Parkinson's Disease (PD) Cell Model Products
Introduction
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized primarily by the loss of dopaminergic neurons in the substantia nigra and the accumulation of aggregated α-synuclein in Lewy bodies. Unraveling the complex molecular mechanisms underlying PD and developing effective therapeutic interventions remains a significant challenge. Robust and physiologically relevant cellular models are indispensable tools for dissecting disease pathways, identifying novel drug targets, and evaluating candidate therapies. At Creative Biolabs, we leverage cutting-edge science to provide a comprehensive suite of meticulously characterized Parkinson's Disease cell models. Our models are designed to empower your research, accelerate drug discovery, and pave the way for novel therapeutic interventions. To advance your Parkinson's Disease research, contact our specialists for a personalized consultation and quotation.
Alternatively, specific offerings can be found by directly consulting our comprehensive Product List.
Types of PD Cell Models
| Types | Description |
|---|---|
| Immortalized Human Cell Lines (e.g., H4, HEK293) | These are foundational tools, often genetically modified to overexpress wild-type or mutant forms of PD-related proteins like alpha-synuclein (SNCA), LRRK2, or Parkin. Their ease of culture and transfection make them ideal for initial mechanistic studies and high-throughput screening. |
| Differentiated Neuronal Cell Lines (e.g., differentiated PC12, LUHMES) | These lines can be induced to adopt more mature neuronal phenotypes, including dopaminergic characteristics (expression of tyrosine hydroxylase, DAT). LUHMES cells, for example, are human mesencephalic-derived and can form a highly homogenous population of post-mitotic dopaminergic neurons, excellent for studying neurotoxicity and developmental aspects. |
| Primary Neuronal Cultures (Typically Rodent-derived) | While offering higher physiological relevance due to their origin from brain tissue, these cultures are often heterogeneous, more challenging to maintain and transfect, and raise ethical considerations. They have been valuable for studying fundamental neuronal responses to PD-related insults. |
| Induced Pluripotent Stem Cell (iPSC)-derived Models | A transformative technology, iPSCs can be generated from PD patients (carrying sporadic or familial mutations like SNCA, LRRK2, GBA1, PINK1, PARK2) or healthy individuals and then differentiated into specific neuronal types, predominantly midbrain dopaminergic neurons. This allows for patient-specific disease modeling in a human genetic context. |
| Genetically Engineered Models | This category encompasses any of the above cell types that have been precisely modified using techniques like CRISPR/Cas9 to introduce specific PD-relevant mutations, knockouts, knock-ins, or reporter gene insertions (e.g., for tracking alpha-synuclein aggregation). |
Key Features and Advantages of Creative Biolabs' Parkinson's Disease (PD) Cell Models
High Clinical Relevance
Our models, especially iPSC-derived and human neuronal lines, closely mimic human PD pathology, offering more translatable results.
Reproducibility and Reliability
Standardized protocols and rigorous quality control ensure consistent performance and dependable data.
Tailored Solutions
We offer a wide range of models and can assist in selecting or developing custom models to meet your specific research objectives.
Focus on Key Pathogenic Pathways
Models designed to investigate specific mechanisms like mitochondrial dysfunction, oxidative stress, impaired protein clearance (UPS and autophagy), and α-synuclein toxicity.
Accelerated Research
Ready-to-use, well-characterized models save you valuable time and resources in model development.
Expert Support
Our team of neuroscientists is available to provide technical assistance and scientific consultation.
Cost-Effective
Efficiently designed models provide a high return on investment for your research budget.
Applications of Our PD Cell Models
Our PD cell models are versatile tools for a wide range of research applications:
| Applications | Description |
|---|---|
| Target Identification and Validation | Uncover novel molecular targets involved in PD pathogenesis. |
| Drug Discovery and Development | Screen compound libraries for neuroprotective or disease-modifying agents. |
| Mechanism of Action Studies | Elucidate how candidate drugs exert their therapeutic effects. |
| Biomarker Discovery | Identify cellular biomarkers indicative of disease progression or drug response. |
| Neurotoxicity Testing | Assess the potential of environmental factors or chemicals to contribute to PD pathology. |
| Investigating Pathogenic Pathways | Delve into oxidative stress, mitochondrial dysfunction, protein misfolding and aggregation, impaired proteostasis (UPS, autophagy), neuroinflammation, and synaptic dysfunction. |
Fig.1 Schematic representation of the interactions between glial cells and immune cells in PD.1
FAQs
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Can you develop custom PD cell models?
Yes, Creative Biolabs specializes in custom model development. Please contact us with your specific requirements. -
How do your neurotoxin models mimic PD?
Neurotoxins like MPP+ or 6-OHDA selectively damage dopaminergic neurons and induce oxidative stress or mitochondrial dysfunction, recapitulating key pathological features of PD. -
Can these models be used to study the spread of α-synuclein pathology?
Yes, we offer models and systems, including co-culture or microfluidic setups, suitable for investigating cell-to-cell transmission of α-synuclein. -
Can I publish research using Creative Biolabs' cell models?
Absolutely. Our models are designed for research and publication purposes. We appreciate appropriate acknowledgment. -
Who can I contact for technical support or more information?
Our dedicated team of scientific experts is available to answer your questions. Please visit our contact page or email us directly.
Creative Biolabs is dedicated to providing the scientific community with superior cellular models and services to accelerate the understanding and treatment of Parkinson's disease. Our commitment to innovation, quality, and customer satisfaction makes us the ideal partner for your research endeavors. Contact us to discuss your Parkinson's disease cell model requirements and discover how Creative Biolabs can help you achieve your research milestones.
Related Product Sections
For more categories of Neurodegenerative Disease related Research Tools, please visit the following link:
Reference
- MacMahon Copas, Adina N., et al. "The pathogenesis of Parkinson's disease: a complex interplay between astrocytes, microglia, and T lymphocytes?" Frontiers in neurology 12 (2021): 666737. DOI: 10.3389/fneur.2021.666737. Use under Open Access license CC BY 4.0, without modification.