Why use these human cell models instead of animal models?

Because they are human, our models better reflect human-specific genetics and disease traits. This helps close the "translational gap," where animal study results often fail to carry over to people, giving your research more relevant insights.

Can you make a cell model for my specific mutation?

Yes. Our custom services can add a specific mutation to a healthy cell line using CRISPR-Cas9. Alternatively, we can help you develop a new line directly from your patient samples to match their unique genetic background.

Can I use these cells for large-scale drug testing?

Yes. Our models are produced with high consistency from one batch to the next. This reliability, combined with our ability to supply them at scale, makes them an ideal choice for automated High-Throughput Screening (HTS).

Can I use these models to study inflammation?

Definitely. Our portfolio includes iPSC-derived microglia and astrocytes. They are ideal tools for investigating inflammatory signals, analyzing what the cells release, and testing the effectiveness of new anti-inflammatory compounds.

Can these models help me find new biomarkers?

Yes, they are perfectly suited for this. You can analyze what our cell models release into their culture media to discover and validate new biomarkers. Our co-culture models are especially powerful for this, as they show how different cell types interact.

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Cluster Headache Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Unraveling the complexities of cluster headache (CH), one of the most agonizing conditions known, presents a formidable challenge. Progress toward new therapies has been slow, largely because researchers have lacked reliable laboratory models that accurately reflect human physiology.

To solve this problem, we provide specialized cell models made specifically for cluster headache research. Our ready-to-use models give you a reliable, human-based system, helping you move past the limitations of animal studies. They allow you to understand the disease with more clarity, test new drugs with greater accuracy, and ultimately, speed up your work. Talk to our scientific team to discuss your project and get a quote.

For a complete listing of all specific products, please see our comprehensive Product List.

Available Product Types

We offer a focused selection of models to meet your specific research needs.

Types	Description
Cryopreserved Human Trigeminal Ganglion (TG) Neurons	These are the primary sensory neurons involved in the pain of cluster headache. Provided at high purity, they serve as the gold standard for investigating neuronal hyperexcitability, ion channel activity, and the direct effects of new drug compounds.
Human Dural Fibroblasts	These cells are key players in the cranial dura, a tissue strongly implicated in headache mechanisms. They are an essential tool for studying neurovascular inflammation and the release of inflammatory molecules like CGRP and cytokines.
Patient-Derived iPSC Models	For research focused on the genetic roots of the disease, we can provide neurons and other cells derived from iPSCs of consented cluster headache patients. This offers a powerful window into how a specific patient's genetic background contributes to the condition.

Advantages

We provide the reliable tools and expert support you need to overcome challenges and achieve your research goals.

Shorten Your Project's Timeline Significantly

Instead of investing months in creating and validating cellular models from scratch, you can begin your critical experiments almost immediately. Our fully prepared and validated cells allow you to bypass this lengthy development phase entirely.

Generate Results You Can Trust

We implement exhaustive quality control measures and provide comprehensive characterization for every lot. This dedication to quality ensures consistent cell performance, leading to highly reproducible data and dependable conclusions for your work.

Work with a Highly Relevant Disease Model

By utilizing a human cellular framework, you can investigate Cluster Headache in a system that more closely mirrors human biology. This provides a significant advantage over traditional animal models, offering insights that are more likely to be relevant to human patients.

Gain Deeper Mechanistic Insights

The specificity engineered into our models allows for a precise and detailed investigation of the underlying causes of the disease. You can explore molecular pathways, neuroinflammatory processes, and drug mechanisms with a level of clarity that generic models cannot offer.

Devote Your Resources to Discovery

Leave the complex process of model development and optimization to us. By doing so, you can allocate your team's expertise, time, and budget directly toward your primary research objectives and solving the key questions surrounding cluster headache.

Applications

Our cellular models are designed for versatility and can be employed across numerous areas of investigation in headache research.

Applications	Description
Elucidating Disease Mechanisms	Use our models to dissect the signaling functions of key neuropeptides such as CGRP and PACAP and determine their specific contributions to the trigeminal pain pathway.
Large-Scale Therapeutic Screening	The models are optimized for High-Throughput Screening (HTS) platforms, enabling the rapid evaluation of extensive compound libraries, including both small molecules and biologic drugs, to discover promising new therapeutic candidates.
Validating Novel Drug Targets	Employ the models to verify the functional significance of particular receptors, ion channels, or signaling proteins within the pain pathways of Cluster Headache, confirming their suitability as targets for new drug development.
Studying Neuroinflammatory Processes	Our co-culture systems allow for the detailed examination of the cellular crosstalk between trigeminal neurons and associated glial cells (microglia, astrocytes), providing a powerful tool to unravel inflammatory cascades.
Investigating Disease Progression	Analyze the molecular and cellular transitions that underlie the shift from an episodic to a chronic disease state, helping to identify factors that drive the chronification of Cluster Headache.
Quantitative Analysis of Pain Signaling	The models are fully compatible with advanced analytical methods, including electrophysiology and calcium imaging, for the quantitative measurement of neuronal sensitization and the characterization of hyperexcitable states.

A picture that presents the Main sites of action for CGRP in cluster headache. (Carmine Belin, et al., 2020) (OA Literature)

Fig.1 Main sites of action for CGRP in cluster headache.¹

FAQs

Why use these human cell models instead of animal models?
Because they are human, our models better reflect human-specific genetics and disease traits. This helps close the "translational gap," where animal study results often fail to carry over to people, giving your research more relevant insights.
Can you make a cell model for my specific mutation?
Yes. Our custom services can add a specific mutation to a healthy cell line using CRISPR-Cas9. Alternatively, we can help you develop a new line directly from your patient samples to match their unique genetic background.
Can I use these cells for large-scale drug testing?
Yes. Our models are produced with high consistency from one batch to the next. This reliability, combined with our ability to supply them at scale, makes them an ideal choice for automated High-Throughput Screening (HTS).
Can I use these models to study inflammation?
Definitely. Our portfolio includes iPSC-derived microglia and astrocytes. They are ideal tools for investigating inflammatory signals, analyzing what the cells release, and testing the effectiveness of new anti-inflammatory compounds.
Can these models help me find new biomarkers?
Yes, they are perfectly suited for this. You can analyze what our cell models release into their culture media to discover and validate new biomarkers. Our co-culture models are especially powerful for this, as they show how different cell types interact.

At Creative Biolabs, we provide the reliable tools and expert support to help you succeed in your cluster headache research. From high-quality cell models to full-service screening and mechanistic studies, we are your dedicated partner in the quest for novel therapeutics. Contact us to discuss how we can support your next breakthrough and to receive a detailed quote for your project.