurons, astrocytes, etc.) grown in the lab from induced pluripotent stem cells (iPSCs). iPSCs are created by reprogramming adult cells (like skin or blood cells), providing a renewable source for any cell type in the body, all with a human genetic background. -
What specific neurodegenerative diseases can you model?
Our platforms are adaptable for a wide range of conditions, including Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Huntington's Disease, and Multiple Sclerosis (MS). -
Can you create models from patients with specific mutations?
Absolutely. This is one of our core strengths. We can develop cell lines from patients carrying specific disease-relevant mutations (e.g., APOE4, LRRK2, SNCA, C9orf72), creating a powerful tool for studying genetic influence and testing targeted therapies. -
What specific cell types can I order?
Our catalog includes, but is not limited to: Cortical Neurons (Glutamatergic), GABAergic Interneurons, Midbrain Dopaminergic Neurons, Spinal Motor Neurons, Astrocytes, Oligodendrocytes, Microglia. -
Can I use these models to study synaptic function?
Yes. Our neuronal cultures form functional synaptic connections. We can support assays like calcium imaging and multi-electrode array (MEA) recordings to assess synaptic activity and network function in response to your compounds.
Creative Biolabs is dedicated to providing the most advanced, physiologically relevant human cell models and therapeutic products to the neuroscience community. We combine cutting-edge science with a rigorous focus on quality to help our partners overcome the critical hurdles in neurotherapeutic development. Our team of expert scientists is ready to discuss your project needs and design a solution tailored to your goals. Contact Our Team for More Information and to Discuss Your Project.
Related Product Sections
For more categories of Neurodegenerative Disease related Research Tools, please visit the following link:
Reference
- Chung, Dah-eun Chloe, et al. "Cellular and pathological heterogeneity of primary tauopathies." Molecular neurodegeneration 16 (2021): 1-20. DOI: 10.1186/s13024-021-00476-x. Use under Open Access license CC BY 4.0, without modification.