How well do the cells typically survive the thawing process?

We guarantee high post-thaw viability, typically >80-90%, when our recommended thawing protocols are followed.

Can I use these cells for long-term culture?

Our primary cells are designed for acute to mid-term experiments. For long-term studies, our iPSC-derived models are often more suitable. For guidance on your specific application, we invite you to speak with our technical team.

Can you develop a custom MS cell model for my project?

Yes, we have a dedicated team for custom service projects. We can develop unique co-culture configurations or iPSC-derived models based on your specific research requirements.

How do your iPSC-derived models compare to primary cells for MS research?

Both have unique advantages! Primary cells offer a model that is closest to the in vivo state. iPSC-derived models provide an inexhaustible resource, enable patient-specific studies, and are ideal for large-scale screenings where consistency is key. We can help you decide which model is best suited for your specific research question.

Do you offer support if we encounter issues with culturing the cells?

Yes, our commitment to your success continues after purchase. Our team of PhD-level scientists is available to provide expert technical support. If you have any questions about handling, culturing, or assaying our cells, we encourage you to reach out so we can help you get the best results.

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Multiple Sclerosis (MS) Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Unraveling the complex pathology of Multiple Sclerosis (MS)—from neuroinflammation and demyelination to remyelination failure—requires sophisticated and reliable research models. At Creative Biolabs, we specialize in developing high-fidelity MS cell models that empower researchers to move beyond these limitations. Our robust, well-characterized cellular systems provide the predictive power and reproducibility you need to accelerate your therapeutic pipeline, from target validation to preclinical screening. Contact our MS Model Specialists to discuss how our advanced in vitro models can bring clarity to your research and to receive a quote today.

Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.

Types of MS Cell Models Offered

We provide a comprehensive selection of mono- and co-culture models critical for studying MS.

Types	Description
iPSC-Derived CNS Cells	We offer patient-specific oligodendrocytes, astrocytes, and microglia derived from iPSCs of donors with various forms of MS. This model provides an excellent system for both studying the triggers of demyelination and screening for novel remyelinating agents.
Primary Human Oligodendrocytes & OPCs	The central players in myelin health and disease. An optimal platform for elucidating the mechanisms of demyelination and for screening potential remyelinating therapeutics.
Primary Human Astrocytes	Essential for investigating the blood-brain barrier, glial scar formation, and the complex inflammatory signaling cascades in MS.
Primary Human Microglia	The resident immune cells of the CNS. Critical for modeling neuroinflammatory processes and screening anti-inflammatory compounds.
Neuron and Glial Co-cultures	Sophisticated systems to study the complex interplay between neurons and glial cells during injury, inflammation, and repair.
Gene-Edited Cell Models	Utilizing cutting-edge technologies like CRISPR-Cas9, we provide cell models with specific gene knockouts (e.g., MS risk genes like IL7R), knock-ins, or point mutations in any relevant cell type. These precision models are powerful tools for validating targets and dissecting the function of specific genes in MS pathogenesis.

Your Advantages: Accelerate Your Breakthroughs

Partnering with Creative Biolabs translates directly to more efficient and impactful research.

Generate More Predictive Data

Work with models that accurately reflect human MS pathology, increasing the clinical relevance of your findings and reducing late-stage failures.

Ensure Reproducible Results

Depend on our stringent quality control and consistent performance to build confidence in your data and publish with certainty.

Accelerate Your Research Timeline

Bypass the lengthy and resource-intensive process of model development. Our ready-to-use cells allow your team to focus on core experimental questions.

Save Valuable Time and Resources:

Reduce internal costs associated with cell sourcing, characterization, and quality control. We've done the foundational work for you.

Partner with MS Modeling Experts

Gain access to our Ph.D.-level scientific support team to help you select the optimal model and troubleshoot your experiments.

Key Applications

Our MS cell models are engineered to support the entire drug discovery and development workflow.

Applications	Description
High-Throughput Drug Screening	Efficiently screen compound libraries for efficacy in promoting remyelination or reducing inflammation.
Mechanism of Action (MoA) Studies	Elucidate the specific cellular and molecular pathways targeted by your lead candidates.
Target Identification and Validation	Confirm the role of novel genetic or protein targets in MS-relevant cell types.
Neuroinflammation and Demyelination Assays	Model key disease events, such as astrocyte activation, microglial polarization, and oligodendrocyte injury.
Remyelination Therapeutic Assessment	Directly measure the potential of new therapies to induce oligodendrocyte precursor cell (OPC) differentiation and myelin formation.
Neurotoxicity and Safety Profiling	Evaluate the off-target effects of compounds on individual CNS cell types.

A picture that presents the Crossing of the Blood-Brain Barrier by Immune Cells in Multiple Sclerosis. (Patil, et al., 2024) (OA Literature)

Fig.1 Transmigration of immune cells across the blood–brain barrier in multiple sclerosis.¹

FAQs

How well do the cells typically survive the thawing process?
We guarantee high post-thaw viability, typically >80-90%, when our recommended thawing protocols are followed.
Can I use these cells for long-term culture?
Our primary cells are designed for acute to mid-term experiments. For long-term studies, our iPSC-derived models are often more suitable. For guidance on your specific application, we invite you to speak with our technical team.
Can you develop a custom MS cell model for my project?
Yes, we have a dedicated team for custom service projects. We can develop unique co-culture configurations or iPSC-derived models based on your specific research requirements.
How do your iPSC-derived models compare to primary cells for MS research?
Both have unique advantages! Primary cells offer a model that is closest to the in vivo state. iPSC-derived models provide an inexhaustible resource, enable patient-specific studies, and are ideal for large-scale screenings where consistency is key. We can help you decide which model is best suited for your specific research question.
Do you offer support if we encounter issues with culturing the cells?
Yes, our commitment to your success continues after purchase. Our team of PhD-level scientists is available to provide expert technical support. If you have any questions about handling, culturing, or assaying our cells, we encourage you to reach out so we can help you get the best results.

Creative Biolabs is your dedicated partner for advancing Multiple Sclerosis research. We provide high-quality, functionally relevant, and rigorously validated cell models essential for dissecting disease mechanisms and discovering next-generation therapeutics. Our products are designed to deliver consistency and reliability, helping you achieve your research milestones faster. Contact us for a quote, to discuss your project, or to learn more about our entire portfolio of solutions.