Can these cell models be customized for our specific research target?

Absolutely. Customization is one of our core strengths. We can incorporate genetic modifications, such as CRISPR-based knockouts or knock-ins, to study specific genes or pathways relevant to your research. Let's schedule a call to explore the customization possibilities for your target.

What information do I need to provide to get a quote?

To provide an accurate quote, we typically need to know your research objective, the specific model you're interested in, the assays you require, and the number of compounds you plan to screen, if applicable. The best way to start is by filling out our inquiry form or scheduling a brief consultation with our specialists.

Are your models compatible with high-throughput screening (HTS) platforms and workflows?

Yes, our iPSC-derived models in particular are manufactured at a scale and consistency suitable for HTS applications in 96-well or 384-well formats.

Can I use these cells for patch-clamp electrophysiology?

Absolutely. Our human iPSC-derived neurons and primary rodent neurons are well-suited for manual and automated patch-clamp analysis.

What is the recommended cell seeding density?

The optimal seeding density depends on your application (e.g., ICC vs. biochemical assay). A detailed protocol with recommended densities is provided with every order.

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Trigeminal Neuralgia Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Trigeminal Neuralgia (TN) is an excruciating neuropathic pain condition, often described as one of the most severe pains known to medicine. The paroxysmal, electric shock-like sensations in the facial area present a profound clinical challenge and a significant unmet medical need. For researchers in the pharmaceutical and biotechnology sectors, developing effective, non-addictive therapeutics is a top priority. However, progress has been hampered by a critical bottleneck: the lack of physiologically relevant, human-based preclinical models that can accurately recapitulate the pathophysiology of TN.

At Creative Biolabs, we provide researchers with a suite of highly characterized, ready-to-use human cell models specifically engineered and validated for Trigeminal Neuralgia research. By moving away from animal models and towards human-centric systems, your research can gain unprecedented clinical relevance, accelerating your drug discovery pipeline and increasing the probability of success. Contact our scientific team to discuss your project needs and get a quote.

Alternatively, you can find specific products by consulting our complete Product List.

Types

We provide specialized, highly characterized cell models essential for dissecting the pathology of a wide range of neuro-autoimmune disorders:

Types	Description
Human iPSC-Derived Trigeminal Neurons	Highly pure sensory neurons differentiated from human induced pluripotent stem cells. Available from healthy donors or diagnosed TN patients.
Primary Rodent Trigeminal Neurons	Isolated from the trigeminal ganglia of rats or mice. A well-established model system for neuropathic pain.
Neuron & Schwann Cell Co-Culture System	A more complete model featuring iPSC-derived trigeminal neurons cultured with primary Schwann cells to study neuro-glial interactions and myelination.

Advantages

By integrating Creative Biolabs models into your workflow, you gain significant advantages over developing models in-house or using less specialized tools.

Accelerate Your Research Timeline

Skip the time-consuming and resource-intensive process of sourcing tissue, isolating primary cells, and validating new lines. Our ready-to-use models allow you to start your critical experiments immediately.

Achieve Reliable, Reproducible Results

Our industry-leading quality control and manufacturing consistency mean you can trust your data, whether for a single experiment or a long-term research program.

Increase Translational Confidence

Work with models that better recapitulate human TN pathology. Our iPSC-derived neurons and co-culture systems provide a more accurate reflection of the in vivo environment, increasing the likelihood that your findings will translate.

Focus on Your Core Discovery Work

Let us handle the complex cell model development so you can concentrate on what you do best: investigating disease mechanisms, screening compounds, and publishing your next breakthrough.

Benefit From Our Expertise

Our support doesn't end with the sale. Our team of neurobiologists is available to help you select the right model and optimize your experimental setup.

Applications

Our TN cell models are versatile tools suitable for a wide range of research applications:

Applications	Description
Drug Discovery	Screen small molecules, biologics, or peptides for analgesic efficacy.
Mechanism of Action Studies	Pinpoint how your lead compounds modulate neuronal excitability or protect against demyelination.
Disease Modeling	Investigate the fundamental genetic and cellular drivers of trigeminal neuralgia.
Neurotoxicity Assessment	Evaluate the potential neurotoxic side effects of drug candidates early in development.

A picture that presents the Peripheral mechanisms of trigeminal neuropathic pain. (Bista, et al., 2019) (OA Literature)

Fig.1 Peripheral mechanisms of trigeminal neuropathic pain.¹

FAQs

Can these cell models be customized for our specific research target?
Absolutely. Customization is one of our core strengths. We can incorporate genetic modifications, such as CRISPR-based knockouts or knock-ins, to study specific genes or pathways relevant to your research. Let's schedule a call to explore the customization possibilities for your target.
What information do I need to provide to get a quote?
To provide an accurate quote, we typically need to know your research objective, the specific model you're interested in, the assays you require, and the number of compounds you plan to screen, if applicable. The best way to start is by filling out our inquiry form or scheduling a brief consultation with our specialists.
Are your models compatible with high-throughput screening (HTS) platforms and workflows?
Yes, our iPSC-derived models in particular are manufactured at a scale and consistency suitable for HTS applications in 96-well or 384-well formats.
Can I use these cells for patch-clamp electrophysiology?
Absolutely. Our human iPSC-derived neurons and primary rodent neurons are well-suited for manual and automated patch-clamp analysis.
What is the recommended cell seeding density?
The optimal seeding density depends on your application (e.g., ICC vs. biochemical assay). A detailed protocol with recommended densities is provided with every order.

At Creative Biolabs, we are a committed ally in accelerating the study of trigeminal neuralgia. Our combination of validated cell models, expert-led services, and a truly collaborative mindset equips you to tackle critical obstacles, speed up your development timeline, and deliver new treatments to patients with greater efficiency. Contact our team of specialists to learn more, have your questions answered, and collaborate on designing a study that is tailored to your exact project objectives and requirements.