What makes your cell models specific for migraine research?

Our models are primarily derived from trigeminal ganglion neurons, the key cell type that initiates migraine pain signaling. We've optimized them to express high levels of CGRP and other relevant targets and validated their functional response to stimuli known to trigger migraine-like events, making them highly specific and relevant.

Can we use these models to test our specific class of compounds, like antibodies or biologics?

Absolutely. The models are versatile and have been successfully used to test small molecules, peptides, and monoclonal antibodies. The best approach depends on your target. We encourage you to schedule a brief consultation with our scientists to discuss your compound and design the most effective experiment.

Can I use these models for CGRP release assays?

Absolutely. Our CGRP Overexpressing TG Neuron Line is specifically optimized for this application, providing a robust and reproducible signal window.

Can you create a custom model for a target you don't list?

Yes, we offer custom cell line engineering services. Contact our scientific team to discuss your project requirements.

Are the cells human or rodent-derived?

We offer models from both human and rodent (rat, mouse) origins to support a wide range of research and translational studies. Please check the specific product page.

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Migraine Headache Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Migraine is more than a headache; it is a complex and debilitating neurological disorder affecting over a billion people worldwide. For decades, a lack of predictive preclinical models has hampered therapeutic innovation, leaving a significant unmet medical need. Traditional models often fail to recapitulate the intricate cellular and molecular events underlying migraine, such as neuronal hyperexcitability, neuropeptide release, and neuroinflammation.

At Creative Biolabs, we've engineered a focused portfolio of migraine-specific cell models to help you dissect these intricate pathways. Move beyond generic cell lines and work with models designed to reflect the molecular drivers of migraine pathophysiology. Contact us with your project details for help finding the right model and to request a quote or consultation.

Alternatively, you can find specific products by consulting our complete Product List.

Our Migraine Model Types

We offer a range of models to suit your specific research question.

Types	Description
Trigeminal Neuronal Models	CGRP Overexpressing TG Neuron Line: The industry standard for studying CGRP release and antagonism. TRPA1-Expressing TG Neuron Line: For investigating the role of environmental irritants and TRP channel sensitization. KCNK18 (TRESK) Knockout TG Neuron Line: A key model for studying genetic links to migraine aura and cortical spreading depression.
Glial & Supporting Cell Models	Immortalized Satellite Glial Cells (SGCs): Essential for studying neuro-glial interactions and the inflammatory response within the ganglion. Dura Mater Fibroblast Line: A critical tool for investigating sterile inflammation in the meninges.
Co-Culture Ready Systems	Our models are validated for compatibility, allowing you to build more complex, physiologically relevant co-culture systems of neurons and glia.

Advantages

Choosing Creative Biolabs models gives your research a distinct edge.

Generate More Predictive Data

By using cells that express relevant migraine targets, your findings on drug efficacy or pathway activation are more likely to translate to in vivo systems.

Get Clearer Results

Eliminate the noise. Our well-defined models provide a clean background for studying specific mechanisms like CGRP release, neuronal sensitization, or inflammatory responses.

Shorten Your Discovery Timeline

Skip the time-consuming and costly process of primary cell isolation or in-house model development. Our validated models let you start your key experiments sooner.

Achieve Batch-to-Batch Consistency

Move away from the inherent variability of primary cultures. Our cell lines provide a stable, reproducible platform for longitudinal studies and high-throughput screening.

Applications

These models are versatile tools for nearly every stage of migraine research and drug discovery.

Applications	Description
Mechanism of Action Studies	Investigate how trigeminal neurons become sensitized. Explore the cross-talk between neurons and satellite glial cells in a controlled environment.
Target Identification & Validation	Use our knockout/overexpression models to confirm whether a specific protein or pathway is critical for nociceptive signaling.
High-Throughput Screening (HTS)	Screen compound libraries to identify novel antagonists of CGRP release or modulators of ion channel activity.
Therapeutic Efficacy Testing	Assess the ability of your lead compounds to reverse capsaicin-induced CGRP release or other cellular-level migraine phenotypes.
Neuroinflammation Research	Model the inflammatory cascade within the trigeminal ganglion and dura mater.

A picture that presents the involvement of the CGRP and PACAP in migraine and depression. (Viudez-Martínez, et al., 2024) (OA Literature)

Fig.1 The involvement of the CGRP and PACAP in migraine and depression.¹

FAQs

What makes your cell models specific for migraine research?
Our models are primarily derived from trigeminal ganglion neurons, the key cell type that initiates migraine pain signaling. We've optimized them to express high levels of CGRP and other relevant targets and validated their functional response to stimuli known to trigger migraine-like events, making them highly specific and relevant.
Can we use these models to test our specific class of compounds, like antibodies or biologics?
Absolutely. The models are versatile and have been successfully used to test small molecules, peptides, and monoclonal antibodies. The best approach depends on your target. We encourage you to schedule a brief consultation with our scientists to discuss your compound and design the most effective experiment.
Can I use these models for CGRP release assays?
Absolutely. Our CGRP Overexpressing TG Neuron Line is specifically optimized for this application, providing a robust and reproducible signal window.
Can you create a custom model for a target you don't list?
Yes, we offer custom cell line engineering services. Contact our scientific team to discuss your project requirements.
Are the cells human or rodent-derived?
We offer models from both human and rodent (rat, mouse) origins to support a wide range of research and translational studies. Please check the specific product page.

Creative Biolabs provides the validated tools and expert support necessary to navigate the complexities of migraine drug discovery. Our high-quality Migraine Headache Cell Model Products deliver the consistent, physiologically relevant data you need to advance your project with confidence. Contact our team of scientists to discuss your research goals, and let's work together to find the perfect model system that integrates seamlessly into your workflow.