Transient Receptor Potential (TRP) Channel Screening Service

An ion channel family known as transient receptor potential (TRP) channels is mostly found on the plasma membrane of many different kinds of animal cells, showing relatively non-selective cation permeability. Creative Biolabs, ion channel screening experts, offers trustworthy TRP channel screening services to researchers worldwide to enhance their ligand discovery projects of TRP channels.

Introduction of TRP Channel

Vertebrates have been shown to have TRP channels, which are widely expressed in a variety of cell types and tissues, especially on the plasma membrane. The permeability of these ion channels to cations, such as magnesium, sodium, and calcium, is comparatively nonselective. Six membrane-spanning helices labeled as S1-S6 with intracellular N- and C-termini make up the majority of TRP channels. When fully functioning, the majority of TRP channels form homo- or heterotetramers. The intricate arrangement of p-loops in the tetrameric protein, located in the extracellular domain, forms the ion transmission pore. A wide range of events, including several post-transcriptional processes such as ligand-gating and G-protein receptor coupling, can activate and control mammalian TRP channels. Crucially, a large number of these channels mediate a wide range of experiences, including pressure, vision, warmth, pain, and several types of taste.

Fig.1 Structures representing each TRP channel subfamily.¹

TRP Channel Screening Service

TRP channel mutations have been connected to renal problems, skeletal dysplasia, and neurological diseases and may be a significant factor in cancer. Thus, TRP channels could be useful targets for in vitro pharmacological research of TRP channel-related disease. Finding possible activators or inhibitors for certain TRP channels that you are interested in is made possible via TRP channel screening.

For your TRP channel screening projects, you have a number of options, like non-electrophysiological strategy. The most trustworthy results for your study come from a variety of approach combinations. Here describe the characteristics of different methods.

The length of the extracellular loop connecting the S1 and S2 transmembrane segments separates the nine families in the animal TRP superfamily into two groups. One of the keys to identifying the ligands with predicted functionalities is creating a proper and functioning cell model.

Group 1

• TRPC family, representative subfamily TRPC1
• TRPN family, representative subfamily TRPN/nompC
• TRPS family
• TRPM family, representative subfamily Alpha - TRPM1
• TRPVL family
• TRPV family, representative subfamily TRPV1
• TRPA family, representative subfamily TRPA1

Group 2

• TRPML family, representative subfamily TRPML1
• TRPP family, representative subfamily PKD1-like

Features of Our Service

• Considerable expertise in ion channel screening and building bespoke cell models
• Specific assay creation and a customized assay approach
• Cost-effective, one-stop solution with quality assurance
• Detailed data interpretation and top-notch post-purchase assistance

With a great deal of experience in ligand-gated channel screening research, Creative Biolabs can speed up your crucial research development by using the most proper research methods on the TRP channel after carefully listening to your intentions. For further information, don't be afraid to contact us for more details.

In addition to TRP Channel Screening, Creative Biolabs also provides you with the following ligand-gated channel screening services

• CNG Channel Screening
• NMDA Receptor Screening
• nAChR Screening
• GABA_AR Screening
• AMPAR Screening
• P2X Receptor Screening
• Calcium-activated Channel Screening
• Sodium-activated Channel Screening

Reference

1. Zhang, Miao, et al. "TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases." Signal Transduction and Targeted Therapy 8.1 (2023): 261. Distributed under Open Access license CC BY 4.0. The image was modified by extracting and using Part A-G of the original image.

For Research Use Only. Not For Clinical Use.