Sodium-activated Channel Screening Service

Sodium-activated channels gain their name because these channels are triggered by high concentrations of internal sodium. Specialists in the field of ion channel screening, Creative Biolabs provides reliable sodium-activated channel screening services to scientists worldwide to facilitate their study.

Introduction of Sodium-activated Channel

As one of the most known sodium-activated channels, the expression of sodium-activated potassium channels (K_Na channels) is widely distributed in central nervous system. K_Na channels will be activated by the increasing intracellular sodium and triggers potassium transmission via the pore structure. K_Na channels are consisted of six hydrophobic transmembrane domains marked as S1 to S6, with the pore structure located between S5 and S6, and a large C-terminal domain in cytoplasm, containing two predicted regulating domains for potassium conductance. K_Na channels serve important functions in defining the firing characteristics of various neurons, and variations to these channels have a significant impact on how neurons form and function.

Fig.1 The subunit structure of the sodium-activated potassium channel Slack.¹

Sodium-activated Channel Screening Service

Sodium-activated channel, expecially K_Na channels, may play a major role in neural development, neuron plasticity, and intellectual function. For this reason, sodium-activated channels may be good targets for in vitro pharmacological studies of diseases linked to sodium-activated channels. Sodium-activated channel screening allows you to identify potential activators or inhibitors for specific channels that you are interested in.

You have a variety of alternatives for your sodium-activated channel tasks, including the gold-standard electrophysiological strategies. Several technique combinations yield the most reliable findings for your research. Describe the features of several approaches here.

There are still many gaps in the research on sodium-activated channels and two members of K_Na channels are identified, called Slick and Slack. Making a suitable and functional cell model is one of the cornerstones to determining the ligands with expected functions towards your interested sodium-activated channels.

K_Na channels

• K_Na1.1, also known as Slack and SLO2.2, encoded by KCNT1
• K_Na1.2, also known as Slick and SLO2.1, encoded by KCNT2

Features of Our Service

• Exceptional cell model creation skills via experienced team
• Customized assay design and production of assays with quality assurance
• Results from timely reporting are dependable and consistent
• Fast response, affordable screening, and excellent after-sale assistance

Using the best and most suitable research techniques on the sodium-activated channels, Creative Biolabs, which has extensive expertise with ligand-gated ion channel screening research, may expedite your important study development after carefully communicating your goals with you. Please do not hesitate to contact us for further information.

In addition to Sodium-activated Channel Screening, Creative Biolabs also provides you with the following ligand-gated channel screening services

• CNG Channel Screening
• NMDA Receptor Screening
• nAChR Screening
• GABA_AR Screening
• AMPAR Screening
• P2X Receptor Screening
• TRP Channel Screening
• Calcium-activated Channel Screening

Reference

1. Kaczmarek, Leonard K. "Slack, slick, and sodium‐activated potassium channels." International scholarly research notices 2013.1 (2013): 354262. Distributed under Open Access license CC BY 3.0, without modification.

For Research Use Only. Not For Clinical Use.