Does your portfolio include microglia for the development of complex, multicellular co-culture systems?

Yes. Our portfolio includes iPSC-derived microglia, which can be combined with our astrocyte and neuronal models. This enables the creation of a more sophisticated in vitro system designed to investigate the contributions of neuroinflammation to epilepsy.

What is the process for requesting a quote for a large-volume order or a custom project?

Requesting a quote is straightforward. The best way is to use the "Request a Quote" form on our website or contact our scientific account managers directly. To ensure we provide the most accurate and competitive proposal, please include the specific model(s) of interest, the required quantity or scale of your project, and a brief overview of your research application. This allows us to tailor a solution that precisely fits your needs.

Our research focuses on a gene not listed in your catalog. Can Creative Biolabs create a custom model for us?

Yes, this is one of our core strengths. Our custom model development service is a collaborative partnership designed to build the exact tools you need. Our expert team can manage the entire workflow, from initial project design and consultation to CRISPR/Cas9 gene editing (including knock-ins, knock-outs, and specific point mutations) and full functional validation. Contact us to discuss your target and project goals.

How can I find out if you have a model for the specific genetic epilepsy we study?

We recommend starting by browsing our expanding catalog of genetically-engineered disease models, which includes validated lines for prevalent channelopathies like SCN1A and KCNQ2. If you do not see your gene of interest, please don't hesitate to contact us. Our team can either inform you of newly available models or discuss initiating a custom development project to create a bespoke iPSC-derived model tailored precisely to your research.

My lab has limited experience with iPSC culture. Are your cell models suitable for our team?

Absolutely. Our products are engineered for accessibility and designed to let you focus on your research, not on complex cell culture. All our models are delivered as cryopreserved, "assay-ready" vials with highly detailed, step-by-step protocols that have been optimized for high viability and robust performance. Furthermore, our dedicated Ph.D.-level technical support team is always available to provide guidance and ensure your success from thaw to data.

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Epilepsy & Seizure Cell Model Products

Introduction Types Advantages Applications FAQs Related Product Sections Product List

Introduction

Navigating the complex landscape of epilepsy drug discovery requires moving beyond traditional approaches. As a spectrum of disorders characterized by recurrent seizures, epilepsy's profound heterogeneity—rooted in everything from specific channel mutations to broad synaptic dysregulation—means that effective preclinical models must capture a new level of biological nuance. The demand is for platforms that are not only scalable but also highly predictive and directly translatable to human pathology.

At Creative Biolabs, we thrive on this complexity. For more than 20 years, we have partnered with industry pioneers, recognizing that high-fidelity models are the catalyst for therapeutic breakthroughs. Our Epilepsy & Seizure Cell Model portfolio embodies this principle. These are not mere reagents, but fully validated, assay-ready systems engineered to provide critical insights, de-risk your pipeline, and shorten the journey from benchtop to breakthrough.

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Details on all offerings are in the complete Product List.

Available Model Types

We offer a diverse selection of models to meet your specific research needs.

Types	Description
iPSC-Derived Glutamatergic Neurons	Ideal for studying mechanisms of hyperexcitability.
iPSC-Derived GABAergic Neurons	Perfect for investigating inhibitory circuit dysfunction.
Defined Co-Cultures	These are mixed populations of glutamatergic and GABAergic neurons to create more complex, physiologically relevant circuits.
Astrocyte Cultures	For studying the role of glia in neuronal health and seizure modulation.
Genetically-Engineered Disease Models	A catalog of CRISPR-edited lines for monogenic epilepsies like Dravet Syndrome (SCN1A) and developmental epileptic encephalopathies (KCNQ2, CDKL5).
Wild-Type & Isogenic Controls	The essential baseline controls for rigorous, interpretable science.
Custom Model Development	We offer services to create custom genetic models tailored to your specific research target.

Advantages

Partnering with Creative Biolabs provides a distinct competitive edge for your research programs.

Enhanced Physiological Relevance

Utilize human-derived models that overcome species-specific differences, increasing the likelihood of clinical translation.

