Are these models suitable for high-throughput screening (HTS)?

Yes, their high purity, viability, and lot-to-lot consistency make them an excellent choice for HTS applications in 96-well or 384-well formats.

Do you provide technical support?

Absolutely. Our team of PhD-level scientists is available to assist you with any questions regarding handling, culturing, and application of our products.

Can these models be customized for my specific research focus?

Absolutely. We encourage you to discuss your unique project needs with our scientific team. We can often tailor aspects of the model, such as the specific inflammatory stimulus or co-culture components, to better align with your research questions. Our team is ready to hear about your project. Let's connect.

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Bell's Palsy Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

For researchers investigating neurological disorders, conditions with unknown etiologies like Bell's palsy present a formidable challenge. To help you move beyond the limitations of current corticosteroid treatments and pioneer targeted therapies, Creative Biolabs provides sophisticated, physiologically relevant preclinical models. Our tools are designed to empower your work in deciphering the complexities of this sudden facial paralysis.

Traditional approaches have been limited, hindering the investigation of the core mechanisms believed to be at play: viral-induced inflammation, demyelination of the facial nerve (Cranial Nerve VII), and nerve compression. Creative Biolabs bridges this critical gap by providing a comprehensive portfolio of highly characterized and validated human cell models specifically curated for Bell's palsy research. Our products move your research beyond the limitations of animal models, offering a direct window into human-specific cellular pathology and providing a robust platform for drug discovery.

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Types

We offer a multi-faceted portfolio of primary cells, iPSC-derived models, and innovative co-culture systems, giving you the flexibility to choose the perfect model for your specific research question.

Types	Description
Primary Human Schwann Cells (HSCs)	Schwann cells are the glial cells responsible for creating and maintaining the protective myelin sheath around peripheral nerves, including the facial nerve. In Bell's palsy, these crucial cells are at the center of the pathology; inflammation makes them both the primary targets of damage and the frontline defenders of the nerve, leading to the characteristic demyelination.
iPSC-Derived Human Peripheral Neurons	For your research on nerve damage and regeneration, our iPSC-derived peripheral neurons provide a consistent, reliable, and ethically sourced alternative to primary neurons. This unparalleled solution ensures batch-to-batch reproducibility, free from the availability limitations of traditional sources.
Neuron & Schwann Cell Co-Culture System	To advance your research on nerve health, modeling the interaction between neurons and Schwann cells is essential. Our ready-to-use co-culture system provides you with a powerful platform to achieve this, enabling detailed study of the complex dynamics of myelination and demyelination in a controlled setting.
Bell's Palsy "Disease-in-a-Dish" Models	Select the ideal model for your study: our Schwann cells or co-culture systems can be delivered pre-treated. Choose a potent inflammatory cocktail (like TNF-α and IL-1β) or a viral mimic (poly(I:C)) to induce a strong inflammatory and demyelinating phenotype right out of the box.

Advantages

By integrating Creative Biolabs' Bell's Palsy models into your studies, you gain a distinct competitive advantage.

Unmatched Physiological Relevance

Move beyond the limitations of animal models and generic cell lines. Our human-derived systems capture species-specific cellular responses essential for studying inflammation, demyelination, and neuroprotection.

Exceptional Reproducibility

Standardized protocols and stringent QC eliminate the variability associated with primary tissue, ensuring consistent, publication-quality data across experiments.

Accelerate Your Research Pipeline

Skip months of cell line development and optimization. Our ready-to-use models allow you to focus immediately on critical research questions.

Ideal Platform for Screening

The scalability and consistency of our models make them perfectly suited for high-throughput screening (HTS) of novel therapeutic compounds.

Drive Mechanistic Discovery

Create controlled in vitro environments to investigate the specific roles of viral infection (e.g., HSV-1), inflammation, and ischemia in the onset of facial nerve paralysis.

Applications

Our Bell's Palsy cell models are versatile tools designed to support a wide range of research applications:

Applications	Description
Pathophysiology Studies	Investigate the molecular and cellular mechanisms underlying nerve inflammation, compression, and demyelination.
Therapeutic Efficacy Screening	Test novel anti-inflammatory agents, antiviral compounds, neuroprotective molecules, and regenerative therapies.
Neurotoxicity Assessment	Evaluate the potential toxic effects of drug candidates on facial motor neurons and Schwann cells.
Viral Pathogenesis Modeling	Co-culture models can be used to study the reactivation and impact of latent viruses like HSV-1 and VZV on nerve function.
Biomarker Discovery & Validation	Identify and validate novel biomarkers for diagnosis, prognosis, or therapeutic response in a controlled human cell system.
Gene Function Analysis	Utilize tools like CRISPR/Cas9 or siRNA to study the function of specific genes in the context of Bell's Palsy.

A picture that presents A summary of the pathophysiology involved in ischemic Bell's Palsy. (Maida, et al., 2024) (OA Literature)

Fig.1 Proposed mechanism of facial palsy induction by deep lip HSV-1 infection.¹

FAQs

Are these models suitable for high-throughput screening (HTS)?
Yes, their high purity, viability, and lot-to-lot consistency make them an excellent choice for HTS applications in 96-well or 384-well formats.
Do you provide technical support?
Absolutely. Our team of PhD-level scientists is available to assist you with any questions regarding handling, culturing, and application of our products.
Can these models be customized for my specific research focus?
Absolutely. We encourage you to discuss your unique project needs with our scientific team. We can often tailor aspects of the model, such as the specific inflammatory stimulus or co-culture components, to better align with your research questions. Our team is ready to hear about your project. Let's connect.

At Creative Biolabs, we are dedicated to equipping you with the highest quality tools for complex disease research. Our Bell's Palsy Cell Models empower confident, high-impact science—from investigating novel hypotheses to screening for effective therapeutics. Let our technology accelerate your next breakthrough. Contact us today to discuss your project or to request pricing information.