Transverse Myelitis Cell Model Products
Introduction
Developing effective therapies for Transverse Myelitis (TM), a complex inflammatory disorder of the spinal cord, presents significant hurdles for researchers. The disease's intricate pathology damages myelin and leads to debilitating symptoms, yet its diverse causes make it a challenging target for drug discovery.
At Creative Biolabs, we empower you to overcome these challenges. As a leading Discovery Partner, we specialize in high-fidelity in vitro cell models that provide a human-relevant platform to unravel the complexities of TM. Our mission is to provide the sophisticated tools you need to dissect disease mechanisms, identify novel targets, and accelerate your path from discovery to clinical application.
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Types
We provide several configurations to meet diverse research needs, from foundational systems to complex co-cultures that more completely simulate the neuroinflammatory environment of the spinal cord.
| Types | Description |
|---|---|
| Neuron-Oligodendrocyte Basal Model | This foundational co-culture features iPSC-derived neurons and oligodendrocytes. It is specifically designed to isolate and assess the direct impact of therapeutic compounds on the processes of demyelination and remyelination, free from the influence of other glial cell types. |
| Astrocyte-Enriched Neuroinflammatory Model | By incorporating astrocytes, this model provides deeper insight into glial scarring and the bystander effects common in TM pathology. It is ideal for investigating how compounds modulate astrocytic activity and its subsequent impact on neuronal survival and myelin integrity. |
| Microglia-Integrated Immune Model | Our most comprehensive model includes microglia to fully simulate the innate immune response within the central nervous system. This system is essential for studying microglial activation, phagocytosis of myelin debris, and the complex inflammatory cytokine cascade during a TM-like event. |
| Custom Genetically-Modified Models | To support targeted research, we develop bespoke models using cells with specific genetic modifications, such as CRISPR-Cas9 knockouts or reporter gene insertions. This service allows for precise validation of novel drug targets and deep mechanistic investigation of specific genetic pathways. |
Advantages
Our platform is engineered to deliver distinct benefits that accelerate and de-risk your research programs. We focus on providing data that is not only robust but also highly relevant to human disease.
High Physiological Relevance
Our models use exclusively human iPSC-derived cells. This eliminates species-specific artifacts and more accurately predicts potential clinical responses to your compounds compared to conventional animal models.
Exceptional Reproducibility and Scalability
Standardized protocols and stringent quality control ensure high consistency between experiments. The platform is fully scalable, making it ideal for screening multiple compounds or dosage points with reliable results.
Clear Mechanistic Insight
The controlled in vitro environment enables the precise study of specific molecular pathways and cell interactions, providing clear mechanistic data that is often difficult to obtain from complex in vivo systems.
Accelerated Research Timelines
Generate actionable data in weeks, not months. Our efficient platform significantly shortens the timeline for initial efficacy and mechanism-of-action studies, helping you reach critical milestones faster.
Applications
Our Transverse Myelitis models provide a versatile platform to address a wide range of critical research questions, from initial discovery and screening to in-depth mechanistic studies that support clinical translation.
| Applications | Description |
|---|---|
| Therapeutic Efficacy Screening | Systematically evaluate compound libraries in a dose-response manner to identify lead candidates. Our models provide quantitative readouts for neuroprotection, anti-inflammatory activity, and remyelination promotion, enabling efficient and predictive primary screening campaigns before committing to animal studies. |
| Mechanism of Action (MoA) Elucidation | Move beyond what a compound does to understand how it works. The model allows for detailed investigation of signaling pathways, gene expression changes, and specific cellular responses following treatment, providing crucial data for your IND submission package. |
| Biomarker Discovery and Validation | Analyze culture supernatants and cell lysates to identify novel biomarkers. You can correlate levels of specific cytokines, neurofilaments, or other proteins with the disease state or therapeutic response, discovering markers that could translate to clinical use for diagnosis or stratification. |
| Fundamental Pathobiology Research | Investigate the core biological processes that drive Transverse Myelitis. This platform is a powerful tool for discovery research, enabling detailed study of cell-cell communication, inflammatory triggers, and the molecular cascade that leads from inflammation to demyelination and axonal damage. |
Fig.1 Schematic representation of myelitis lesion location and gadolinium enhancement patterns on spinal cord MRI in AQP4-IgG-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), MOG-IgG associated-disease (MOGAD), and multiple sclerosis (MS). 1
FAQs
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Are these cells suitable for genetic modification (e.g., CRISPR/Cas9)?
Yes, our iPSC-derived cells are amenable to standard genetic engineering techniques, allowing you to create custom disease models. -
Can the model be customized to investigate a specific gene or pathway?
Absolutely. We can partner with you to develop customized models, such as incorporating cells with specific genetic modifications (e.g., knockouts or overexpression) to help you explore your pathway of interest. We encourage you to contact us to discuss your specific requirements. -
How do I place an order?
You can request a quote directly from our website or contact our sales team via email or phone to discuss your needs and place an order.
Transverse Myelitis is a complex disease that demands innovative research approaches. The limitations of traditional models have created a bottleneck in the drug development pipeline. Creative Biolabs' advanced in vitro cell model products offer a powerful solution to overcome these challenges, providing a more human-relevant and predictive platform for your research. By partnering with us, you gain access to the tools and expertise needed to dissect disease mechanisms, identify novel therapeutic targets, and ultimately, accelerate the development of life-changing therapies for patients with Transverse Myelitis.
Contact us today to learn how Creative Biolabs' Transverse Myelitis Cell Model Products can empower your research and lead the way to a future free from the burden of this devastating disease.
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Reference
- Fadda, Giulia, et al. "Myelitis features and outcomes in CNS demyelinating disorders: comparison between multiple sclerosis, MOGAD, and AQP4-IgG-positive NMOSD." Frontiers in Neurology 13 (2022): 1011579. DOI: 10.3389/fneur.2022.1011579. Use under Open Access license CC BY 4.0, without modification.