Stroke Cell Model Products
Introduction
Globally, stroke is a primary cause of mortality and lasting disability, posing a significant hurdle for both the medical and scientific fields. The intricate pathophysiology of stroke—encompassing a cascade of events including excitotoxicity, oxidative stress, neuroinflammation, and blood-brain barrier (BBB) disruption—demands sophisticated and clinically relevant research models. Advancing beyond the limitations of traditional systems is paramount for deciphering underlying mechanisms and discovering novel, effective neuroprotective and regenerative therapies.
As your committed research partner, Creative Biolabs spearheads the initiative to solve this challenge. We combine more than two decades of biological expertise with advanced cell engineering to provide the research community with a comprehensive portfolio of rigorously validated, physiologically relevant stroke cell models. Our mission is to empower your drug discovery and translational research programs, aiming to reduce failure rates and accelerate the path from laboratory discovery to clinical success. This commitment extends beyond merely supplying cells; it's about delivering reliable, reproducible biological systems designed to generate the actionable data your program needs to succeed.
For a complete catalog, visit our Product List.
Types
To accommodate a broad range of research objectives, Creative Biolabs supplies a diverse selection of stroke models.
| Types | Description |
|---|---|
| Ischemic Neuronal Models | Primary cortical or hippocampal neurons subjected to OGD/R. The gold standard for assessing neuroprotection. |
| Astrocyte Stroke Models | Study the role of astrocytes in glutamate homeostasis, glial scarring, and bystander cell death post-ischemia. |
| Microglial Stroke Models | Investigate neuroinflammatory activation, phagocytosis, and cytokine release in the context of ischemic injury. |
| Brain Endothelial (BBB) Models | Mimic stroke-induced disruption of the blood-brain barrier, ideal for studying vascular permeability and leukocyte extravasation. |
| Advanced Co-Culture Models | Combine neurons, astrocytes, and/or microglia to create a more complex in vitro environment that better reflects the neurovascular unit. |
| Custom Model Development | We partner with you to create bespoke stroke models tailored to your specific cell type, genetic background, or experimental endpoint. |
Advantages
Collaborating with Creative Biolabs offers your research programs a clear and significant advantage.
Accelerate Your Timeline
Bypass the lengthy and resource-intensive process of in-house model development. Our ready-to-use solutions allow you to proceed directly to screening and analysis.
Ensure Data Reproducibility
Our stringent quality control and standardized manufacturing processes minimize experimental variability, leading to more reliable and publishable data.
Achieve Clinically Relevant Insights
By simulating the core mechanisms of stroke injury, our models provide a more predictive understanding of compound efficacy and toxicity than standard cell culture.
Reduce Reliance on Animal Models
Use our high-fidelity in vitro systems for initial screening and lead optimization, refining hypotheses and reducing the number of animals required in later preclinical stages, in line with the 3Rs (Replacement, Reduction, Refinement).
Gain Unambiguous Results
High-purity cell populations reduce confounding data from off-target cell types, enabling clearer interpretation of molecular and cellular pathways.
Applications
Our advanced stroke cell models provide a versatile platform to drive discovery across multiple stages of the therapeutic development pipeline. Empower your research with models designed for these critical applications:
| Applications | Description |
|---|---|
| Screening and Profiling of Neuroprotective Agents | Efficiently evaluate entire compound libraries to identify novel "hit" compounds. Perform detailed dose-response analyses to profile the potency and efficacy of lead candidates in preventing ischemic cell death and promoting survival. |
| Elucidation of Ischemic Injury and Repair Pathways | Move beyond simple viability assays to dissect the core molecular machinery of stroke. Investigate the dynamics of excitotoxicity, oxidative stress, mitochondrial dysfunction, and apoptosis, and map how your therapeutic target modulates these critical pathways. |
| Modeling Blood-Brain Barrier Disruption and Integrity | Utilize our specialized endothelial and co-culture models to investigate ischemia-induced damage to the blood-brain barrier. Assess changes in tight junction protein expression, vascular permeability, and the potential for therapeutics to restore barrier function. |
| Investigating the Glial and Neuroinflammatory Response | Characterize the complex, dual role of astrocytes and microglia following an ischemic event. Our models allow you to study glial activation, cytokine/chemokine release, and phagocytic activity, providing a platform to test novel anti-inflammatory or pro-recovery agents. |
| Validation of Pharmacodynamic and Predictive Biomarkers | Use conditioned media or cell lysates from our controlled in vitro system to discover and validate biomarkers. Identify markers that correlate with injury severity (prognostic) or confirm that a drug is engaging its target effectively (pharmacodynamic). |
Fig.1 A summary of the pathophysiology involved in ischemic stroke.1
FAQs
-
Can the injury parameters be customized for my specific research?
Absolutely. We can tailor the duration of oxygen-glucose deprivation and reoxygenation to model different severities of ischemic stroke. We work with you during the project design phase to define the optimal conditions for your research question. -
Can I test biologics or large molecules in these models?
Yes, our models are suitable for testing a wide range of therapeutic modalities, including small molecules, peptides, antibodies, and other biologics. Our neurovascular unit model is particularly well-suited for assessing the transport and efficacy of large molecules. -
How do I know which cell model is right for my project?
Our team of expert scientists is here to help. During a complimentary consultation, we will discuss your research goals and recommend the model system—be it a simple monoculture or a complex co-culture—that will provide the most relevant and actionable data. -
Can you create a model with a specific genetic modification (e.g., knockout)?
Yes, our custom services team can develop stroke models using cells with specific genetic knockouts, knock-ins, or knockdown modifications. -
Do you offer bulk or discounts?
Yes, we offer flexible pricing structures tailored to the scope and scale of your project, including significant advantages for bulk orders. Please contact our sales team for a personalized quote.
Stop letting model development be the bottleneck in your pipeline. Creative Biolabs empowers researchers to ask bigger questions and get answers faster. By providing robust, clinically relevant, and ready-to-use stroke cell models, we handle the complex biology so you can focus on what matters most: discovering the next generation of neurotherapeutics. Contact our team today for a confidential discussion about your project needs or to request a detailed quote for our products and services.
Related Product Sections
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Reference
- Maida, Carlo Domenico, et al. "Molecular pathogenesis of ischemic and hemorrhagic strokes: background and therapeutic approaches." International journal of molecular sciences 25.12 (2024): 6297. DOI: 10.3390/ijms25126297. Use under Open Access license CC BY 4.0, without modification.