Unparalleled Reproducibility

Rigorous QC and manufacturing standards ensure minimal lot-to-lot variability, leading to more consistent and reliable experimental outcomes.

Accelerated Timelines

Bypass the time-consuming process of iPSC differentiation and characterization. Our ready-to-use models allow you to move directly to your functional assays.

High-Throughput Scalability

Our models are optimized for multi-well plate formats, making them ideal for large-scale compound screening and neurotoxicity studies.

Expert Technical Support

Gain access to our team of Ph.D.-level scientists to assist with experimental design, data interpretation, and troubleshooting.

Applications

Our models are versatile tools suitable for a wide range of applications across the research and development pipeline.

Applications	Description
Disease Modeling	Investigate the cellular and network pathophysiology of specific genetic epilepsies.
Drug Discovery & Compound Screening	Perform high-throughput screening (HTS) to identify novel anti-epileptic compounds that modulate neuronal excitability.
Mechanism of Action (MoA) Studies	Elucidate how lead compounds exert their therapeutic effects at the cellular level.
Target Identification & Validation	Use genetic models to confirm the role of specific ion channels or proteins in seizure generation.
Neurotoxicity Assessment	Screen compounds for pro-convulsant liabilities early in the development process.
Personalized Medicine Research	Study patient-specific mutations to explore tailored therapeutic strategies.

A picture that presents the Role of glia and chemokines in the progression of neuroinflammation in epilepsy. (Mohapatra, et al., 2025) (OA Literature)

Fig.1 Role of glia and chemokines in the progression of neuroinflammation in epilepsy.¹

FAQs

Does your portfolio include microglia for the development of complex, multicellular co-culture systems?
Yes. Our portfolio includes iPSC-derived microglia, which can be combined with our astrocyte and neuronal models. This enables the creation of a more sophisticated in vitro system designed to investigate the contributions of neuroinflammation to epilepsy.
What is the process for requesting a quote for a large-volume order or a custom project?
Requesting a quote is straightforward. The best way is to use the "Request a Quote" form on our website or contact our scientific account managers directly. To ensure we provide the most accurate and competitive proposal, please include the specific model(s) of interest, the required quantity or scale of your project, and a brief overview of your research application. This allows us to tailor a solution that precisely fits your needs.
Our research focuses on a gene not listed in your catalog. Can Creative Biolabs create a custom model for us?
Yes, this is one of our core strengths. Our custom model development service is a collaborative partnership designed to build the exact tools you need. Our expert team can manage the entire workflow, from initial project design and consultation to CRISPR/Cas9 gene editing (including knock-ins, knock-outs, and specific point mutations) and full functional validation. Contact us to discuss your target and project goals.
How can I find out if you have a model for the specific genetic epilepsy we study?
We recommend starting by browsing our expanding catalog of genetically-engineered disease models, which includes validated lines for prevalent channelopathies like SCN1A and KCNQ2. If you do not see your gene of interest, please don't hesitate to contact us. Our team can either inform you of newly available models or discuss initiating a custom development project to create a bespoke iPSC-derived model tailored precisely to your research.
My lab has limited experience with iPSC culture. Are your cell models suitable for our team?
Absolutely. Our products are engineered for accessibility and designed to let you focus on your research, not on complex cell culture. All our models are delivered as cryopreserved, "assay-ready" vials with highly detailed, step-by-step protocols that have been optimized for high viability and robust performance. Furthermore, our dedicated Ph.D.-level technical support team is always available to provide guidance and ensure your success from thaw to data.

The challenge of epilepsy demands a higher standard of preclinical tools. At Creative Biolabs, we deliver on that demand. Our Epilepsy & Seizure Cell Model Products are more than just reagents; they are integrated, validated systems designed to generate decision-driving data.

By partnering with us, you gain an extension of your own research team—one with the expertise, technology, and commitment to quality required to navigate the complexities of epilepsy drug discovery. Contact our scientific team today for a confidential consultation. Let's discuss your specific targets, explore our models' capabilities, and design a study that will unlock the full potential of your pipeline.