How do these models help study SPS?

They provide a consistent and controlled system to investigate what goes wrong at a cellular level, test how potential drugs might work, and understand the role of specific autoantibodies without the complexities of animal models.

Can I use these models to test immunotherapies like IVIg?

Absolutely. Our models are ideal for setting up co-culture assays to study the effects of immunotherapies on antibody-mediated damage or to screen for new immunomodulatory compounds.

My research focuses on paraneoplastic SPS. Do you have relevant models?

Yes. We offer models that express antigens like amphiphysin, which are specifically associated with paraneoplastic variants of SPS.

What's the difference between a GAD65 model and a GlyR model?

They represent different subtypes of the SPS spectrum. GAD65 is the most common target in SPS. The Glycine Receptor (GlyR) is another important target found in a subset of patients, often associated with a distinct clinical presentation.

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Stiff Person Syndrome (SPS) Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Stiff Person Syndrome (SPS) is a complex autoimmune neurological disorder, and unlocking its mechanisms is key to developing new therapies. Research progress depends on having access to biologically relevant, reliable laboratory models.

At Creative Biolabs, we specialize in developing physiologically relevant cell models that empower researchers to explore the pathophysiology of SPS with greater precision. Our suite of SPS cell models provides the robust tools you need to investigate GABAergic neurotransmission, screen novel immunotherapies, and push the boundaries of neurological science. Contact our team of scientific experts to begin a dialogue about your unique project. Whether you have a fully-formed research plan or an early-stage concept, share your objectives with us. We will collaborate with you to design a tailored experimental strategy and provide a comprehensive proposal that includes a detailed scope, timeline, and transparent pricing.

For a detailed enumeration of our specific offerings, please consult our comprehensive Product List.

Available Model Types

We offer a tiered selection of models to meet every research need and budget.

Types	Description
GAD65-Expressing Neuronal Lines	Engineered cell lines that stably overexpress glutamic acid decarboxylase 65 (GAD65), the primary autoantigen in classic SPS.
GABAergic Neuron Models	Models designed to replicate the impaired inhibitory GABAergic neurotransmission central to SPS pathology.
Glycine Receptor (GlyR) Mutant Models	Cell lines incorporating mutations or antibody targets in the glycine-alpha 1 receptor, relevant for SPS variants.
Paraneoplastic Antigen Models	Models expressing antigens like amphiphysin, crucial for studying paraneoplastic SPS associated with certain cancers.
Custom iPSC-Derived Neurons	Development of patient-specific iPSC lines that can be differentiated into GABAergic neurons or other relevant cell types, offering a powerful tool for personalized medicine research.

The Creative Biolabs Advantage

Choosing our SPS cell models gives your research a significant edge.

Accelerate Discovery

Bypass the time-consuming and costly process of developing models from scratch. Our validated, off-the-shelf and custom models let you focus on your primary research questions.

Enhance Clinical Relevance

By mirroring the impaired GABAergic pathways and autoimmune targets seen in patients, our models provide more predictive data for therapeutic development.

Improve Data Consistency

Reduce experimental variability with highly characterized and standardized cell lines, leading to more reliable and publishable results.

Access Unmatched Expertise

Leverage our two decades of experience in complex cell model development. Our scientific team is available to provide support and help you select the perfect model for your study.

Applications for Research & Drug Discovery

Our SPS cell models are versatile tools suitable for a wide range of applications:

Applications	Description
High-Throughput Drug Screening	Efficiently screen compound libraries to identify novel GABA-enhancing agents or senomorphics.
Immunotherapy Efficacy Testing	Evaluate the mechanism of action and efficacy of potential immunotherapies like IVIg, rituximab, and next-generation anti-B-cell agents.
Pathophysiology Studies	Investigate the functional consequences of anti-GAD and other autoantibodies on neuronal health and GABAergic signaling.
Biomarker Discovery	Use models to identify new diagnostic or prognostic biomarkers associated with SPS disease progression.
Toxicity and Safety Profiling	Assess the potential neurotoxicity of drug candidates in a relevant biological context.

A picture that presents Immunopathology of classical SPS and the postulated mechanisms of ECP. (Castillo-Aleman, et al., 2024) (OA Literature)

Fig.1 Immunopathology of classical SPS and the postulated mechanisms of ECP.¹

FAQs

How do these models help study SPS?
They provide a consistent and controlled system to investigate what goes wrong at a cellular level, test how potential drugs might work, and understand the role of specific autoantibodies without the complexities of animal models.
Can I use these models to test immunotherapies like IVIg?
Absolutely. Our models are ideal for setting up co-culture assays to study the effects of immunotherapies on antibody-mediated damage or to screen for new immunomodulatory compounds.
My research focuses on paraneoplastic SPS. Do you have relevant models?
Yes. We offer models that express antigens like amphiphysin, which are specifically associated with paraneoplastic variants of SPS.
What's the difference between a GAD65 model and a GlyR model?
They represent different subtypes of the SPS spectrum. GAD65 is the most common target in SPS. The Glycine Receptor (GlyR) is another important target found in a subset of patients, often associated with a distinct clinical presentation.

At Creative Biolabs, we are committed to providing the scientific community with the highest quality tools and services. Our Stiff Person Syndrome cell models are developed and validated by leading scientists to ensure you get reliable, reproducible, and translatable data. Move your research forward with confidence.

Contact us today to discuss your project with one of our specialists and learn how our advanced SPS models can help you achieve your research goals.